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WEN JIANG

WEN JIANG

Professor
HOCK 131
Phone: 765-496-8436

Personal Site: Link

Electron cryomicroscopy (cryo-EM) is an emerging technique for solving structures of large macromolecular machines. It does not require crystalline order for the studied specimens. This unique capability makes cryo-EM extremely valuable in imaging and solving the structures and the dynamics of macromolecular machines.

We use cryo-EM to study the structures and functions of viruses, protein complexes, and nano-particles. We are also interested in the development of cryo-EM techniques including stablization of protein conformations, affinity grids, TEM alignment, data collection automation, and image processing/3D reconstruction algorithms. The technical advances will help push cryo-EM towards near atomic resolution (2-4 Angstrom) single particle 3-D reconstructions and tomographic 3-D reconstructions, and to ultimately transform the current laborious cryo-EM technique with steep learning curve into an easily accessible and high throughput tool for any biologist.

Education

Ph.D. in Cryo-EM and Structural Biology, Baylor College of Medicine, 2001
M.S. in Biophysics, Institute of Biophysics, Chinese Academy of Sciences, 1995
B.S. in Physics, Peking University, 1992

Professional Faculty Research

(Cryo-EM, structural biology, biophysics, and computational biology) Structures of viruses, protein complexes, nano-particles; Structure based drug discovery; Development of cryo-EM methods including stablization of protein conformations, affinity grids, TEM alignment, data collection automation, and image processing/3D reconstruction algorithms 

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