Research

Our lab studies microRNAs and angiosarcomas which are aggressive vascular sarcomas from blood and lymphatic endothelial cells. Despite the extremely poor prognosis for patients, the genetic drivers and molecular mechanisms of these tumors remain unclear. In recent work, we found that Dicer1 and microRNAs may function as critical tumor suppressors. We have gone on to generate additional tumor models investigating other genes known to be altered in patients. We leverage these genetic models to study tumor initiation, progression, and metastasis in vivo and in cell line models.