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Biology Research News


Pancreatic cancer 'time machine’ exposes plot twist in cell growth and invasion

Pancreatic cancer 'time machine’ exposes plot twist in cell growth and invasion
2020-02-13

Invasive cancer sprouts from an artificial pancreatic duct engineered by Purdue University researchers. The cell bodies are stained magenta and the nuclei are stained blue. (Purdue University image/Stephanie Venis, Hye-ran Moon and Bumsoo Han)

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The road not taken: host infection status influences parasite host-choice

The road not taken: host infection status influences parasite host-choice
2020-01-15

Two roads diverged in a green pond And some parasites take the road less parasitized

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HIV chromatin is a preferred target for drugs that bind in the DNA minor groove

HIV chromatin is a preferred target for drugs that bind in the DNA minor groove
2020-01-15

The major challenge in current HIV research is the development of methods to eliminate the replication competent HIV provirus that has integrated as a double stranded DNA molecule within the host cell chromatin. This viral reservoir is activated upon session of antiviral drug therapy giving rise to new rounds of replication and the resumption of active infection. CRISPR/Cas9-based HIV-1/AIDS therapeutic strategies have been suggested as the best way to inactivate the HIV sequences in the genome but recent studies have shown that nucleosomes can strongly inhibit CRISPR-Cas9 targeting and cleavage efficiency. Our recent studies provide a way to circumvent this limitation.

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Luo Lab research published in the EMBO Journal

Luo Lab research published in the EMBO Journal
2020-01-07

Ubiquitination involved in the attachment of the 76-residue ubiquitin protein to target proteins play essential roles in many cellular processes, particularly immunity.

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Could Anthrax Help Fight Bladder Cancer?

Could Anthrax Help Fight Bladder Cancer?
2019-11-13

Anthrax may soon help more people win the fight against bladder cancer, which the U.S. Centers for Disease Control and Prevention says strikes about 72,000 Americans each year and kills about 16,000, and is one of the most expensive cancers to treat.

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Risky business: Frogs’ mating calls also attract predators

Risky business: Frogs’ mating calls also attract predators
2019-11-12

Frogs have been struggling a bit in recent years. Their populations around the world have been declining for decades, and the reasons for their loss come from many fronts. In the túngara frog — a tiny native of Middle, Central and South America — disease, predation and communication are intricately intertwined. Parasites are transmitted by midges, which find their way to frogs by “intercepting” their mating calls.

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Purdue virus expert David Sanders comments on explosion at former Russian Bioweapons Lab.

Purdue virus expert David Sanders comments on explosion at former Russian Bioweapons Lab.
2019-09-20

An interview with Professor David Sanders about the explosion at the Novosibirsk Vector virus laboratory on the BBC, The World Tonight.

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Conservation and disease in tropical amphibians

Conservation and disease in tropical amphibians
2019-08-30

The fungal pathogen, Batrachochytrium dendrobatidis (Bd) has been associated with severe declines and extinctions of amphibians around the world.

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Contemporary Approaches to Keeping Up With The Scientific Literature

Contemporary Approaches to Keeping Up With The Scientific Literature
2019-08-30

My article, an invited contribution, on contemporary approaches to keeping up with the literature, addresses teaching and research, review articles, social media, and critique of the scientific literature.

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A novel role for CDK2 as a new approach for treating neutrophilic inflammation

A novel role for CDK2 as a new approach for treating neutrophilic inflammation
2019-08-22

Neutrophils are the first cells recruited to an immune stimulus stemming from infection.

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Collaborative effort by the Suter, Mattoo, and Huang labs provide new insights into filopodia formation

Collaborative effort by the Suter, Mattoo, and Huang labs provide new insights into filopodia formation
2019-08-20

The research was a collaborative effort by the Suter, Mattoo, and Huang labs at Purdue and was funded by multiple grants.

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Discovery provides path to pathogen-targeted antibiotics

Discovery provides path to pathogen-targeted antibiotics
2019-08-15

"Take with food" is a common warning for people using antibiotics, but a discovery announced this week in the scientific journal Nature may create a path to more targeted drugs.

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A natural product chemical probe inhibits cardiac hypertrophy mediated by nuclear GPCR kinase 5

A natural product chemical probe inhibits cardiac hypertrophy mediated by nuclear GPCR kinase 5
2019-07-26

Structure of malbrancheamide in complex with Ca2+·calmodulin

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New Avenue for Parkinson’s Disease Research

New Avenue for Parkinson’s Disease Research
2019-07-02

Mattoo lab discovers new link between neurodegeneration and Fic proteins

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Dr. Leifu Chang's Group published in Cell Host & Microbe

Dr. Leifu Chang's Group published in Cell Host & Microbe
2019-06-19

Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins

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These molecules could trap viruses inside a cell

These molecules could trap viruses inside a cell
2019-04-17

Role of heparan sulfate in entry and exit of Ross River virus glycoprotein-pseudotyped retroviral vectors

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New quantum material could warn of neurological disease

New quantum material could warn of neurological disease
2019-04-17

“This quantum material is about nine times more sensitive to dopamine than methods that we use currently in animal models,” said Alexander Chubykin

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An invasive species is most successful with high resources and infectious disease

An invasive species is most successful with high resources and infectious disease
2019-04-17

An adult Daphnia lumholtzi. This species has invaded many lakes throughout the United States.

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Mattoo lab develops a new cell biology tool called CryoAPEX

Mattoo lab develops a new cell biology tool called CryoAPEX
2019-04-12

New electron microscopy technique limits membrane destruction

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Making sense of large-scale behavioural data for eye-drug discovery

Making sense of large-scale behavioural data for eye-drug discovery
2019-03-12

Making sense of large-scale behavioural data for eye-drug discovery

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