Skip to main content


Hanley Distinguished Professor of Biological Sciences;
National Academy of Science


Personal Site: Link

The central interest of my laboratory is the determination of the three-dimensional, atomic resolution structure of viruses. However, it is not only the structure of the mature infectious virus that interests us, but all the structures that are involved in the assembly of the virus in a host cell, the interaction of viruses with host cells that initiates entry into the cell and infection, as well as the structures of viruses complexed with neutralizing antibodies or antiviral agents (potential drugs). In short, we are investigating the way viruses interact with their environment.

Our tools are X-ray crystallography for high resolution studies and electron microscopy for lower resolution studies of transient virus complexes, as well as all the tools of molecular biology. The viruses we are currently studying include a variety of small RNA animal viruses, such as common cold viruses, polioviruses and coxsackieviruses. We are also looking at more complicated, lipid membrane enveloped RNA viruses, such as dengue virus and alphaviruses. We have long been interested in the small DNA parvoviruses. Finally, we have been studying how viruses package their nucleic acid genomes in the analyses of a variety of bacterial viruses.


Ph.D., Glasgow (Scotland), 1956


  • Member of the Royal Society of London
  • Member of the National Academy of Sciences
  • Recipient of a third National Institutes of Health MERIT Award, 2006
  • Elected Fellow, American Academy of Microbiology, 2007

Other Activities

Editorial Boards

  • Current Opinion in Structural Biology
  • Structure with Folding and Design
  • Virology

Grant Review/Study Section

  • NIH
  • NSF
  • NIH Virology Study Section, Washington, DC, June 16, 2004.
  • Austrian Science Foundation
  • European Science Foundation
  • German-Israel Foundation for Science Research and Development

Professional Faculty Research

(Molecular biology; biophysics) Structure of picornaviruses (rhinoviruses, Mengo virus, coxsackievirus, poliovirus), parvoviruses, alphaviruses and bacteriophages, fX174, f29, T4; molecular evolution.

Purdue University Biological Sciences, 915 W. State Street, West Lafayette, IN 47907

Main Office: (765) 494-4408   Business Office: (765) 494-4764  Contact Us

© 2015 Purdue University | An equal access/equal opportunity university | Copyright Complaints

Trouble with this page? Disability-related accessibility issue? Please contact the College of Science Webmaster.

Maintained by Science IT