Mattoo Lab

Purdue Department of Biological Sciences

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Regulation of cell signaling by Fic-mediated post-translational modifications

Fic (filamentation induced by cAMP) proteins are a newly discovered family of enzymes that carry out diverse post-translational modifications, predominantly adenylylation/AMPylation – i.e., the covalent attachment of AMP (adenosine monophosphate) to the target protein – to alter cellular signaling.  The Mattoo Lab takes a multidisciplinary approach to studying the functional repertoire of Fic  proteins in prokaryotic and eukaryotic signal transduction. 

Bacterial pathogenesis Eukaryotic stress homeostasis & disease