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Associate Professor

Associated website(s):




(Structural biology) Structural cell biology of infection, immunity, and aging.


Our research seeks to understand biological structure and its relationship to function by employing a combination of experimentation (structural biology/biophysics) and computation (computational biology/bioinformatics) to answer questions that neither computation nor experiment can answer alone.  Questions needing this combined approach include elucidating structural information from challenging systems, where we combine multiple biophysical and biochemical tools to build coherent models.   These questions also include the functional consequences of the interactions between and within molecules that are revealed by structural models.  Here we combine sequence information, the generation and testing of mutant and chimeric proteins, and modeling and analysis to understand the true importance of amino acid interactions.

The biological systems that we employ for our studies are drawn from our longstanding interests in (i) the damage that results to macromolecules upon aging and their repair by cellular processes and (ii) the interactions between organisms as they form symbiotic, mutualistic or parasitic relationships.  In both these areas, macromolecular structure intersects with evolutionary strategies to determine the health, reproduction and longevity of organisms and ecosystems.


Ph.D., Yale, 1989

Professional Faculty Research

(Structural biology) Structural cell biology of infection, immunity, and aging.

Other Activities

  • Argonne Labs, Argonne, Illinois, July 10, 2003. Site visit review for the BioCAT beamline as a collaborating investigator.

Faculty Presentations
  • Combining bioinformatics and rapid experimentation in protein structure: multimodel discrimination of protein fold, Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, June 20, 2003.
  • Protein expression and characterization to enable multimodel discrimination of protein and protein complex structures, DOE-sponsored discussion of a Protein Purification and Characterization Facility, Argonne National Labs, February 4, 2004.

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