Dr. WEN JIANGProfessor
PROFESSIONAL FACULTY RESEARCH
(Cryo-EM, structural biology, biophysics, and computational biology) Structures of viruses, protein complexes, nano-particles; Structure based drug discovery; D evelopment of cryo-EM methods including stablization of protein conformations, affinity grids, TEM alignment, data collection automation, and image processing/3D reconstruction algorithms
Our group is interested in structural biology of viruses, large macromolecular complexes, and membrane proteins. The major tool we use is electron cryo-microscopy (cryo-EM), an emerging technique that has seen dramatic progresses and expansion of the field recently. Our research centers around technique development and application of this method, aiming at higher resolution (2-4 Angstrom), higher throughput imaging and 3-D reconstruction, and broader applicability for new target systems and by novice users. See more detailed descriptions of our research projects on our group page.