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HOCK 131
Phone: 765-496-8436

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Electron cryomicroscopy (cryo-EM) is an emerging technique for solving structures of large macromolecular machines. It does not require crystalline order for the studied specimens. This unique capability makes cryo-EM extremely valuable in imaging and solving the structures and the dynamics of macromolecular machines.

We use cryo-EM to study the assembly, maturation, and infection mechanism of viruses including dsDNA tailed bacteriophages and noroviruses. We are also interested in the development of cryo-EM techniques including image processing algorithms, high performance computing, data collection automation, and sample preparation. The technical advances will help push cryo-EM towards near atomic resolution (2-4 Angstrom) single particle 3-D reconstructions and tomographic 3-D reconstructions, and to ultimately transform the current laborious cryo-EM technique with steep learning curve into an easily accessible and high throughput tool at the disposal of any biologist.


Ph.D., Baylor College of Medicine, 2001
M.S., Chinese Academy of Sciences, 1995
B.S., Peking University, 1992

Professional Faculty Research

(single particle cryo-EM, electron crystallography, electron tomography, biophysics) Structure of viruses, macromolecular complexes, and nano-particles; technique developments in cryo-EM for structural determination of macromolecular machines at atomic resolutions; image processing and 3-D reconstruction; computational biology

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