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Laszlo Csonka Publications


Salvador, M., Agrandoña, M., Naranjo, E., Piubeli, F., Nieto, J. J., Csonka, L. N., Vargas, C. 2018. Quantitative RNA-seq analysis unveils osmotic and thermal adaptation mechanisms relevant for ectoine production in Chromohalobacter salexigensFront Microbiol. 9:1845 doi: 10.3389/fmicb.2018.01845

Gall, A. R., Hegarty, A. E., Datsenko, K. A., Westerman, R. P., SanMiguel, P., Csonka, L. N. 2018. High-level, constitutive expression of the mgtC gene confers increased thermotolerance on Salmonella enterica serovar Typhimurium. Mol Microbiol. 109:327-344. doi: 10.1111/mmi13988

Ebrahimi. A., Csonka, L. N., Alam, M. A. 2018. Analyzing thermal stability of cell membrane of Salmonella using time-multiplexed impedance sensing. Biophys. J. 114:1-10.

Gall, A. R., Datsenko, K. A., Figueroa-Bossi, N., Bossi, L., Masuda, I., Hou, Y.-M., Csonka, L. N. 2016. Mg2+ regulates transcription of mgtA in Salmonella Typhimurium via translation of proline codons during synthesis of the MgtL peptide. Proc Natl Acad Sci U S A. 113:15096-15101.

This article has been recognized in a commentary: Hughes, K. T. 2016. Mg2+-dependent translational speed bump acts to regulate gene transcription. Proc Natl Acad Sci U S A 113:14881-14883. doi: 10.1073/pnas.1618222114.

Fichman, Y., Gerdes, S. Y., Kovács, H., Szabados, L., Zilberstein, A., Csonka, L. N. 2015. Evolution of proline biosynthesis: enzymology, bioinformatics, genetics, and transcriptional regulation. Biol Rev Camb Philos Soc. 90:1065-1099.

Salvador, M., Argandoña, M., Pastor, J. M., Bernal, V., Cánovas, M., Csonka, L. N., Nieto, J. J., Vargas, C. 2015. Contribution of RpoS to metabolic efficiency and ectoines synthesis during the osmo- and heat-stress response in the halophilic bacterium Chromohalobacter salexigens. Environ Microbiol Rep. 7:301-311.

Duarte-Gómez, E. E., Graham, D., Budzik, M., Paxson, B., Csonka, L., Morgan, M., Applegate, B., San Martín-González, M. F. 2014. High hydrostatic pressure effects on bacterial bioluminescence. LWT - Food Science and Technology. 56:484-493.

Pastor, J. M., Bernal, V., Salvador, M., Argandoña, M., Vargas, C., Csonka, L., Sevilla, Á., Iborra, J. L., Nieto, J. J., Cánovas, M. 2013. Role of central metabolism in the osmoadaptation of the halophilic bacterium Chromohalobacter salexigens. J Biol Chem. 288:17769-17781.

Frossard, S. M., Khan, A. A., Warrick, E. C., Gately, J. M., Hanson, A. D., Oldham, M. L., Sanders, D. A., Csonka, L. N. 2012. Identification of a third osmoprotectant transport system, the OsmU system, in Salmonella enterica. J Bacteriol. 194:3861-3871.

Gasper, B. J., McCreight, J. C., Banschbach, K., Bustion, A., Davis, C., Divecha, R., Donoho, M., Elmore, A. G., Garrison, C. M., Glenn, S., Goeman, D. C., Haby, M., Hooks, T., Korman, A. M., Kowal, J., Kuschke, S., Mellencamp, J. E., Meyer, M., Myers, A. N., Nichols, M. F., Pfeifer, A., Porucznik, A., Qu, X., Ramos-Miller, M., Reed, R. R., Sagintayev, A., Singel, J. M., Smith, A., Valle, M. E., Venderley, A., Weber, C. A., Zaffino, A. J., Csonka, L. N., Gardner, S. M. 2012. Isolation and preliminary characterization of amino acid substitution mutations that increase the activity of the osmoregulated ProP protein of of Salmonella enterica serovar Typhimurium. DNA Cell Biol. 31:956-967.

Gasper, B. J., Minchella, D. J., Weaver, G. C., Csonka, L. N., Gardner, S. M. 2012. Adapting to osmotic stress and the process of science. Science. 335:1590-1591. (IBI* Series Winner)

Reina-Bueno, M., Argandoña, M., Salvador, M., Rodríguez-Moya, J., Iglesias-Guerra, F., Csonka, L. N., Nieto, J. J., Vargas, C. 2012. Role of trehalose in salinity and temperature tolerance in the model halophilic bacterium Chromohalobacter salexigens. PLoS One. 7:e33587.

Copeland, A., O'Connor, K., Lucas, S., Lapidus, A., Berry, K. W., Detter, J. C., Glavina Del Rio, G., Hammon, N., Dalin, E., Tice, H., Pitluck, S., Bruce, D., Goodwin, L., Han, C., Tapia, R., Saunders, E., Schmutz, J. Brettin, T., Larimer, F., Land, M., Hauser, L., Vargas, C., Nieto, J. J., Kyrpides, N. C., Ivanova, N., Göker, M., Klenk, H.-P., Csonak, L. N., Woyke, T. 2011. Complete genome sequence of the halophilic and highly halotolerant Chromohalobacter salexigens type strain (1H11T). Stand Genomic Sci. 5:379-388.

Stein, H., Honig, A., Miller, G., Erster, O., Eilenberg, H., Csonka, L. N., Szabados, L., Koncz, C., Zilberstein, A. 2011. Elevation of free proline and proline-rich protein levels by simultaneous manipulations of proline biosynthesis and degradation in plants. Plant Sci. 181:140-150.

Pastor, J. M., Salvador, M., Argandoña, M., Bernal, V., Reina-Bueno, M., Csonka, L. N., Iborra, J. L., Vargas, C., Nieto, J. J., Cánovas, M. 2010. Ectoines in cell stress protection: Uses and biotechnological production. Biotechnol Adv. 28:782-801.

O'Connor, K., Fletcher, S. A., Csonka, L. N. 2009. Increased expression of Mg2+ transport proteins enhances the survival of Salmonella enterica at high temperature. Proc Natl Acad Sci U S A. 106:17522-17527.

Gunasekera, T. S., Csonka, L. N., Paliy, O. 2008. Genome-wide transcriptional responses of Escherichia coli K-12 to continuous osmotic and heat stresses. J Bacteriol. 190:3712-3720.

Csonka, L. N., Leisinger, T. 2007. Biosynthesis of proline. EcoSal Plus. doi:10.1128/ecosalplus.

Krichevsky, A., Smith, M. J., Whitman, L. J., Johnson, M. B., Clinton, T. W., Perry, L. L., Applegate, B. M., O'Connor, K., Csonka, L. N. 2007. Trapping motile magnetotactic bacteria with a magnetic recording head. J. Appl. Phys. 101:014701-014701-6.

García-Estepa, R., Cánovas, D., Iglesias-Guerra, F., Ventosa, A., Csonka, L. N., Nieto, J. J., Vargas, C. 2006. Osmoprotection of Salmonella enterica serovar Typhimurium by Nγ-acetyldiaminobutyrate, the precursor of the compatible solute ectoine. Syst Appl Microbiol. 29:626-633.

Smith, M. J., Sheehan, P. E., Perry, L. L., O'Connor, K., Csonka, L. N., Applegate, B. M., Whitman, L. J. 2006. Quantifying the magnetic advantage in magnetotaxis. Biophys. J. 91:1098-1107.

Balaji, B., O'Connor, K., Lucas, J. R., Anderson, J. M., Csonka, L. N. 2005. Timing of induction of osmotically controlled genes in Salmonella enterica Serovar Typhimurium, determined with quantitative real-time reverse transcription-PCR. Appl Environ Microbiol. 71:8273-8283.

Oren, A., Larimer, F., Richardson, P., Lapidus, A., Csonka, L. N. 2005. How to be moderately halophilic with broad salt tolerance: clues from the genome of Chromohalobacter salexigens. Extremophiles. 9:275-279.

Calderón, M. I., Vargas, C., Rojo, F., Iglesias-Guerra, F., Csonka, L. N., Ventosa, A., Nieto, J. J. 2004. Complex regulation of the synthesis of the compatible solute ectoine in the halophilic bacterium Chromohalobacter salexigens DSM 3043T. Microbiology. 150:3051-3063.

O'Connor, K., Csonka, L. N. 2003. The high salt requirement of the moderate halophile Chromohalobacter salexigens DSM3043 can be met not only by NaCl but by other ions. Appl Environ Microbiol. 69:6334-6336.

Fujita, T., Maggio, A., García-Ríos, M., Stauffacher, C., Bressan, R. A., Csonka, L. N. 2003. Identification of regions of the tomato γ-glutamyl kinase that are involved in allosteric regulation by proline. J Biol Chem. 278:14203-14210.

Wood, J. M., Bremer, E., Csonka, L. N., Kraemer, R., Poolman, B., van der Heide, T., Smith, L. T. 2001. Osmosensing and osmoregulatory compatible solute accumulation by bacteria. Comp Biochem Physiol A Mol Integr Physiol. 130:437-460.

Cánovas, D., Fletcher, S. A., Hayashi, M., Csonka, L. N. 2001. Role of trehalose in growth at high temperature of Salmonella enterica serovar Typhimurium. J Bacteriol. 183:3365-3371.

Fletcher, S. A., Rhodes, D., Csonka, L. N. 2001. Analysis of the effects of osmoprotectants on the high osmolality-dependent induction of increased thermotolerance in Salmonella typhimurium. Food Microbiol. 18:345-354.

Kültz, D., Csonka, L. 1999. What sets the TonE during osmotic stress?. Proc Natl Acad Sci U S A. 96:1814-1816.

Cánovas, D., Vargas, C., Csonka, L. N., Ventosa, A., Nieto, J. J. 1998. Synthesis of glycine betaine from exogenous choline in the moderately halophilic bacterium Halomonas elongata. Appl Environ Microbiol. 64:4095-4097.

Fujita, T., Maggio, A., Garcia-Rios, M., Bressan, R. A., Csonka, L. N. 1998. Comparative analysis of the regulation of expression and structures of two evolutionarily divergent genes for Δ1-pyrroline-5-carboxylate synthetase from tomato. Plant Physiol. 118:661-674.

Fletcher, S. A., Csonka, L. N. 1998. Characterization of the induction of increased thermotolerance by high osmolarity in Salmonella. Food Microbiol. 15:307-317.

Cánovas, D., Vargas, C., Iglesias-Guerra, F., Csonka, L. N., Rhodes, D., Ventosa, A., Nieto, J. J. 1997. Isolation and characterization of salt-sensitive mutants of the moderate halophile Halomonas elongata and cloning of the ectoine synthesis genes. J Biol Chem. 272:25794-25801.

García-Ríos, M., Fujita, T., LaRosa, P. C., Locy, R. D., Clithero, J. M., Bressan, R. A., Csonka, L. N. 1997. Cloning of a polycistronic cDNA from tomato encoding γ-glutamyl kinase and γ-glutamyl phosphate reductase. Proc Natl Acad Sci U S A. 94:8249-8254.

Frymier, J. S., Reed, T. D., Fletcher, S. A., Csonka, L. N. 1997. Characterization of transcriptional regulation of the kdp operon of Salmonella typhimurium. J Bacteriol. 179:3061-3063.

Cánovas, D., Vargas, C., Csonka, L. N., Ventosa, A., Nieto, J. J. 1996. Osmoprotectants in Halomonas elongata: High-affinity betaine transport system and choline-betaine pathway. J Bacteriol. 178:7221-7226.

Zhang, X., Fletcher, S. A., Csonka, L. N. 1996. Site-directed mutational analysis of the osmotically regulated proU promoter of Salmonella typhimurium. J Bacteriol. 178:3377-3379.

Fletcher, S. A., Csonka, L. N. 1995. Fine-structure deletion analysis of the transcriptional silencer of the proU operon of Salmonella typhimurium. J Bacteriol. 177:4508-4513.

Gutierrez, J. A., Csonka, L. N. 1995. Isolation and characterization of adenylate kinase (adk) mutations in Salmonella typhimurium which block the ability of glycine betaine to function as an osmoprotectant. J Bacteriol. 177:390-400.

Csonka, L. N., Ikeda, T. P., Fletcher, S. A., Kustu, S. 1994. The accumulation of glutamate is necessary for optimal growth of Salmonella typhimurium in media of high osmolality but not induction of the proU operon. J Bacteriol. 176:6324-6333.

Overdier, D. G., Csonka, L. N. 1992. A transcriptional silencer downstream of the promoter in the osmotically controlled proU operon of Salmonella typhimurium. Proc Natl Acad Sci U S A. 89:3140-3144.

LaRosa, P. C., Rhodes, D., Rhodes, J. C., Bressan, R. A., Csonka, L. N. 1991. Elevated accumulation of proline in NaCl-adapted tobacco cells is not due to altered Δ1-pyrroline-5-carboxylate reductase. Plant Physiol. 96:245-250.

Csonka, L. N., Hanson, A. D. 1991. Prokaryotic osmoregulation: Genetics and physiology. Annu Rev Microbiol. 45:569-606.

Overdier, D. G., Olson, E. R., Erickson, B. D., Ederer, M. M., Csonka, L. N. 1989. Nucleotide sequence of the transcriptional control region of the osmotically regulated proU operon of Salmonella typhimurium and identification of the 5′ endpoint of the proU mRNA. J Bacteriol. 171:4694-4706.

Csonka, L. N. 1989. Physiological and genetic responses of bacteria to osmotic stress. Microbiol Rev. 53:121-147.

Brady, R. A., Csonka, L. N. 1988. Transcriptional regulation of the proC gene of Salmonella typhimurium. J Bacteriol. 170:2379-2382.

Csonka, L. N. 1988. Regulation of cytoplasmic proline levels in Salmonella typhimurium: Effect of osmotic stress on synthesis, degradation, and cellular retention of proline. J Bacteriol. 170:2374-2378.

Csonka, L. N., Gelvin, S. B., Goodner, B. W., Orser, C. S., Siemieniak, D., Slightom, J. L. 1988. Nucleotide sequence of a mutation in the proB gene of Escherichia coli that confers proline overproduction and enhanced tolerance to osmotic stress. Gene. 64:199-205.

Orser, C. S., Goodner, B. W., Johnston, M., Gelvin, S. B., Csonka, L. N. 1988. The Escherichia coli proB gene corrects the proline auxotrophy of Saccharomyces cerevisiae pro1 mutants. Mol Gen Genet. 212:124-128.

Druger-Liotta, J., Prange, V. J., Overdier, D. G., Csonka, L. N. 1987. Selection of mutations that alter the osmotic control of transcription of the Salmonella typhimurium proU operon. J Bacteriol. 169:2449-2459.

Dunlap, V. J., Csonka, L. N. 1985. Osmotic regulation of L-proline transport in Salmonella typhimurium. J Bacteriol. 163:296-304.

Mahan, M. J., Csonka, L. N. 1983. Genetic analysis of the proBA genes of Salmonella typhimurium: physical and genetic analyses of the cloned proB+ A+ genes of Escherichia coli and of a mutant allele that confers proline overproduction and enhanced osmotolerance. J Bacteriol. 156:1249-1262.

Le Rudulier, D., Yang, S. S., Csonka, L. N. 1982. Nitrogen fixation in Klebsiella pneumoniae during osmotic stress. Effect of exogenous proline or a proline overproducing plasmid. Biochim Biophys Acta. 719:273-283.

Csonka, L. N. 1982. A third L-proline permease in Salmonella typhimurium which functions in media of elevated osmotic strength. J Bacteriol. 151:1433-1443.

Csonka, L. N. 1981. Proline over-production results in enhanced osmotolerance in Salmonella typhimurium. Mol Gen Genet. 182:82-86.

Csonka, L. N. 1981. The role of proline in osmoregulation in Salmonella typhimurium and Escherichia coli. In: Trends in the Biology of Fermentations for Fuels and Chemicals, Hollaender, A., Rbson, R., Rogers, P., Pietro, A. S., Valentine, R., Wolfe, R., Eds., Springer US: Boston, MA, pp. 533-542.

Csonka, L. N., Howe, M. M., Ingraham, J. L., Pierson, L. S. 3rd, Turnbough, C. L., Jr. 1981. Infection of Salmonella typhimurium with coliphage Mu d1 (Apr lac): construction of pyr::lac gene fusions. J Bacteriol. 145:299-305.

Vadasz, K., Csonka, L. 1981. [The value of peritoneal lavage in the diagnosis of closed abdominal injury (authors transl)]. Magy Traumatol Orthop Helyreallito Seb. 24:268-273.

Csonka, L. N., Clark, A. J. 1980. Construction of an Hfr strain useful for transferring recA mutations between Escherichia coli strains. J Bacteriol. 143:529-530.

Csonka, L., Vadász, K. 1980. [Late diagnosis of isolated single stage traumatic splenic rupture]. Orv Hetil. 121:1279-1280. [Article in Hungarian]

Andersen, K., Shanmugam, K. T., Lim, S. T., Csonka, L. N., Tait, R., Hennecke, H., Scott, D. B., Hom, S. S. M., Haury, J. F., Valentine, A., Valentine, R. C. 1980. Genetic engineering in agriculture with emphasis on nitrogen fixation. Trends Biochem Sci. 5:35-39.

Csonka, L. N., Clark, A. J. 1979. Deletions generated by the transposon Tn10 in the srl recA region of the Escherichia coli K-12 chromosome. Genetics. 93:321-343.

Csonka, L. N. 1977. Use of 3H and 14C double-labeled glucose to assess in vivo pathways of amino acid biosynthesis in Escherichia coli. J Biol Chem. 252:3392-3398.

Csonka, L. N., Fraenkel, D. G. 1977. Pathways of NADPH formation in Escherichia coli. J Biol Chem. 252:3382-3391.

Coppens, P., Willoughby, T. V., Csonka, L. N. 1971. Electron population analysis of accurate diffraction data. I. Formalisms and restrictions. Acta Crystallogr. A27:248-256.

Coppens, P., Csonka, L., Willoughby, T. V. 1970. Electron population parameters from least-squares refinement of x-ray diffraction data. Science. 167:1126-1128.

May, M., Czoncka (Csonka), L., Garrison, D. R., Triggle, D. J. 1968. The analgesic, hypothermic, and depressant activities of some N-substituted α-5,9-dimethyl-6,7-benzomorphans. J Pharm Sci. 57:884-887.

Book Section

Csonka, L. N., O'Connor, K., Larimer, F., Richardson, P., Lapidus, A., Ewing, A. D., Goodner, B. W., Oren, A. 2005. What we can deduce about metabolism in the moderate halophile Chromohalobacter salexigens from its genomic sequence. In: Adaptation to Life at High Salt Concentrations in Archaea, Bacteria, and Eukarya. Cellular Origin, Life in Extreme Habitats and Astrobiology, Gunde-Cimerman, N., Oren, A., Plemenitaš, A., Eds., Springer, Dordrecht. Vol. 9:269-285.

Csonka, L. N., Epstein, W. 1996. Osmoregulation. In: Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd Edn, Neidhardt, F. C., Ed., American Society of Microbiology, Washington, DC, pp. 1210-1223.

Samaras, Y., Bressan, R. A., Csonka, L. N., García-Ríos, M. G., Paino D'Urzo, M., Rhodes, D. 1995. Proline accumulation during drought and salinity. In: Environment and Plant Metabolism: Flexibility and Acclimation, Smirnoff, N., Ed., BIOS Scientific Publishers Ltd., Oxford, pp. 161-187.

García-Ríos, M. G., Csonka, L. N., Bressan, R. A., LaRosa, P. C., Hanquier, J. 1994. Cloning of a DNA fragment encoding γ-glutamyl kinase and γ-glutamyl phosphate reductase from a tomato cDNA library. In: Biochemical and Cellular Mechanisms of Stress Tolerance in Plants, NATO ASI Series, Cherry, J. H., Ed., Springer Berlin Heidelberg: Berlin, Heidelberg, pp. 245-254.

Gutierrez, J. A., Csonka, L. N. 1993. The involvement of adenylate kinase in the utilization of glycinebetaine as an osmoprotectant in Salmonella typhimurrium. In: Plant Responses to Cellular Dehydration During Environmental Stress, Close, T. J., Bray, E. A., Eds., The American Society of Plant Physiologists, Riverside, CA., pp. 21-28.

Overdier, D. G., Fletcher, S., Csonka, L. N. 1992. Osmotic control of transcription of the proU operon of Salmonella typhimurium. In: Water and Life: Comparative Analysis of Water Relationships at the Organismic, Cellular, and Molecular Levels, Somero, G. N., Osmond, C. B., Bolis, C. L., Eds., Springer Berlin Heidelberg, pp. 61-69.

Gutierrez, J. A., Csonka, L. N. 1989. Salmonella typhimurium mutants that are not stimulated by glycinebetaine in media of elevated osmolarity. In: Environmental Stress in Plants: Biochemical and Physiological Mechanisms, Cherry, J. H., Ed., Springer Berlin Heidelberg: Berlin, Heidelberg, pp.89-98.

Dunlap, V. J., Csonka, L. N. 1985. Regulation of the osmotically stimulated transport of proline and glycinebetaine in Salmonella typhimurium. In: Cellular and Molecular Biology of Plant Stress, Key, J. L., Kosuge, T., Eds., Alan R. Liss, Inc., New York. pp. 115-128.

Csonka, L. N, Baich, A. 1983. Proline biosynthesis. In: Amino Acids Biosynthesis and Genetic Regulation, Herrmann, K. M., Somerville, R. L., Eds., Reading, MA: Addison-Wesley Co., pp. 35-51.

Rains, D. W., Csonka, L., LeRudulier, D., Croughan, T. P., Yang, S. S., Stavarek, S. J., Valentine, R.C. 1982. Osmoregulation by organisms exposed to saline stress: Physiological mechanisms and genetic manipulation. In: Biosaline Research: A Look to the Future, Pietro, A. S., Ed., Plenum Publishing Corporation, New York, pp. 283-302.

Csonka, L. N. 1979. The role of L-proline in response to osmotic stress in Salmonella typhimurium: selection of mutants with increased osmotolerance as strains which over-produce L-proline. In: Genetic Engineering of Osmoregulation: Impact on Plant Productivity for Food, Chemicals, and Energy, Rains, D. W., Valentine, R. C., Hollaender A., Eds., Springer US: Boston, MA, Basic Life Sci. 14:35-52.

Conference Proceedings

Csonka, L. N. 1990. The influence of water potential on plant-microbe interactions. In: Proceedings of the International Symposium on Biotic Stress of Barley in Arid and Semi-Arid Environments, Riesselman, J., Ed., Montana State University, Boseman, pp. 29-31.


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