Population Genetics

  1. Balaresque P, Poulet N, Cussat-Blanc S, Gerard P, Quintana-Murci L, Heyer E, Jobling MA. Y-chromosome descent clusters and male differential reproductive success: young lineage expansions dominate Asian pastoral nomadic populations. Eur J Hum Genet. 2015 Jan 14. doi: 10.1038/ejhg.2014.285. [Epub ahead of print] PubMed PMID: 25585703.

Evolution

  1. Head JJ, Polly PD. Evolution of the snake body form reveals homoplasy in amniote Hox gene function. Nature. 2015 Jan 5. doi: 10.1038/nature14042. [Epub ahead of print] PubMed PMID: 25539083.
  2. Lewis SL, Maslin MA. Defining the anthropocene. Nature. 2015 Mar 12;519(7542):171-80. doi: 10.1038/nature14258. PubMed PMID: 25762280.

Research Career

  1. 10 things not enough kids know before going to college
  2. Powell K. The future of the postdoc. Nature. 2015 Apr 9;520(7546):144-7. doi: 10.1038/520144a. PubMed PMID: 25855437.
  3. Will declining funding stunt scientific discovery in the U.S.?
  4. Who Picks Up the Tab for Science?

Imaging

  1. Chen F, Tillberg PW, Boyden ES. Optical imaging. Expansion microscopy. Science. 2015 Jan 30;347(6221):543-8. doi: 10.1126/science.1260088. Epub 2015 Jan 15. PubMed PMID: 25592419; PubMed Central PMCID: PMC4312537.

Medicine

  1. Leinenga G, Götz J. Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model. Sci Transl Med. 2015 Mar 11;7(278):278ra33. doi: 10.1126/scitranslmed.aaa2512. PubMed PMID: 25761889.
    1. New Alzheimer’s treatment fully restores memory function
  2. Kawchuk GN, Fryer J, Jaremko JL, Zeng H, Rowe L, Thompson R. Real-time visualization of joint cavitation. PLoS One. 2015 Apr 15;10(4):e0119470. doi: 10.1371/journal.pone.0119470. eCollection 2015. PubMed PMID: 25875374; PubMed Central PMCID: PMC4398549.
  3. Ganna A, Ingelsson E. 5 year mortality predictors in 498 103 UK Biobank participants: a prospective population-based study. Lancet. 2015 Jun 2. pii: S0140-6736(15)60175-1. doi: 10.1016/S0140-6736(15)60175-1. [Epub ahead of print] PubMed PMID: 26049253.

Medicine/Prosthetics

  1. Men have hands amputated and replaced with bionic ones
  2. Lab In Berkeley Accidentally Discovers Solution To Fix Color Blindness

Chemistry

  1. This Chemistry 3D Printer Can Synthesize Molecules From Scratch

Genomics

  1. Ji X, Dadon DB, Abraham BJ, Lee TI, Jaenisch R, Bradner JE, Young RA. Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions. Proc Natl Acad Sci U S A. 2015 Mar 9. pii: 201502971. [Epub ahead of print] PubMed PMID: 25755260.
  2. Chen KH, Boettiger AN, Moffitt JR, Wang S, Zhuang X. Spatially resolved, highly multiplexed RNA profiling in single cells. Science. 2015 Apr 9. pii: aaa6090. PubMed PMID: 25858977.

General

  1. Baden T, Chagas AM, Gage G, Marzullo T, Prieto-Godino LL, Euler T. Open labware: 3-d printing your own lab equipment. PLoS Biol. 2015 Mar 20;13(3):e1002086. doi: 10.1371/journal.pbio.1002086. eCollection 2015 Mar. PubMed PMID: 25794301.

Development

  1. Campbell PD, Chao JA, Singer RH, Marlow FL. Dynamic visualization of transcription and RNA subcellular localization in zebrafish. Development. 2015 Mar 10. pii: dev.118968. [Epub ahead of print] PubMed PMID: 25758462.
  2. Green JB, Sharpe J. Positional information and reaction-diffusion: two big ideas in developmental biology combine. Development. 2015 Apr 1;142(7):1203-1211. Review. PubMed PMID: 25804733.
  3. Wu F, Kaczynski TJ, Sethuramanujam S, Li R, Jain V, Slaughter M, Mu X. Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc Natl Acad Sci U S A. 2015 Mar 16. pii: 201421535. [Epub ahead of print] PubMed PMID: 25775587.
  4. Nern A, Pfeiffer BD, Rubin GM. Optimized tools for multicolor stochastic labeling reveal diverse stereotyped cell arrangements in the fly visual system.Proc Natl Acad Sci U S A. 2015 May 11. pii: 201506763. [Epub ahead of print] PubMed PMID: 25964354.

Neuroscience

  1. Lichtman JW, Pfister H, Shavit N. The big data challenges of connectomics. Nat Neurosci. 2014 Nov;17(11):1448-54. doi: 10.1038/nn.3837. Epub 2014 Oct 28. Review. PubMed PMID: 25349911.
  2. Hayworth KJ, Xu CS, Lu Z, Knott GW, Fetter RD, Tapia JC, Lichtman JW, Hess HF.
    Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics. Nat Methods. 2015 Apr;12(4):319-22. doi: 10.1038/nmeth.3292. Epub 2015 Feb 16. PubMed PMID: 25686390; PubMed Central PMCID: PMC4382383.
  3. Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, Tsai LH. Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes. Cell. 2015 Jun 18;161(7):1592-605. doi: 10.1016/j.cell.2015.05.032. Epub 2015 Jun 4. PubMed PMID: 26052046.

Genetics/Genome Editing

  1. Yin L, Maddison LA, Li M, Kara N, LaFave MC, Varshney GK, Burgess SM, Patton JG, Chen W. Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs. Genetics. 2015 Apr 8. pii: genetics.115.176917. [Epub ahead of print] PubMed PMID: 25855067.
  2. Gonzales AP, Yeh JR. Cas9-based genome editing in zebrafish. Methods Enzymol. 2014;546:377-413. doi: 10.1016/B978-0-12-801185-0.00018-0. PubMed PMID: 25398350.
  3. Shah AN, Davey CF, Whitebirch AC, Miller AC, Moens CB. Rapid reverse genetic screening using CRISPR in zebrafish. Nat Methods. 2015 Jun;12(6):535-40. doi: 10.1038/nmeth.3360. Epub 2015 Apr 13. PubMed PMID: 25867848.
  4. Dow LE, Fisher J, O’Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci ND, Lowe SW. Inducible in vivo genome editing with CRISPR-Cas9. Nat Biotechnol. 2015 Apr;33(4):390-4. doi: 10.1038/nbt.3155. Epub 2015 Feb 18. PubMed PMID: 25690852; PubMed Central PMCID: PMC4390466.

Prahatha Venkatraman and Yuk Fai Leung led a Development and Disease Research Lab section in the 13th USA Biology Olympiad Finals at Purdue University and shared our lab research on eye drug discovery using the zebrafish model. The students also learned essential basic skills for zebrafish research.

 

 

 

 

 

Prahatha Venkatraman and Yuk Fai Leung attended the 2015 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) in Denver, CO, from 5/3 5/7.

ARVO 2015

ARVO 2015

Prahatha presented a poster entitled “Understanding the contribution of photoreceptors to the visual motor response”.

Prahatha and Fai

Prahatha presenting her poster to colleagues, including Dr. Stephan Neuhauss on the left.

Lue Xiang, a former visiting scholar in the laboratory, also attended the meeting and presented a poster entitled “Charaterization of a retinitis pigmentosa gene slc7a14 in zebrafish by expression analysis and targeted deletion with CRISPR-Cas”.

Lue

Lilly Hall of Science; 2015 Purdue Spring Fest

Prahatha Venkatraman showing the way to measure fish vision to a future scientist.

Martian Tian explaining how to use zebrafish for eye disease research to the Lafayette community.

On 3/21, several lab members attended the 130th Annual Academy Meeting for the Indiana Academy of Science. The participants were: Meng She, Zain Abedali, Martin Tian, Ryan Wyer, Sylvia Bonilla, Prahatha Venkatraman and Yuk Fai Leung. Meng, Zain and Martin presented a poster of their undergraduate research work under the supervision of graduate students Sylvia and Prahatha. Here are a few pictures of the event.

Leung Lab and Dr. Chris Sahley at the IAS Annual Meeting.

Leung Lab the selfie style!

Martin Tian

Martin presenting his work.

Zain Abedali

Zain presenting his work.

Meng She

Meng presenting her poster.

Undergraduate students: Meng, Zain, Ryan Wyer, and Martin

Meng, Sylvia Bonilla (their research mentor), and Martin.

Zain, Prahatha Venkatraman (their research mentor), Ryan.

 

On 3/18, students from Jefferson high school in Lafayette visited our department. They were hosted by the Leung Lab. See our departmental news for the details of the visit. Here are several pictures of the event.

Prahatha Venkatraman giving students a lecture on zebrafish research.

Prahatha Venkatraman and Isidore Julien showing students how to observe developing zebrafish embryos.

Dr. Clark Gedney described the research opportunities in our department for high school students.

Isidore Julien discussing with Dr. Melissa George about student learning experience.

Yuk Fai Leung showing students how to observe zebrafish embryos.

Students studying zebrafish embryos—I.

Students studying zebrafish embryos—II.

Best Advice: What You Want to Do Isn’t Always What You Want to Be

Cancer

  1. Tomasetti C, Vogelstein B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 2015 Jan 2;347(6217):78-81. doi: 10.1126/science.1260825. PubMed PMID: 25554788.

Zebrafish

  1. Kok FO, Shin M, Ni CW, Gupta A, Grosse AS, van Impel A, Kirchmaier BC, Peterson-Maduro J, Kourkoulis G, Male I, DeSantis DF, Sheppard-Tindell S, Ebarasi L, Betsholtz C, Schulte-Merker S, Wolfe SA, Lawson ND. Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Dev Cell. 2015 Jan 12;32(1):97-108. doi: 10.1016/j.devcel.2014.11.018. Epub 2014 Dec 18. PubMed PMID: 25533206.

Imaging

  1. Callaway E. Blown-up brains reveal nanoscale details. Nature. 2015 Jan 15;517(7534):254. doi: 10.1038/nature.2015.16667. PubMed PMID: 25592513.

Genetics

  1. Gurdasani D, Carstensen T, Tekola-Ayele F, Pagani L, Tachmazidou I, Hatzikotoulas K, Karthikeyan S, Iles L, Pollard MO, Choudhury A, Ritchie GR, Xue Y, Asimit J, Nsubuga RN, Young EH, Pomilla C, Kivinen K, Rockett K, Kamali A, Doumatey AP, Asiki G, Seeley J, Sisay-Joof F, Jallow M, Tollman S, Mekonnen E, Ekong R, Oljira T, Bradman N, Bojang K, Ramsay M, Adeyemo A, Bekele E, Motala A, Norris SA, Pirie F, Kaleebu P, Kwiatkowski D, Tyler-Smith C, Rotimi C, Zeggini E, Sandhu MS. The African Genome Variation Project shapes medical genetics in Africa. Nature. 2015 Jan 15;517(7534):327-32. doi: 10.1038/nature13997. Epub 2014 Dec 3. PubMed PMID: 25470054; PubMed Central PMCID: PMC4297536.
  2. Jens M, Rajewsky N. Competition between target sites of regulators shapes post-transcriptional gene regulation. Nat Rev Genet. 2015 Feb;16(2):113-26. doi: 10.1038/nrg3853. Epub 2014 Dec 9. PubMed PMID: 25488579.
  3. Ritchie MD, Holzinger ER, Li R, Pendergrass SA, Kim D. Methods of integrating data to uncover genotype-phenotype interactions. Nat Rev Genet. 2015 Feb;16(2):85-97. doi: 10.1038/nrg3868. Epub 2015 Jan 13. PubMed PMID: 25582081.

Genome-editing

  1. Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA. Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds. Cell. 2015 Jan 15;160(1-2):339-50. doi: 10.1016/j.cell.2014.11.052. Epub 2014 Dec 18. PubMed PMID: 25533786; PubMed Central PMCID: PMC4297522.

Development

  1. Singh AP, Nüsslein-Volhard C. Zebrafish Stripes as a Model for Vertebrate Colour Pattern Formation. Curr Biol. 2015 Jan 19;25(2):R81-R92. doi: 10.1016/j.cub.2014.11.013. Review. PubMed PMID: 25602311.
  2. Hiscock TW, Megason SG. Mathematically guided approaches to distinguish models of periodic patterning. Development. 2015 Feb 1;142(3):409-419. Review. PubMed PMID: 25605777; PubMed Central PMCID: PMC4302999.