Alan Friedman Publications

Avramova, L. V., Desai, J., Weaver, S., Friedman, A. M., Bailey-Kellogg, C. 2008. Robotic hierarchical mixing for the production of combinatorial libraries of proteins and small molecules. J Comb Chem. 10: 63-68.

Williamson, T. E., Craig, B. A., Kondrashkina, E., Bailey-Kellogg, C., Friedman, A. M. 2008. Analysis of self-associating proteins by singular value decomposition of solution scattering data. Biophys J. 94: 4906-4923.

Ye, X., Friedman, A. M., Bailey-Kellogg, C. 2007. Hypergraph model of multi-residue interactions in proteins: sequentially-constrained partitioning algorithms for optimization of site-directed protein recombination. J Comput Biol. 14: 777-790.

Saftalov, L., Smith, P. A., Friedman, A. M., Bailey-Kellogg, C. 2006. Site-directed combinatorial construction of chimaeric genes: general method for optimizing assembly of gene fragments. Proteins. 64: 629-642.

Schultz, D. A., Friedman, A. M., White, M. A., Fox, R. O. 2005. The crystal structure of the cis-proline to glycine variant (P114G) of ribonuclease A. Protein Sci. 14: 2862-2870.

Pincas, H., Pingle, M. R., Huang, J., Lao, K., Paty, P. B., Friedman, A. M., Barany, F. 2004. High sensitivity EndoV mutation scanning through real-time ligase proofreading. Nucleic Acids Res. 32: e148.

Potluri, S., Khan, A. A., Kuzminykh, A., Bujnicki, J. M., Friedman, A. M., Bailey-Kellogg, C. 2004. Geometric analysis of cross-linkability for protein fold discrimination. Pac Symp Biocomput. 447-458.

Ye, X., O'Neil, P. K., Foster, A. N., Gajda, M. J., Kosinski, J., Kurowski, M. A., Bujnicki, J. M., Friedman, A. M., Bailey-Kellogg, C. 2004. Probabilistic cross-link analysis and experiment planning for high-throughput elucidation of protein structure. Protein Sci. 13: 3298-3313.

Bennett, E. J., Bjerregaard, J., Knapp, J. E., Chavous, D. A., Friedman, A. M., Royer, W. E., Jr., O'Connor, C. M. 2003. Catalytic implications from the Drosophila protein L-isoaspartyl methyltransferase structure and site-directed mutagenesis. Biochemistry. 42: 12844-12853.

Ng, P. S., Pingle, M. R., Balasundarum, G., Friedman, A., Zu, X., Bergstrom, D. E. 2003. Endcaps for stabilizing short DNA duplexes. Nucleosides Nucleotides Nucleic Acids. 22: 1635-1637.

Zhu, Z., Zhou, J., Friedman, A. M., Xu, S. Y. 2003. Isolation of BsoBI restriction endonuclease variants with altered substrate specificity. J Mol Biol. 330: 359-372.

Smith, C. D., Carson, M., Friedman, A. M., Skinner, M. M., Delucas, L., Chantalat, L., Weise, L., Shirasawa, T., Chattopadhyay, D. 2002. Crystal structure of human L-isoaspartyl-O-methyl-transferase with S-adenosyl homocysteine at 1.6-A resolution and modeling of an isoaspartyl-containing peptide at the active site. Protein Sci. 11: 625-635.

van der Woerd, M. J., Pelletier, J. J., Xu, S., Friedman, A. M. 2001. Restriction enzyme BsoBI-DNA complex: a tunnel for recognition of degenerate DNA sequences and potential histidine catalysis. Structure. 9: 133-144.

Skinner, M. M., Puvathingal, J. M., Walter, R. L., Friedman, A. M. 2000. Crystal structure of protein isoaspartyl methyltransferase: a catalyst for protein repair. Structure. 8: 1189-1201.

Walter, R. L., Ealick, S. E., Friedman, A. M., Blake, R. C., 2nd, Proctor, P., Shoham, M. 1996. Multiple wavelength anomalous diffraction (MAD) crystal structure of rusticyanin: a highly oxidizing cupredoxin with extreme acid stability. J Mol Biol. 263: 730-751.

Friedman, A. M., Fischmann, T. O., Steitz, T. A. 1995. Crystal structure of lac repressor core tetramer and its implications for DNA looping. Science. 268: 1721-1727.

Shamoo, Y., Friedman, A. M., Parsons, M. R., Konigsberg, W. H., Steitz, T. A. 1995. Crystal structure of a replication fork single-stranded DNA binding protein (T4 gp32) complexed to DNA. Nature. 376: 362-366.

Paliwal, V., Friedman, A. M., Ptak, W., Askenase, P. W. 1994. Monoclonal, antigen-specific, T cell contrasuppressor factor expresses determinants of TCR alpha-chain (not necessarily TCR beta-chain), having a molecular mass of about 40 kDa. J Immunol. 152: 2811-2820.

Ptak, W., Friedman, A. M., Flood, P. M. 1994. Generation of anti-hapten T cell cytotoxicity in vivo. Relationship to contact sensitivity and the role of contrasuppression. Arch Immunol Ther Exp (Warsz). 42: 185-192.

Friedman, A. M., Ptak, W., Brewer, E., Green, D. R., Reuter, P. A., Flood, P. M. 1990. Generation of a T-cell hybridoma producing a contrasuppressor factor for contact sensitivity. Immunology. 71: 282-289.

Friedman, A. M., Ptak, W., Freedman, J., Green, D. R., Flood, P. M. 1989. Prevention of tumor growth and enhancement of cell-mediated immunity by an antigen-specific contrasuppressor factor from a T cell hybridoma. Prog Clin Biol Res. 288: 281-288.

Green, D. R., Friedman, A., Ptak, W., McGhee, J., Flood, P. M. 1989. Contrasuppression, tolerance, and tumor immunity. Prog Clin Biol Res. 288: 245-258.

Flood, P. M., Friedman, A., Freedman, J., Horvat, B., Reuter, P., Ptak, W. 1988. The role of contrasuppression in tumor regression. Immunol Res. 7: 12-22.

Ptak, W., Friedman, A., Bereta, M., Marcinkiewicz, J., Horvat, B., Reuter, P., Green, D. R., Flood, P. M. 1988. The role of contrasuppressor T cells in the adoptive transfer of contact sensitivity responses to picryl chloride. Immunol Res. 7: 1-11.

Flood, P. M., Friedman, A., Horvat, B., Reuter, P., Rodriquez, A., Ptak, W. 1987. Contrasuppression and tumor rejection. Immunol Lett. 16: 297-303.

Rossmann, M. D., Friedman, A. C., Radecki, P. D., Caroline, D. F. 1987. MR imaging of gallbladder carcinoma. AJR Am J Roentgenol. 148: 143-144.

Rosenow, M. K., Zucchini, G. L., Bridwell, P. M., Stuart, F. P., Friedman, A. M. 1983. Properties of liposomes containing 212Pb. Int J Nucl Med Biol. 10: 189-197.

Friedman, A. M., Huang, C. C., Kulmala, H. A., Dinerstein, R., Navone, J., Brunsden, B., Gawlas, D., Cooper, M. 1982. The use of radiobrominated p-bromospiroperidol for gamma-ray imaging of dopamine receptors. Int J Nucl Med Biol. 9: 57-61.

Friedman, A. M., Long, S. R., Brown, S. E., Buikema, W. J., Ausubel, F. M. 1982. Construction of a broad host range cosmid cloning vector and its use in the genetic analysis of Rhizobium mutants. Gene. 18: 289-296.

Kaplan, E., Gergans, G. A., Milo, T., Friedman, A. M., Sharp, J. T. 1982. Dynamic imaging of the respiratory cycle with 81mKr. Chest. 81: 312-317.

Zucchini, G. L., Friedman, A. M. 1982. Isotopic generator for 212Pb and 212Bi. Int J Nucl Med Biol. 9: 83-84.

Kaplan, E., Mayron, L. W., Gergans, G. A., Shponka, S., Barnes, W. E., Friedman, A. M., Gindler, J. E., Fishman, H., Sharp, T. 1981. Pulmonary function and 81mKr scans in obstructive pulmonary disease. Int J Nucl Med Biol. 8: 39-51.

Kulmala, H. K., Huang, C. C., Dinerstein, R. J., Friedman, A. M. 1981. Specific in vivo binding of 77Br-p-bromospiroperidol in rat brain: a potential tool for gamma ray imaging. Life Sci. 28: 1911-1916.

Huang, C. C., Friedman, A. M., Rayudu, G. V., Clark, P., Fordham, E. W. 1980. In vivo stability and distribution of [131I]iodomethyl trimethylammonium chloride: concise communication. J Nucl Med. 21: 679-681.

Huang, C. C., Friedman, A. M., So, R., Simonovic, M., Meltzer, H. Y. 1980. Synthesis and biological evaluation of p-bromospiperone as potential neuroleptic drug. J Pharm Sci. 69: 984-986.

Gindler, J. E., Oselka, M. C., Friedman, A. M., Mayron, L. W., Kaplan, E. 1976. A gas target assembly for the production of high purity, high specific activity 81Rb. Int J Appl Radiat Isot. 27: 330-332.

Kaplan, E., Mayron, L. W., Friedman, A. M., Gindler, J. E., Frazin, L., Moran, J. M., Loeb, H., Gunnar, R. M. 1976. Definition of myocardial perfusion by continuous infusion of krypton-81m. Am J Cardiol. 37: 878-884.

Mayron, L. W., Kaplan, E., Friedman, A. M., Gindler, J. E. 1976. Head scintigraphy with krypton-81m. Int J Nucl Med Biol. 3: 35-36.

Mayron, L. W., Friedman, A. M., Kaplan, E., Gindler, J. E. 1975. A sterile, multicomponent 81Rb-81mKr minigenerator and delivery system. Int J Nucl Med Biol. 2: 141-142.

Mayron, L. W., Kaplan, E., Colombetti, L. G., Friedman, A. M., Gindler, J. E. 1975. A minigenerator for the production of krypton-81m and its applications. Int J Nucl Med Biol. 2: 40-42.

Mayron, L. W., Kaplan, E., Friedman, A. M., Gindler, J. E. 1975. The use of 81mKr in deglutition kinetic studies. Int J Nucl Med Biol. 2: 42-43.

Colombetti, L. G., Mayron, L. W., Kaplan, E., Barnes, W. E., Friedman, A. M., Gindler, J. E. 1974. Continuous radionuclide generation. I. Production and evaluation of a 81mKr minigenerator. J Nucl Med. 15: 868-873.

Kaplan, E., Mayron, L. W., Barnes, W. E., Colombetti, L. G., Friedman, A. M., Gindler, J. E. 1974. Continuous radionuclide generation. II. Scintigraphic definition of capillary exchange by rapid decay of 81mKr and its applications. J Nucl Med. 15: 874-879.

Mayron, L. W., Kaplan, E., Friedman, A. M., Gindler, J. E. 1974. Letter: The preparation of 81Rb in high specific activity quantities and its use in a 81Rb-81mKr generator. Int J Appl Radiat Isot. 25: 237-238.