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Associate Professor

Associated website(s):

Lab Website , Publications



(Cancer and Molecular Biology) Identifying roles for microRNAs in cancer development and progression and using this knowledge for clinical applications.


Greater than 90% of the human genome is transcribed, yet the functional role for most transcripts is unknown. Many of these unknown transcripts fall into a class of RNAs referred to as non-coding RNAs. The general goal of the Kasinski Lab is to determine the molecular contribution of non-coding RNAs (microRNAs, lncRNA, circRNAs) in normal and disease cells, and to capitalize on this knowledge through developing RNA-based therapeutics. The current projects in the Kasinski lab are subdivided into the following:

Project 1: Ligand-mediated delivery of therapeutically relevant small RNAs

Project 2: Endogenous delivery of RNAs through secreted extracellular vesicles (ie. exosomes)

Project 3: High throughput screening for small molecule inhibitors that alter miRNA biogenesis

Project 4: Identification of miRNAs and protein-coding genes mediating drug resistance

Education and Training

  • 2003-2009 - PhD, Emory University
  • 2009-2013 - Postdoctoral Fellow, Yale University


  • 2018, Purdue University, Department of Biological Sciences’ Team Award
  • 2018, Purdue University, Seed for Success – for obtaining external sponsored award of $1 million or more, NIH-R01CA226259
  • 2018, Purdue University, Seed for Success – for obtaining external sponsored award of $1 million or more, NIH-R01CA205420
  • 2018, American Cancer Society, Research Scholar Awardee, gratefully declined
  • 2017, American Cancer Society, Research Scholar Awardee
  • 2015, Favorite Faculty Nominee, Purdue University
  • 2015, Student Loan Repayment Program, National Institutes of Health, National Cancer Institutes
  • 2013, Pathway to Independence Award, National Institutes of Health, National Cancer Institutes
  • 2013, Benjamin F. Trump Award, Aspen Cancer Conference
  • 2013, Aspen Cancer Fellow
  • 2012, Pilot Grant, Yale Center for Molecular Discovery
  • 2012, Student Loan Repayment Program, National Institutes of Health
  • 2012, Women in Cancer Research Scholar, American Association of Cancer Research
  • 2011, Postdoctoral Fellowship, American Cancer Society
  • 2010, Postdoctoral Fellowship, National Institutes of Health, National Cancer Institute
  • 2008, Graduate Student Research Festival, National Institutes of Health

Relevant Publications

  • Elshafie, N., do Nascimento, N., Lichti, N., Kasinski A.L., Childress, M., Santos, A. ( 2021 ) MicroRNA biomarkers in canine diffuse large B-cell lymphoma. Veterinary Pathology 2021 Jan;58(1):34-41
  • Li,  W., Wang, Y., Liu, R., Kasinski, A.L., Shen, H., Slack, F.J., and Tang, D.G. ( 2021 ) MicroRNA-34a (miR-34a): Potent Tumor Suppressor, Cancer Stem Cell Inhibitor and Potential Anti-Cancer Therapeutic , Frontiers in Cell and Developmental Biology, 9:640587.
  • Abdelaal, A.M., and Kasinski, A.L. ( 2021 ) Ligand-mediated delivery of RNAi-based therapeutics for the treatment of oncological diseases. Nucleic Acids Research Cancer, Jul 2-;3(3):zcabb030
  • Pal, A.S., Bains, M., Agredo, A., Kasinski A.L. ( 2020 ) Identification of microRNAs that promote erlotinib resistance in non-small cell lung cancer Biochemical Pharmacology 2020 Jul 16:114154
  • Li, C., Kasinski A.L. (2020) In vivo cancer-based functional genomics. Trends in Cancer 2020 Dec;6(12):1002-1017
  • Myoung, S., and Kasinski, A.L. ( 2019 ) MicroRNAs in Diseases and Disorders – Emerging Therapeutic Targets. Chapter 14: Strategies for safe and targeted delivery of microRNA therapeutics. Royal Society of Chemistry.  386-415 May 2019
  • Orellana E.A., Li, C., Lisevick, A., and Kasinski, A.L . (2019) Identification and validation of microRNAs that synergize with miR-34a – a basis for combinatorial microRNA therapeutics . Cell Cycle, July 2019,
  • Orellana, E.A., Abdelaal, A.H., Rangasamy, R., Tenneti, S., Myoung, S., Low, P.S., Kasinski, A.L. ( 2019 ) Enhancing microRNA activity through increased endosomal release mediated by nigericin. Molecular Therapy: Nucleic Acids, Vol 16, 505-518
  • Kasinski, A.L. ( 2019 ) Combatting PDAC with two tumor-targeting small RNAs. Oncotarget 2019; 10:5892-5893
  • Orellana, E.A., Kasinski, A.L. ( 2017 ) No vehicle, no problem . Oncotarget. 2017 Oct27;8(57):96470-96471
  • Rangasamy, L., Venkatesh, C., Kanduluru, A.K., Srinivasaro, M., Bandara, A. You, F., Orellana, E.A., Kasinski, A.L. , Low, P.S. (2017) New mechanism for release of endosomal contents: osmotic lysis via nigericin-mediated K + /H + exchange. Under review
  • Pal, A.S., Kasinski, A.L. (2017) Animal models to study microRNA function . Advances in Cancer Research 135:53-118
  • Orellana, E.A., Tenneti, S., Rangasamy, L., Lyle, L.T., Low, P.S., Kasinski, A.L. (2017) FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer . Science Translational Medicine, August 2; 9(401):eaam9327
  • Gilbert-Ross, M., Konen, J., Koo, J., Shupe, J., Robinson, B.S., Wiles 4th, W.G., Huang, C., Martin, W.D., Behera, M., Smith, G.H., Hill, C.E., Rossi, M.R., Sica, G.L., Rupji, M., Chen, Z., Kowalski, J., Kasinski, A.L. , Ramalingam, S.S., Fu, H., Khuri, F.R., Zhou, W., Marcus, A.I. (2017) Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma . JCI Insight, March 9; 2(5):e90487
  • Orellana, E.A., Kasinski, A.L. (2016) Sulforhodamine B (SRB) assay in cell culture to investigate cell proliferation . Bio-Protocol, November 5; 6(21) pii:e1984
  • Orellana, E.A., Kasinski, A.L. (2015) MicroRNAs in cancer: A historical perspective on the path from discovery to therapy . Cancers, July 27; 7(3):1388-1405
  • Kasinski, A.L. , Kelnar, K., Stahlhut, C., Orellana, E., Zhao, J., Shimer, E., Dysart, S., Chen, X., Bader, A.G., Slack, F.J. (2015) A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer . Oncogene, July; 34(27):3547-3555
  • Zeiger, E., Gollapudi, B., Aardema, M.J., Auerbach, S., Boverhof, D., Custer, L., Dedon, P., Honma, M., Ishida, S., Kasinski, A.L. , Kim, J.H., Manjanatha, M.G., Marlowe, J., Pfuhler, S., Pogribny, I., Slikker, W., Stankowski, Jr., L.F., Tanir, J.Y., Tice, R., van Benthem, J., White, P., Witt., K.L, Thybaud, V. (2015) Opportunities to integrate new approaches in genetic toxicology: An ILSI-HESI workshop report . Environmental and Molecular Mutagenesis, April; 56(3):277-285
  • Humphrey, S.E., Kasinski, A.L. (2015) RNA-guided CRISPR-Cas technologies for genome-scale investigation of disease processes . Journal of Hematology & Oncology, April 2; 8:31
  • *Adams, B.D., * Kasinski, A.L. , Slack, F.J. (2014) Aberrant regulation and function of microRNAs in cancer. Current Biology, August 18; 24(16):R762-R776 *co-first author
  • Kasinski, A. , Dong, X., Khuri, F.R., Boss, J., Fu, H. (2014) Transcriptional regulation of YWHAZ, the gene encoding 14-3-3ζ. PLoS One, April 1; 9(4):e93480
  • * Kasinski, A. , *Slack, F.J. (2013) Small RNAs deliver a blow to ovarian cancer . Cancer Discovery, Nov; 3(11):1220-1221 *co-corresponding authors
  • Kasinski, A.L. , Slack, F.J. (2013) Generation of mouse lung epethelial cells. Bio-Protocol, August 5; 3(15):e837
  • Kasinski, A.L., Slack, F.J. (2012) miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma. Cancer Research, Nov 1; 72(21):5576-5587
  • Kasinski, A.L., Slack, F.J. (2012) Arresting the culprit: targeted antagomir delivery to sequester oncogenic miR-221 in HCC. Molecular Therapy – Nucleic Acids, March 20; 1(3):e12
  • Kasinski, A.L., Slack, F.J. (2011) M icroRNAs en route to the clinic: progress in validating and targeting miRNAs for cancer therapy. Nature Reviews Cancer, Nov 24; 11(12):849-864
  • Kim, M., Kasinski, A.L., Slack, F.J. (2011) MicroRNA therapeutics in pre-clinical cancer models. Lancet Oncology, Apr;12(4):319-321
  • Kasinski, A.L., Slack, F.J. (2010) Potential microRNA therapies targeting Ras, NF Κ B and p53 signaling. Current Opinion in Molecular Therapeutics, Apr; 12(2):147-157

Invited and Selected Presentations

  • Harvard Medical School Initiative for RNA Medicine, June 2022
  • RNA-mediated silencing, Barbados, January 2022
  • Decoding microRNA Mysteries in Health and Disease, University of Illinois College of Dentistry, September 2021
  • Purdue Women in Science Program, West Lafayette, IN, November 2020
  • Manchester University, North Manchester IN, September 2020
  • Indo-UK Conference on Current Innovations and Future of Therapeutic Developments, Virtual Conference, June 2020
  • mRNA Untranslated Regions in Gene Regulation, Development, and Disease, Barbados, January 2020
  • Roswell Park Cancer Institute, The University of Buffalo, Developmental Therapeutics Seminar Series, January 2020
  • Mahidol University, Bangkok Thailand, March 2019
  • Keynote Speaker, 19th Annual Fellow’s Colloquium, National Cancer Institute, Bethesda, MA, February 2019
  • 5 th Annual International Conference on Drug Discovery, Development and Lead Optimization, Boston MA, November 2019
  • Purdue Science Student Council, West Lafayette, IN October 2019
  • Purdue Center for Cancer Research, CIS series, West Lafayette IN, February 2019
  • Keynote, Purdue Relay for Life’s Hope Gala, West Lafayette, IN, February 2019
  • Biden Cancer Summit, Purdue 150th Anniversary Celebration, West Lafayette, IN, September 2018
  • Keynote, NSF-Funded Science Outreach, Carnegie Museum, Crawfordsville, IN, April 2018
  • FASEB SRC: Post-transcriptional control of gene expression, Scottsdale AZ, June 2018
  • Midwest Chromatin and Epigenetics Meeting, Purdue University, West Lafayette, IN, June 2018
  • University of Montreal, February 2018
  • 2nd International Aegean Conference on the Long and the Short of Non-Coding RNAs, Heraklion, Crete, Greece, June 9, 2017
  • 22nd Annual Meeting of the RNA Society, Prague, Czech Republic, May 30, 2017
  • American Association for Cancer Research Annual Meeting, Washington, DC, April 1, 2017
  • Keystone Symposia on Molecular and Cellular Biology, Banff, Alberta Canada, February 7, 2017
  • 6th International Symposium on Folate Receptors, Breckenridge, CO, September 19, 2016
  • American Association for Cancer Research Annual Meeting, New Orleans, LA, April 16, 2016
  • Experimental Biology, San Diego, April 5, 2016
  • 3rd Annual Summit on Thoracic Malignancies and Head and Neck Cancer, Puerto Rico, December 10, 2015
  • Keystone Symposia on Molecular and Cellular Biology, Denver, CO, June 7, 2015
  • microRNA as Biomarkers and Diagnostics, Cambridge, MA, March 16, 2015
  • 2nd Annual Lung Cancer Summit, Dallas, TX, December 12, 2014
  • microRNA World Conference, Boston, MA, October 27, 2014
  • Aspen Cancer Conference, Aspen, Co, July 15, 2013
  • NIH Lung SPORE Workshop, National Cancer Institute, Rockville, MD, July 11, 2013
  • Department of Molecular Pathology, MD Anderson Cancer Center, Houston Tx, April 5, 2013
  • Department of Clinical Cancer Prevention, MD Anderson Cancer Center, Houston Tx, March 26, 2013
  • Departments of Hematology and Medical Oncology, and Radiation Oncology, Emory University, Atlanta, Ga, March 13, 2013
  • Department of Biology, Purdue University, West Lafayette, IN, December 12, 2012
  • The 4 th Japanese Association for RNAi International Symposium, Hiroshima, Japan, August 30, 2012
  • Thoracic Oncology Board, Emory University, Atlanta GA, May 1, 2012
  • ILIS Health and Environmental Science Institute, Silver Springs MD, April 24, 2012
  • American Association of Cancer Research Annual Meeting, Chicago, IL, April 2, 2012
  • Eighth Annual microRNA in Human Disease and Development Meeting, Cambridge Healthtech, Cambridge, MA, March 12, 2012

Current Grant Funding

  • R01 NCI - CA205420 "Enhancing miRNA Therapeutics Through Combinatorial Targeting and Vehicle-Free Delivery"
  • R00 NCI - CA178091 "Identification and Therapeutic Application of miRNA Drivers in Lung Cancer"
  • RSG-17-198-01, American Cancer Society "Enhancing microRNA Therapeutics Through Vehicle-Free Delivery"

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