Jimmy Dooley
Research Areas
Infants continually explore and interact with the world around them, and these experiences are critical for normal sensorimotor development. Although it’s generally assumed that the important movements occur while we’re awake, my lab’s research calls this assumption into question. Specifically, I’ve found that myoclonic twitches (brief movements produced during REM sleep) drive neural activity throughout the brain that, in turn, promotes sensorimotor integration and development. My lab aims to understand whether this twitch-related neural activity is necessary for the development of cortically-mediated motor control. To achieve this aim, I investigate brain-behavior relations in infant rats as they cycle between sleep and wake. My research uses a variety of methods, including multichannel neurophysiology, pharmacological and optogenetic manipulations, and state-of-the art behavioral analysis.
Education
A.B. in Biology and Psychology, University of Chicago, 2009
Ph.D. in Neuroscience, University of California, Davis, 2015
Worked in Leah Krubitzer’s laboratory
Postdoc at the University of Iowa, 2016-2022
Worked in Mark Blumberg’s laboratory
Selected Publications
Kobrossi JP3 and Dooley JC. (2026). The developmental emergence of tonic and phasic REM sleep in rats. The Journal of Neuroscience . E2176252026
Reid MR1*, Sattler NJ*, and Dooley JC. (2026). Motor cortex activity during sleep and wake movements sharpens across development but continues to lag the red nucleus. Scientific Reports . 16, 12872.
Blumberg MS, Myroth AG, Horton J, Pal S, Sokoloff G, Dooley JC. (2026). REM-sleep twitches and the maintenance of specialized sensorimotor systems across the lifespan. Current Biology . 36, R286-R298.
Dooley JC* and van der Heijden, ME*. (2024). More than a small brain: the importance of studying neural function during development. The Journal of Neuroscience . 44:e1367242024. PMC11604142
Blumberg MS*, Dooley JC*, and Tiriac, A*. (2022). Sleep, plasticity, and sensory neurodevelopment. Neuron . 110: 3230-3242. PMC9588561
Blumberg MS, Dooley JC, and Tiriac, A. ( In press ). Sleep, plasticity, and neurodevelopment. Neuron.
Dooley JC, Sokoloff G, and Blumberg, MS. (2021). Movements during sleep reveal the developmental emergence of a cerebellar-dependent internal model in motor thalamus. Current Biology . 31: 5501-5511.
Dooley JC, Glanz RM, Sokoloff G, and Blumberg MS (2020) Self-generated whisker movements drive state-dependent sensory input to developing barrel cortex. Current Biology . 30: 2404–2410. PMCID: PMC7314650
Dooley JC, Sokoloff G, and Blumberg MS (2019) Behavioral states modulate sensory processing in early development. Current Sleep Medicine Reports . 5: 112–117. PMCID: PMC6818957
Dooley JC, Blumberg MS (2018) Developmental "awakening" of primary motor cortex to the sensory consequences of movement. eLife . 7:e41841. PMCID: PMC6320070