At Purdue, five zebrafish laboratories (Qing Deng, Daniel Suter, Yuk Fai Leung, David Umulis, Guangjun Zhang) have a joint lab meeting called FLAME (zebraFish LAb MEeting). We not only meet regularly to discuss science, but we also have fun together. On 5/13/2019, we concluded another productive year by hiking together at the Turkey Run State Park.

The FLAME group

The Flame Group

Fai leading the younger generation.

 

Logan climbing up the (academic) ladder.

Fai and Isaac!

 

Emre attended the Purdue Undergraduate Research Conference 2019 and presented a poster entitled “Investigating Inhibition of Apoptosis as a Novel Treatment for Retinitis Pigmentosa using a Transgenic Zebrafish Model”.

Emre presenting his work at the Purdue Undergraduate Research Conference.

 

Emre Coskun, Rebecca James, Logan Ganzen, Truc Kha and Yuk Fai Leung attended the 134th Annual Meeting for the Indiana Academy of Science in Indianapolis, IN on March 30th, 2019. All students presented at the meeting.

The Leung Lab!

Logan Ganzen, our graduate student, presented his work identifying a FDA-approved drug for treating night blindness.

Logan presenting his work.

Emre Coskun (right) presented his work on “Investigating Inhibition of Apoptosis as a Novel Treatment for Retinitis Pigmentosa using a Transgenic Zebrafish Model”.

 

Rebecca James presented her work on “Utilization of a Zebrafish Visual Motor Response Assay to Discover FDA Approved Drugs to Treat Retinitis Pigmentosa”

 

On 11/12/2018, Emre Coskun attended the Purdue Fall Undergraduate Research Exposition and presented a poster of his undergraduate reserarch work on “A Pharmacological Model of TRPA1-Mediated Nociception in the Zebrafish for Therapeutic Discovery”. This project was conceived by our graduate student Logan Ganzen. Logan and Emre worked closely to develop the foundation of this research project, and established zebrafish as a model for screening drugs to alleviate pain in patients.

Emre presenting his undergraduate research work.

 

On 11/10/2018, Logan Ganzen and Yuk Fai Leung attended the 2018 Sensorium at Purdue University. Logan gave a talk on “Drug Screening and Hit Identification for Retinitis Pigmentosa with Zebrafish” and shared our latest discoveries on using zebrafish to find new drugs to treat night blindness.

Logan described how we used zebrafish model of night blindness to screen and find new drugs to treat the disease.

Logan described the therapeutic effect of a positive compound that he identified in his doctoral research.

 

ELSI

  1. Shotton D. Funders should mandate open citations. Nature. 2018 Jan 11;553(7687):129. doi: 10.1038/d41586-018-00104-7. PubMed PMID: 29323317.
  2. Lavazza A, Massimini M. Cerebral organoids: ethical issues and consciousness assessment. J Med Ethics. 2018 Feb 28. pii: medethics-2017-104555. doi: 10.1136/medethics-2017-104555. [Epub ahead of print] PubMed PMID: 29491041.

Genome Editing

  1. Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY, Liu DR. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. 2018 Jan 11;553(7687):217-221. doi: 10.1038/nature25164. Epub 2017 Dec 20. PubMed PMID: 29258297.
  2. Urnov F. An ode to gene edits that prevent deafness. Nature. 2018 Jan 11;553(7687):162-163. doi: 10.1038/d41586-017-08645-z. PubMed PMID: 29323325.

Development

  1. Nowoshilow S, Schloissnig S, Fei JF, Dahl A, Pang AWC, Pippel M, Winkler S, Hastie AR, Young G, Roscito JG, Falcon F, Knapp D, Powell S, Cruz A, Cao H, Habermann B, Hiller M, Tanaka EM, Myers EW. The axolotl genome and the evolution of key tissue formation regulators. Nature. 2018 Jan 24. doi: 10.1038/nature25458. [Epub ahead of print] PubMed PMID: 29364872.
  2. Harland RM. A new view of embryo development and regeneration. Science. 2018 Jun 1;360(6392):967-968. doi: 10.1126/science.aat8413. PubMed PMID: 29853675.
  3. Rozario T, Newmark PA. Prospecting for Planarian Pluripotency. Cell. 2018 Jun 14;173(7):1566-1567. doi: 10.1016/j.cell.2018.05.062. PubMed PMID: 29906442.
  4. Zeng A, Li H, Guo L, Gao X, McKinney S, Wang Y, Yu Z, Park J, Semerad C, Ross E, Cheng LC, Davies E, Lei K, Wang W, Perera A, Hall K, Peak A, Box A, Sánchez Alvarado A. Prospectively Isolated Tetraspanin(+) Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration. Cell. 2018 Jun 14;173(7):1593-1608.e20. doi: 10.1016/j.cell.2018.05.006. PubMed PMID: 29906446.

Stem cells

  1. Cyranoski D. How human embryonic stem cells sparked a revolution. Nature. 2018 Mar 22;555(7697):428-430. doi: 10.1038/d41586-018-03268-4. PubMed PMID: 29565377.
  2. da Cruz L, Fynes K, Georgiadis O, Kerby J, Luo YH, Ahmado A, Vernon A, Daniels JT, Nommiste B, Hasan SM, Gooljar SB, Carr AF, Vugler A, Ramsden CM, Bictash M, Fenster M, Steer J, Harbinson T, Wilbrey A, Tufail A, Feng G, Whitlock M, Robson AG, Holder GE, Sagoo MS, Loudon PT, Whiting P, Coffey PJ. Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol. 2018 Mar 19. doi: 10.1038/nbt.4114. [Epub ahead of print] PubMed PMID: 29553577.

Neuroscience

  1. Telley L, Jabaudon D. A mixed model of neuronal diversity. Nature. 2018 Mar 22;555(7697):452-454. doi: 10.1038/d41586-018-02539-4. PubMed PMID: 29565398. Science career
  2. Powell K. How to sail smoothly from academia to industry. Nature. 2018 Mar 22;555(7697):549-551. doi: 10.1038/d41586-018-03306-1. PubMed PMID: 29565380.

Microbiology

  1. Doron S, Melamed S, Ofir G, Leavitt A, Lopatina A, Keren M, Amitai G, Sorek R. Systematic discovery of antiphage defense systems in the microbial pangenome. Science. 2018 Mar 2;359(6379). pii: eaar4120. doi: 10.1126/science.aar4120. Epub 2018 Jan 25. PubMed PMID: 29371424.
  2. Pushkarev A, Inoue K, Larom S, Flores-Uribe J, Singh M, Konno M, Tomida S, Ito S, Nakamura R, Tsunoda SP, Philosof A, Sharon I, Yutin N, Koonin EV, Kandori H, Béjà O. A distinct abundant group of microbial rhodopsins discovered using functional metagenomics. Nature. 2018 Jun 20. doi: 10.1038/s41586-018-0225-9. [Epub ahead of print] PubMed PMID: 29925949.

Evolution

  1. Riddle MR, Aspiras AC, Gaudenz K, Peuß R, Sung JY, Martineau B, Peavey M, Box AC, Tabin JA, McGaugh S, Borowsky R, Tabin CJ, Rohner N. Insulin resistance in cavefish as an adaptation to a nutrient-limited environment. Nature. 2018 Mar 29;555(7698):647-651. doi: 10.1038/nature26136. Epub 2018 Mar 21. PubMed PMID: 29562229; PubMed Central PMCID: PMC5989729.

Neuroscience

  1. Weinhard L, di Bartolomei G, Bolasco G, Machado P, Schieber NL, Neniskyte U, Exiga M, Vadisiute A, Raggioli A, Schertel A, Schwab Y, Gross CT. Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction.  Nat Commun. 2018 Mar 26;9(1):1228. doi: 10.1038/s41467-018-03566-5. PubMed PMID: 29581545; PubMed Central PMCID: PMC5964317.
  2. Van Essen DC. Scaling of human brain size. Science. 2018 Jun 15;360(6394):1184-1185. doi: 10.1126/science.aat8948. PubMed PMID: 29903961.
  3. Reardon PK, Seidlitz J, Vandekar S, Liu S, Patel R, Park MTM, Alexander-Bloch A, Clasen LS, Blumenthal JD, Lalonde FM, Giedd JN, Gur RC, Gur RE, Lerch JP, Chakravarty MM, Satterthwaite TD, Shinohara RT, Raznahan A. Normative brain size variation and brain shape diversity in humans. Science. 2018 Jun 15;360(6394):1222-1227. doi: 10.1126/science.aar2578. Epub 2018 May 31. PubMed PMID: 29853553.

Genetics

  1.  Brainstorm Consortium et al., Analysis of shared heritability in common disorders of the brain. Science. 2018 Jun 22;360(6395). pii: eaap8757. doi: 10.1126/science.aap8757. PubMed PMID: 29930110.
  2. Wray NR, Wijmenga C, Sullivan PF, Yang J, Visscher PM. Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model. Cell. 2018 Jun 14;173(7):1573-1580. doi: 10.1016/j.cell.2018.05.051. Review. PubMed PMID: 29906445.

Cell Biology

  1. Ota S, Horisaki R, Kawamura Y, Ugawa M, Sato I, Hashimoto K, Kamesawa R, Setoyama K, Yamaguchi S, Fujiu K, Waki K, Noji H. Ghost cytometry. Science. 2018 Jun 15;360(6394):1246-1251. doi: 10.1126/science.aan0096. PubMed PMID: 29903975.

Signal Transduction

  1.  Capper MJ, Wacker D. How the ubiquitous GPCR receptor family selectively activates signalling pathways. Nature. 2018 Jun;558(7711):529-530. doi: 10.1038/d41586-018-05503-4. PubMed PMID: 29946098.

 

Genome-editing

  1. Niewoehner O, Garcia-Doval C, Rostøl JT, Berk C, Schwede F, Bigler L, Hall J, Marraffini LA, Jinek M. Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers. Nature. 2017 Aug 31;548(7669):543-548. doi:10.1038/nature23467. Epub 2017 Jul 19. PubMed PMID: 28722012.
  2. Johnson K, Bailey S. Microbiology: The case of the mysterious messenger. Nature. 2017 Aug 31;548(7669):527-528. doi: 10.1038/nature23532. Epub 2017 Aug 2. PubMed PMID: 28783729.
  3. Jain A, Zode G, Kasetti RB, Ran FA, Yan W, Sharma TP, Bugge K, Searby CC, Fingert JH, Zhang F, Clark AF, Sheffield VC. CRISPR-Cas9-based treatment of myocilin-associated glaucoma. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11199-11204. doi: 10.1073/pnas.1706193114. Epub 2017 Oct 2. PubMed PMID: 28973933; PubMed Central PMCID: PMC5651749.

Molecular biology

  1. García-López V, Chen F, Nilewski LG, Duret G, Aliyan A, Kolomeisky AB, Robinson JT, Wang G, Pal R, Tour JM. Molecular machines open cell membranes. Nature. 2017 Aug 30;548(7669):567-572. doi: 10.1038/nature23657. PubMed PMID: 28858304.

Development

  1. Liang J, Balachandra S, Ngo S, O’Brien LE. Feedback regulation of steady-state epithelial turnover and organ size. Nature. 2017 Aug 31;548(7669):588-591. doi: 10.1038/nature23678. Epub 2017 Aug 23. PubMed PMID: 28847000.
  2. Fernandes VM, Chen Z, Rossi AM, Zipfel J, Desplan C. Glia relay differentiation cues to coordinate neuronal development in Drosophila. Science. 2017 Sep 1;357(6354):886-891. doi: 10.1126/science.aan3174. PubMed PMID: 28860380.
  3. Boudreau-Pinsonneault C, Cayouette M. Cell lineage tracing in the retina: Could material transfer distort conclusions? Dev Dyn. 2018 Jan;247(1):10-17. doi: 10.1002/dvdy.24535. Epub 2017 Jul 13. PubMed PMID: 28643368.

Stem cells

  1. Kikuchi T, Morizane A, Doi D, Magotani H, Onoe H, Hayashi T, Mizuma H, Takara S, Takahashi R, Inoue H, Morita S, Yamamoto M, Okita K, Nakagawa M, Parmar M, Takahashi J. Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model. Nature. 2017 Aug 30;548(7669):592-596. doi: 10.1038/nature23664. PubMed PMID: 28858313.
  2. Hirota T, Ohta H, Powell BE, Mahadevaiah SK, Ojarikre OA, Saitou M, Turner JMA. Fertile offspring from sterile sex chromosome trisomic mice. Science. 2017 Sep 1;357(6354):932-935. doi: 10.1126/science.aam9046. Epub 2017 Aug 17. PubMed PMID: 28818972; PubMed Central PMCID: PMC5581950.
  3. Blanchard JW, Xie J, El-Mecharrafie N, Gross S, Lee S, Lerner RA, Baldwin KK. Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries. Nat Biotechnol. 2017 Oct;35(10):960-968. doi: 10.1038/nbt.3963. Epub 2017 Sep 11. PubMed PMID: 28892074.

Eye diseases

  1. Thorn RJ, Clift DE, Ojo O, Colwill RM, Creton R. The loss and recovery of vertebrate vision examined in microplates. PLoS One. 2017 Aug 17;12(8):e0183414. doi: 10.1371/journal.pone.0183414. eCollection 2017. PubMed PMID: 28817700; PubMed Central PMCID: PMC5560659.
  2. Jain A, Zode G, Kasetti RB, Ran FA, Yan W, Sharma TP, Bugge K, Searby CC, Fingert JH, Zhang F, Clark AF, Sheffield VC. CRISPR-Cas9-based treatment of myocilin-associated glaucoma. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11199-11204. doi: 10.1073/pnas.1706193114. Epub 2017 Oct 2. PubMed PMID: 28973933; PubMed Central PMCID: PMC5651749.

Vision

  1. Stowers JR, Hofbauer M, Bastien R, Griessner J, Higgins P, Farooqui S, Fischer RM, Nowikovsky K, Haubensak W, Couzin ID, Tessmar-Raible K, Straw AD. Virtual reality for freely moving animals. Nat Methods. 2017 Aug 21. doi: 10.1038/nmeth.4399. [Epub ahead of print] PubMed PMID: 28825703.

Education

  1. Silva HM. Intelligent design endangers education. Science. 2017 Sep 1;357(6354):880. doi: 10.1126/science.aao3245. PubMed PMID: 28860376.

Science Career

My second life as a teacher 



				

Neuroscience

  1. Robie AA, Hirokawa J, Edwards AW, Umayam LA, Lee A, Phillips ML, Card GM, Korff W, Rubin GM, Simpson JH, Reiser MB, Branson K. Mapping the Neural Substrates of Behavior. Cell. 2017 Jul 13;170(2):393-406.e28. doi: 10.1016/j.cell.2017.06.032. PubMed PMID: 28709004.
  2. Smith K. How to map the circuits that define us. Nature. 2017 Aug 9;548(7666):150-152. doi: 10.1038/548150a. PubMed PMID: 28796220.

Evolution

  1. Sousa AMM, Meyer KA, Santpere G, Gulden FO, Sestan N. Evolution of the Human Nervous System Function, Structure, and Development. Cell. 2017 Jul 13;170(2):226-247. doi: 10.1016/j.cell.2017.06.036. Review. PubMed PMID: 28708995.

Genetics

  1. New concerns raised over value of genome-wide disease studies

Cell biology

  1. Biology of single cells shines a light on collaboration. Nature. 2017 Jul 5;547(7661):5. doi: 10.1038/547005a. PubMed PMID: 28682351.

Genomics

  1. Nagano T, Lubling Y, Várnai C, Dudley C, Leung W, Baran Y, Mendelson Cohen N, Wingett S, Fraser P, Tanay A. Cell-cycle dynamics of chromosomal organization at single-cell resolution. Nature. 2017 Jul 5;547(7661):61-67. doi: 10.1038/nature23001. PubMed PMID: 28682332.

Molecular Biology

  1. Lin YL, Pasero P. Transcription-Replication Conflicts: Orientation Matters. Cell. 2017 Aug 10;170(4):603-604. doi: 10.1016/j.cell.2017.07.040. PubMed PMID: 28802036.

Genome editing

  1. Ma H, Marti-Gutierrez N, Park SW, Wu J, Lee Y, Suzuki K, Koski A, Ji D, Hayama T, Ahmed R, Darby H, Van Dyken C, Li Y, Kang E, Park AR, Kim D, Kim ST, Gong J, Gu Y, Xu X, Battaglia D, Krieg SA, Lee DM, Wu DH, Wolf DP, Heitner SB, Belmonte JCI, Amato P, Kim JS, Kaul S, Mitalipov S. Correction of a pathogenic gene mutation in human embryos. Nature. 2017 Aug 2. doi: 10.1038/nature23305. [Epub ahead of print] PubMed PMID: 28783728.

Genome editing

  1. Scheufele DA, Xenos MA, Howell EL, Rose KM, Brossard D, Hardy BW. U.S. attitudes on human genome editing. Science. 2017 Aug 11;357(6351):553-554. doi: 10.1126/science.aan3708. PubMed PMID: 28798120.
  2. Amitai G, Sorek R. Intracellular signaling in CRISPR-Cas defense. Science. 2017 Aug 11;357(6351):550-551. doi: 10.1126/science.aao2210. PubMed PMID: 28798118.
  3. Kazlauskiene M, Kostiuk G, Venclovas Č, Tamulaitis G, Siksnys V. A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems. Science. 2017 Aug 11;357(6351):605-609. doi: 10.1126/science.aao0100. Epub 2017 Jun 29. PubMed PMID: 28663439.

Eye

  1. Madl T. Patchy proteins form a perfect lens. Science. 2017 Aug 11;357(6351):546-547. doi: 10.1126/science.aao1456. PubMed PMID: 28798115.
  2. Cai J, Townsend JP, Dodson TC, Heiney PA, Sweeney AM. Eye patches: Protein assembly of index-gradient squid lenses. Science. 2017 Aug 11;357(6351):564-569. doi: 10.1126/science.aal2674. PubMed PMID: 28798124.

Funding

  1. Levitt M, Levitt JM. Future of fundamental discovery in US biomedical research. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6498-6503. doi: 10.1073/pnas.1609996114. Epub 2017 Jun 5. PubMed PMID: 28584129; PubMed Central PMCID: PMC5488913.

Yuk Fai Leung participated in the 2017 Developmental Biology Teaching Workshop (DBTW) from 27th June 2017 to 1st July 2017. This workshop was organized by Jennifer Fish from U Mass Lowell, Ian Woods from Ithaca College, and Eric Cole from St. Olaf College. It took place at the Darling Marine Center in Maine.

During this course, the participants studied many animal models for development including sea urchins, zebrafish, chicken, roundworm, flatworm and fruit flies. We focused on learning experiments that can be brought to the teaching lab to enrich student’s learning experience. Here are some pictures of the event:

The Developmental Biology Teaching Workshop, class of 2017.

Course leader Jennifer Fish

Course leader Ian Woods demonstrating zebrafish research.

Guest Instructor Eric Cole

The workshop took place at the beautiful Darling Marine Center.

Fai injected zebrafish embryos free hand with mouth pipetting.

Zebrafish with improper posterior development. Courtesy of 2017 DBTW.

An abnormal fruit fly made by the following transgenic line: dpp-GAL4; UAS-ey. Courtesy of 2017 DBTW.

Neurons in fruit fly larva labelled by green fluorescent protein. Courtesy of 2017 DBTW.

Sea Urchin Larva. Courtesy of 2017 DBTW.

Sea urchin larva 2. Courtesy of 2017 DBTW.

Roundworm. Nuclei labelled by a blue fluorescent dye. Courtesy of 2017 DBTW.

We finished the course with the final animal model–delicious lobsters from Maine!

Behaviour

  1. Palmér T, Ek F, Enqvist O, Olsson R, Åström K, Petersson P. Action sequencing in the spontaneous swimming behavior of zebrafish larvae – implications for drug development. Sci Rep. 2017 Jun 9;7(1):3191. doi: 10.1038/s41598-017-03144-7. PubMed PMID: 28600565; PubMed Central PMCID: PMC5466685.
  2. Vliet SM, Ho TC, Volz DC. Behavioral screening of the LOPAC(1280) library in zebrafish embryos. Toxicol Appl Pharmacol. 2017 Jun 13. pii: S0041-008X(17)30267-3. doi: 10.1016/j.taap.2017.06.011. [Epub ahead of print] PubMed PMID: 28623180.

Funding

  1. Kaiser J. NIH abandons grant cap, offers new help to younger scientists. Science. 2017 Jun 16;356(6343):1108. doi: 10.1126/science.356.6343.1108. PubMed PMID: 28619891.
  2. Wahls WP. NIH’s ineffective funding policies. Science. 2017 Jun 16;356(6343):1132-1133. doi: 10.1126/science.aan6504. PubMed PMID: 28619908.

Genetics

  1. Cassels L, Barde YA. Scaling pain threshold with microRNAs. Science. 2017 Jun 16;356(6343):1124-1125. doi: 10.1126/science.aan6784. PubMed PMID: 28619901.
  2. Peng C, Li L, Zhang MD, Bengtsson Gonzales C, Parisien M, Belfer I, Usoskin D, Abdo H, Furlan A, Häring M, Lallemend F, Harkany T, Diatchenko L, Hökfelt T, Hjerling-Leffler J, Ernfors P. miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. Science. 2017 Jun 16;356(6343):1168-1171. doi: 10.1126/science.aam7671. Epub 2017 Jun 1. PubMed PMID: 28572455.

Genomics

  1. Shekhar K, Lapan SW, Whitney IE, Tran NM, Macosko EZ, Kowalczyk M, Adiconis X, Levin JZ, Nemesh J, Goldman M, McCarroll SA, Cepko CL, Regev A, Sanes JR. Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics. Cell. 2016 Aug 25;166(5):1308-1323.e30. doi: 10.1016/j.cell.2016.07.054. PubMed PMID: 27565351; PubMed Central PMCID: PMC5003425.

Vision

  1. Sabbah S, Gemmer JA, Bhatia-Lin A, Manoff G, Castro G, Siegel JK, Jeffery N, Berson DM. A retinal code for motion along the gravitational and body axes. Nature. 2017 Jun 7. doi: 10.1038/nature22818. [Epub ahead of print] PubMed PMID: 28607486.
  2. Demb JB, Clark DA. Vision: These retinas are made for walkin’. Nature. 2017 Jun 7. doi: 10.1038/nature22505. [Epub ahead of print] PubMed PMID: 28607483

Genome editing

  1. Stella S, Alcón P, Montoya G. Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage. Nature. 2017 May 31. doi: 10.1038/nature22398. [Epub ahead of print] PubMed PMID: 28562584.
  2. Palermo G, Miao Y, Walker RC, Jinek M, McCammon JA. CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations. Proc Natl Acad Sci U S A. 2017 Jun 26. pii: 201707645. doi: 10.1073/pnas.1707645114. [Epub ahead of print] PubMed PMID: 28652374.
  3. Shipman SL, Nivala J, Macklis JD, Church GM. CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria. Nature. 2017 Jul 12. doi: 10.1038/nature23017. [Epub ahead of print] PubMed PMID: 28700573.

Stem cell

  1. Servick K. Stem cell approach for cataracts challenged. Science. 2017 Jun 30;356(6345):1318-1319. doi: 10.1126/science.356.6345.1318. PubMed PMID: 28663449.

Eye disease

  1. Servick K. Stem cell approach for cataracts challenged. Science. 2017 Jun 30;356(6345):1318-1319. doi: 10.1126/science.356.6345.1318. PubMed PMID: 28663449.

Ecology/Evolution

  1. Ceballos G, Ehrlich PR, Dirzo R. Biological annihilation via the ongoing sixth mass extinction signaled by vertebrate population losses and declines. Proc Natl Acad Sci U S A. 2017 Jul 10. pii: 201704949. doi: 10.1073/pnas.1704949114. [Epub ahead of print] PubMed PMID: 28696295.
  2. Castiglione GM, Hauser FE, Liao BS, Lujan NK, Van Nynatten A, Morrow JM, Schott RK, Bhattacharyya N, Dungan SZ, Chang BSW. Evolution of nonspectral rhodopsin function at high altitudes. Proc Natl Acad Sci U S A. 2017 Jun 22. pii: 201705765. doi: 10.1073/pnas.1705765114. [Epub ahead of print] PubMed PMID: 28642345.

Imaging

  1. Hildebrand DGC, Cicconet M, Torres RM, Choi W, Quan TM, Moon J, Wetzel AW, Scott Champion A, Graham BJ, Randlett O, Plummer GS, Portugues R, Bianco IH, Saalfeld S, Baden AD, Lillaney K, Burns R, Vogelstein JT, Schier AF, Lee WA, Jeong WK, Lichtman JW, Engert F. Whole-brain serial-section electron microscopy in larval zebrafish. Nature. 2017 May 18;545(7654):345-349. doi: 10.1038/nature22356. Epub 2017 May 10. PubMed PMID: 28489821.

Neuroscience

  1. Ciabatti E, González-Rueda A, Mariotti L, Morgese F, Tripodi M. Life-Long Genetic and Functional Access to Neural Circuits Using Self-Inactivating Rabies Virus. Cell. 2017 Jul 1. pii: S0092-8674(17)30697-9. doi: 10.1016/j.cell.2017.06.014. [Epub ahead of print] PubMed PMID: 28689641.