Owen Andrews

Owen Andrews is a postdoctoral research associate at the Broad Institute of MIT and Harvard. He received his PhD in Physics from MIT, where he used live-cell super-resolution microscopy to study the dynamic organization of transcriptional machinery. He now combines high-throughput quantitative microscopy with pooled CRISPR perturbations to identify genes that modify disease-associated cellular phenotypes, with the goal of nominating therapeutic targets for rare diseases. His work established optical pooled screening in human stem cell-derived neurons, and he recently completed a genome-wide CRISPR interference screen for modifiers of TDP-43 mislocalization and splicing dysfunction, hallmarks of ALS pathology, in patient-derived neurons.