Posts tagged ‘neuroscience’

Eye diseases

  1. Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y. Lens regeneration using endogenous stem cells with gain of visual function. Nature. 2016 Mar 9. doi: 10.1038/nature17181. [Epub ahead of print] PubMed PMID: 26958831. News release: Stem Cells Regenerate Human Lens After Cataract Surgery, Restoring Vision
  2. Hayashi R, Ishikawa Y, Sasamoto Y, Katori R, Nomura N, Ichikawa T, Araki S, Soma T, Kawasaki S, Sekiguchi K, Quantock AJ, Tsujikawa M, Nishida K. Co-ordinated ocular development from human iPS cells and recovery of corneal function. Nature. 2016 Mar 9. doi: 10.1038/nature17000. [Epub ahead of print] PubMed PMID: 26958835.

Stem cells

  1. Sridhar A, Ohlemacher SK, Langer KB, Meyer JS. Robust Differentiation of mRNA-Reprogrammed Human Induced Pluripotent Stem Cells Toward a Retinal Lineage. Stem Cells Transl Med. 2016 Mar 1. pii: sctm.2015-0093. [Epub ahead of print] PubMed PMID: 26933039.
  2. Sagi I, Chia G, Golan-Lev T, Peretz M, Weissbein U, Sui L, Sauer MV, Yanuka O, Egli D, Benvenisty N. Derivation and differentiation of haploid human embryonic stem cells. Nature. 2016 Mar 16. doi: 10.1038/nature17408. [Epub ahead of print] PubMed PMID: 26982723.

Development

  1. Pueschel R, Coraggio F, Meister P. From single genes to entire genomes: the search for a function of nuclear organization. Development. 2016 Mar 15;143(6):910-23. doi: 10.1242/dev.129007. Review. PubMed PMID: 26980791.
  2. Salomon DR. A CRISPR Way to Block PERVs – Engineering Organs for Transplantation. N Engl J Med. 2016 Mar 17;374(11):1089-1091. PubMed PMID: 26981939.

Neuroscience

  1. Mullins C, Fishell G, Tsien RW. Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops. Neuron. 2016 Mar 16;89(6):1131-56. doi: 10.1016/j.neuron.2016.02.017. Review. PubMed PMID: 26985722.
  2. Hazen JL, Faust GG, Rodriguez AR, Ferguson WC, Shumilina S, Clark RA, Boland MJ, Martin G, Chubukov P, Tsunemoto RK, Torkamani A, Kupriyanov S, Hall IM, Baldwin KK. The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning. Neuron. 2016 Mar 16;89(6):1223-36. doi: 10.1016/j.neuron.2016.02.004. Epub 2016 Mar 3. PubMed PMID: 26948891; PubMed Central PMCID: PMC4795965.

Mathematics

  1. Castelvecchi D. Fermat’s last theorem earns Andrew Wiles the Abel Prize. Nature. 2016 Mar 17;531(7594):287. doi: 10.1038/nature.2016.19552. PubMed PMID: 26983518.

Genetics

  1. Gage SH, Davey Smith G, Ware JJ, Flint J, Munafò MR. G = E: What GWAS Can Tell Us about the Environment. PLoS Genet. 2016 Feb 11;12(2):e1005765. doi: 10.1371/journal.pgen.1005765. eCollection 2016 Feb. PubMed PMID: 26866486.
  2. Murray A. Salvador Luria and Max Delbrück on Random Mutation and Fluctuation Tests. Genetics. 2016 Feb;202(2):367-8. doi: 10.1534/genetics.115.186163. PubMed PMID: 26869479.

Neuroscience

  1. A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States Zebrafish Reel in Phenotypic Suppressors of Autism Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2
  2. Carr F. Reward: A separate sweet circuit. Nat Rev Neurosci. 2016 Feb 11. doi: 10.1038/nrn.2016.19. [Epub ahead of print] PubMed PMID: 26865014.

Evolution

  1. Fox D. What sparked the Cambrian explosion? Nature. 2016 Feb 18;530(7590):268-70. doi: 10.1038/530268a. PubMed PMID: 26887475.
  2. McGowan KA, Barsh GS. How the zebrafish got its stripes. Elife. 2016 Feb 15;5. pii: e14239. doi: 10.7554/eLife.14239. PubMed PMID: 26880558.

Scientific publication

  1. Callaway E, Powell K. Biologists urged to hug a preprint. Nature. 2016 Feb 18;530(7590):265. doi: 10.1038/530265a. PubMed PMID: 26887471.
  2. Powell K. Does it take too long to publish research? Nature. 2016 Feb 11;530(7589):148-51. doi: 10.1038/530148a. PubMed PMID: 26863966.

Development

  1. Webb AB, Lengyel IM, Jörg DJ, Valentin G, Jülicher F, Morelli LG, Oates AC. Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock. Elife. 2016 Feb 16;5. pii: e08438. doi: 10.7554/eLife.08438. [Epub ahead of print] PubMed PMID: 26880542.

Genome editing

  1. Nyerges Á, Csörgő B, Nagy I, Bálint B, Bihari P, Lázár V, Apjok G, Umenhoffer K, Bogos B, Pósfai G, Pál C. A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species. Proc Natl Acad Sci U S A. 2016 Feb 16. pii: 201520040. [Epub ahead of print] PubMed PMID: 26884157.
  2. Wong AS, Choi GC, Cui CH, Pregernig G, Milani P, Adam M, Perli SD, Kazer SW, Gaillard A, Hermann M, Shalek AK, Fraenkel E, Lu TK. Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM. Proc Natl Acad Sci U S A. 2016 Feb 10. pii: 201517883. [Epub ahead of print] PubMed PMID: 26864203.
  3. Hirano H, Gootenberg JS, Horii T, Abudayyeh OO, Kimura M, Hsu PD, Nakane T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O. Structure and Engineering of Francisella novicida Cas9. Cell. 2016 Feb 10. pii: S0092-8674(16)30053-8. doi: 10.1016/j.cell.2016.01.039. [Epub ahead of print] PubMed PMID: 26875867.
  4. Orkin SH. Recent advances in globin research using genome-wide association studies and gene editing. Ann N Y Acad Sci. 2016 Feb 11. doi: 10.1111/nyas.13001. [Epub ahead of print] PubMed PMID: 26866328.

				

Scientific publishing

  1. Gibney E. Open journals that piggyback on arXiv gather momentum. Nature. 2016 Feb 4;530(7588):117-8. PubMed PMID: 26854297.

Genome editing

  1. Wu B, Luo L, Gao XJ. Cas9-triggered chain ablation of cas9 as a gene drive brake. Nat Biotechnol. 2016 Feb 5;34(2):137-8. doi: 10.1038/nbt.3444. PubMed PMID: 26849513.
  2. Alphey L. Can CRISPR-Cas9 gene drives curb malaria? Nat Biotechnol. 2016 Feb 5;34(2):149-50. doi: 10.1038/nbt.3473. PubMed PMID: 26849518.
  3. Rajagopal N, Srinivasan S, Kooshesh K, Guo Y, Edwards MD, Banerjee B, Syed T, Emons BJ, Gifford DK, Sherwood RI. High-throughput mapping of regulatory DNA. Nat Biotechnol. 2016 Feb;34(2):167-74. doi: 10.1038/nbt.3468. Epub 2016 Jan 25. PubMed PMID: 26807528.
  4. Korkmaz G, Lopes R, Ugalde AP, Nevedomskaya E, Han R, Myacheva K, Zwart W, Elkon R, Agami R. Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9. Nat Biotechnol. 2016 Feb;34(2):192-8. doi: 10.1038/nbt.3450. Epub 2016 Jan 11. PubMed PMID: 26751173.
  5. Zhou Y, Wei W. Mapping regulatory elements. Nat Biotechnol. 2016 Feb 5;34(2):151-2. doi: 10.1038/nbt.3477. PubMed PMID: 26849519.
  6. Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9. Nat Biotechnol. 2016 Feb;34(2):184-91. doi: 10.1038/nbt.3437. Epub 2016 Jan 18. PubMed PMID: 26780180; PubMed Central PMCID: PMC4744125.
  7. Farasat I, Salis HM. A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation. PLoS Comput Biol. 2016 Jan 29;12(1):e1004724. doi: 10.1371/journal.pcbi.1004724. eCollection 2016 Jan. PubMed PMID: 26824432; PubMed Central PMCID: PMC4732943.

Neuroscience

  1. Fuzik J, Zeisel A, Máté Z, Calvigioni D, Yanagawa Y, Szabó G, Linnarsson S, Harkany T. Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes. Nat Biotechnol. 2016 Feb;34(2):175-83. doi: 10.1038/nbt.3443. Epub 2015 Dec 21. PubMed PMID: 26689544.
  2. Cadwell CR, Palasantza A, Jiang X, Berens P, Deng Q, Yilmaz M, Reimer J, Shen S, Bethge M, Tolias KF, Sandberg R, Tolias AS. Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq. Nat Biotechnol. 2016 Feb;34(2):199-203. doi: 10.1038/nbt.3445. Epub 2015 Dec 21. PubMed PMID: 26689543.

Disease

  1. Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, Mraz J, Kolenc M, Resman Rus K, Vesnaver Vipotnik T, Fabjan Vodušek V, Vizjak A, Pižem J, Petrovec M, Avšič Županc T. Zika Virus Associated with Microcephaly. N Engl J Med. 2016 Feb 10. [Epub ahead of print] PubMed PMID: 26862926.

ESLI

  1. Baker M. Biotech giant publishes failures to confirm high-profile science. Nature. 2016 Feb 11;530(7589):141. doi: 10.1038/nature.2016.19269. PubMed PMID: 26863961.

Stem cells

  1. Chakradhar S. An eye to the future: Researchers debate best path for stem cell-derived therapies. Nat Med. 2016 Feb 4;22(2):116-9. doi: 10.1038/nm0216-116. PubMed PMID: 26845400.
  2. Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A. Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell. 2016 Feb 11;164(4):668-80. doi: 10.1016/j.cell.2015.12.033. PubMed PMID: 26871632.

Systems Biology

  1. Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 Feb 11;164(4):805-17. doi: 10.1016/j.cell.2016.01.029. PubMed PMID: 26871637.
  2. Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11;164(4):780-91. doi: 10.1016/j.cell.2016.01.012. Epub 2016 Jan 28. PubMed PMID: 26830878; PubMed Central PMCID: PMC4752866.
  3. Tsiairis CD, Aulehla A. Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns. Cell. 2016 Feb 11;164(4):656-67. doi: 10.1016/j.cell.2016.01.028. PubMed PMID: 26871631.
  4. Sylwestrak EL, Rajasethupathy P, Wright MA, Jaffe A, Deisseroth K. Multiplexed Intact-Tissue Transcriptional Analysis at Cellular Resolution. Cell. 2016 Feb 11;164(4):792-804. doi: 10.1016/j.cell.2016.01.038. PubMed PMID: 26871636.

Development

  1. Tsiairis CD, Aulehla A. Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns. Cell. 2016 Feb 11;164(4):656-67. doi: 10.1016/j.cell.2016.01.028. PubMed PMID: 26871631.

Genomics

  1. Shen SQ, Myers CA, Hughes AE, Byrne LC, Flannery JG, Corbo JC. Massively parallel cis-regulatory analysis in the mammalian central nervous system. Genome Res. 2016 Feb;26(2):238-55. doi: 10.1101/gr.193789.115. Epub 2015 Nov 17. PubMed PMID: 26576614.
  2. Quick J, et al., . Real-time, portable genome sequencing for Ebola surveillance. Nature. 2016 Feb 3. doi: 10.1038/nature16996. [Epub ahead of print] PubMed PMID: 26840485.

Neuroscience

  1. Ishiko N, Huberman AD. Life goes by: a visual circuit signals perceptual-motor mismatch. Nat Neurosci. 2016 Jan 27;19(2):177-9. doi: 10.1038/nn.4233. PubMed PMID: 26814584.
  2. Tasic B, Menon V, Nguyen TN, Kim TK, Jarsky T, Yao Z, Levi B, Gray LT, Sorensen SA, Dolbeare T, Bertagnolli D, Goldy J, Shapovalova N, Parry S, Lee C, Smith K, Bernard A, Madisen L, Sunkin SM, Hawrylycz M, Koch C, Zeng H. Adult mouse cortical cell taxonomy revealed by single cell transcriptomics. Nat Neurosci. 2016 Feb;19(2):335-46. doi: 10.1038/nn.4216. Epub 2016 Jan 4. PubMed PMID: 26727548.
  3. Chen HH, Arlotta P. Seq-ing the cortex one neuron at a time. Nat Neurosci. 2016 Jan 27;19(2):179-81. doi: 10.1038/nn.4230. PubMed PMID: 26814585.
  4. Johnson MR, Shkura K, Langley SR, Delahaye-Duriez A, Srivastava P, Hill WD, Rackham OJ, Davies G, Harris SE, Moreno-Moral A, Rotival M, Speed D, Petrovski S, Katz A, Hayward C, Porteous DJ, Smith BH, Padmanabhan S, Hocking LJ, Starr JM, Liewald DC, Visconti A, Falchi M, Bottolo L, Rossetti T, Danis B, Mazzuferi M, Foerch P, Grote A, Helmstaedter C, Becker AJ, Kaminski RM, Deary IJ, Petretto E. Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease. Nat Neurosci. 2016 Feb;19(2):223-32. doi: 10.1038/nn.4205. Epub 2015 Dec 21. PubMed PMID: 26691832.
  5. Yoshimatsu T, D’Orazi FD, Gamlin CR, Suzuki SC, Suli A, Kimelman D, Raible DW, Wong RO. Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo. Nat Commun. 2016 Feb 3;7:10590. doi: 10.1038/ncomms10590. PubMed PMID: 26838932.
  6. Hoffman EJ, Turner KJ, Fernandez JM, Cifuentes D, Ghosh M, Ijaz S, Jain RA, Kubo F, Bill BR, Baier H, Granato M, Barresi MJ, Wilson SW, Rihel J, State MW, Giraldez AJ. Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2. Neuron. 2016 Jan 27. pii: S0896-6273(15)01167-8. doi: 10.1016/j.neuron.2015.12.039. [Epub ahead of print] PubMed PMID: 26833134.

Development

  1. Rister J, Razzaq A, Boodram P, Desai N, Tsanis C, Chen H, Jukam D, Desplan C. Single-base pair differences in a shared motif determine differential Rhodopsin expression. Science. 2015 Dec 4;350(6265):1258-61. doi: 10.1126/science.aab3417. PubMed PMID: 26785491.

Genome editing

  1. Farasat I, Salis HM. A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation. PLoS Comput Biol. 2016 Jan 29;12(1):e1004724. doi: 10.1371/journal.pcbi.1004724. eCollection 2016 Jan. PubMed PMID: 26824432.
  2.  Song J, Yang D, Xu J, Zhu T, Chen YE, Zhang J. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016 Jan 28;7:10548. doi: 10.1038/ncomms10548. PubMed PMID: 26817820.
  3. Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA. Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage. Science. 2016 Jan 14. pii: aad8282. [Epub ahead of print] PubMed PMID: 26841432.
  4.  Jusiak B, Cleto S, Perez-Piñera P, Lu TK. Engineering Synthetic Gene Circuits in Living Cells with CRISPR Technology. Trends Biotechnol. 2016 Jan 22. pii: S0167-7799(15)00274-7. doi: 10.1016/j.tibtech.2015.12.014. [Epub ahead of print] Review. PubMed PMID: 26809780.

Molecular Biology

  1. Weingarten-Gabbay S, Elias-Kirma S, Nir R, Gritsenko AA, Stern-Ginossar N, Yakhini Z, Weinberger A, Segal E. Comparative genetics. Systematic discovery of cap-independent translation sequences in human and viral genomes. Science. 2016 Jan 15;351(6270). pii: aad4939. doi: 10.1126/science.aad4939. Epub 2016 Jan 14. PubMed PMID: 26816383.
  2. Bernecky C, Herzog F, Baumeister W, Plitzko JM, Cramer P. Structure of transcribing mammalian RNA polymerase II. Nature. 2016 Jan 20. doi: 10.1038/nature16482. [Epub ahead of print] PubMed PMID: 26789250.

Systems Biology

  1. Bartocci E, Lió P. Computational Modeling, Formal Analysis, and Tools for Systems Biology. PLoS Comput Biol. 2016 Jan 21;12(1):e1004591. doi: 10.1371/journal.pcbi.1004591. eCollection 2016 Jan. Review. PubMed PMID: 26795950.

Neuroscience

  1. Oliveira RF, Simões JM, Teles MC, Oliveira CR, Becker JD, Lopes JS. Assessment of fight outcome is needed to activate socially driven transcriptional changes in the zebrafish brain. Proc Natl Acad Sci U S A. 2016 Jan 19. pii: 201514292. [Epub ahead of print] PubMed PMID: 26787876.
  2. Randlett O, Wee CL, Naumann EA, Nnaemeka O, Schoppik D, Fitzgerald JE, Portugues R, Lacoste AM, Riegler C, Engert F, Schier AF. Whole-brain activity mapping onto a zebrafish brain atlas. Nat Methods. 2015 Nov;12(11):1039-1046. Epub 2015 Sep 14. PubMed PMID: 26778924; PubMed Central PMCID: PMC4710481.
  3. Liu Z, Li X, Zhang JT, Cai YJ, Cheng TL, Cheng C, Wang Y, Zhang CC, Nie YH, Chen ZF, Bian WJ, Zhang L, Xiao J, Lu B, Zhang YF, Zhang XD, Sang X, Wu JJ, Xu X, Xiong ZQ, Zhang F, Yu X, Gong N, Zhou WH, Sun Q, Qiu Z. Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. Nature. 2016 Jan 25. doi: 10.1038/nature16533. [Epub ahead of print] PubMed PMID: 26808898.
  4. Dunn TW, Gebhardt C, Naumann EA, Riegler C, Ahrens MB, Engert F, Del Bene F. Neural Circuits Underlying Visually Evoked Escapes in Larval Zebrafish. Neuron. 2016 Jan 19. pii: S0896-6273(15)01123-X. doi: 10.1016/j.neuron.2015.12.021. [Epub ahead of print] PubMed PMID: 26804997.

Genome editing

  1. Where genome editing is needed. Nat Genet. 2016 Jan 27;48(2):103. doi: 10.1038/ng.3505. PubMed PMID: 26813758.
  2. Huang S, Weigel D, Beachy RN, Li J. A proposed regulatory framework for genome-edited crops. Nat Genet. 2016 Jan 27;48(2):109-11. doi: 10.1038/ng.3484. PubMed PMID: 26813761.
  3. Kleinstiver BP, Pattanayak V, Prew MS, Tsai SQ, Nguyen NT, Zheng Z, Joung JK. High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature. 2016 Jan 6. doi: 10.1038/nature16526. [Epub ahead of print] PubMed PMID: 26735016.
  4.  Slaymaker IM, Gao L, Zetsche B, Scott DA, Yan WX, Zhang F. Rationally engineered Cas9 nucleases with improved specificity. Science. 2016 Jan 1;351(6268):84-8. doi: 10.1126/science.aad5227. Epub 2015 Dec 1. PubMed PMID: 26628643; PubMed Central PMCID: PMC4714946.
  5. Urnov F. Genome editing: The domestication of Cas9. Nature. 2016 Jan 28;529(7587):468-9. doi: 10.1038/529468a. PubMed PMID: 26819037.

Eye diseases

  1. Fritsche LG, et al., A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet. 2015 Dec 21. doi: 10.1038/ng.3448. [Epub ahead of print] PubMed PMID: 26691988.
  2. Saksens NT, Krebs MP, Schoenmaker-Koller FE, Hicks W, Yu M, Shi L, Rowe L, Collin GB, Charette JR, Letteboer SJ, Neveling K, van Moorsel TW, Abu-Ltaif S, De Baere E, Walraedt S, Banfi S, Simonelli F, Cremers FP, Boon CJ, Roepman R, Leroy BP, Peachey NS, Hoyng CB, Nishina PM, den Hollander AI. Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity. Nat Genet. 2015 Dec 21. doi: 10.1038/ng.3474. [Epub ahead of print] PubMed PMID: 26691986.
  3. Bailey JN, et al., Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nat Genet. 2016 Jan 11. doi: 10.1038/ng.3482. [Epub ahead of print] PubMed PMID: 26752265.

Development

  1. Rajagopal J, Stanger BZ. Plasticity in the Adult: How Should the Waddington Diagram Be Applied to Regenerating Tissues? Dev Cell. 2016 Jan 25;36(2):133-137. doi: 10.1016/j.devcel.2015.12.021. Review. PubMed PMID: 26812013.
  2. Stegmaier J, Amat F, Lemon WC, McDole K, Wan Y, Teodoro G, Mikut R, Keller PJ. Real-Time Three-Dimensional Cell Segmentation in Large-Scale Microscopy Data of Developing Embryos. Dev Cell. 2016 Jan 25;36(2):225-240. doi: 10.1016/j.devcel.2015.12.028. PubMed PMID: 26812020.
  3. Yamauchi Y, Riel JM, Ruthig VA, Ortega EA, Mitchell MJ, Ward MA. Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction. Science. 2016 Jan 29;351(6272):514-6. doi: 10.1126/science.aad1795. PubMed PMID: 26823431.
  4. Quan XJ, Yuan L, Tiberi L, Claeys A, De Geest N, Yan J, van der Kant R, Xie WR, Klisch TJ, Shymkowitz J, Rousseau F, Bollen M, Beullens M, Zoghbi HY, Vanderhaeghen P, Hassan BA. Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis. Cell. 2016 Jan 28;164(3):460-75. doi: 10.1016/j.cell.2015.12.048. PubMed PMID: 26824657.

Disease

  1. Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science. 2016 Jan 29;351(6272):aad2197. doi: 10.1126/science.aad2197. Epub 2016 Jan 28. PubMed PMID: 26823433.
 

Development

  1. Eom DS, Bain EJ, Patterson LB, Grout ME, Parichy DM. Long-distance communication by specialized cellular projections during pigment pattern development and evolution. Elife. 2015 Dec 23;4. pii: e12401. doi: 10.7554/eLife.12401. [Epub ahead of print] PubMed PMID: 26701906.

Stem cells

  1. Shirai H, Mandai M, Matsushita K, Kuwahara A, Yonemura S, Nakano T, Assawachananont J, Kimura T, Saito K, Terasaki H, Eiraku M, Sasai Y, Takahashi M. Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration. Proc Natl Acad Sci U S A. 2015 Dec 22. pii: 201512590. [Epub ahead of print] PubMed PMID: 26699487.

Zebrafish

  1. Stapel LC, Lombardot B, Broaddus C, Kainmueller D, Jug F, Myers EW, Vastenhouw NL. Automated detection and quantification of single RNAs at cellular resolution in zebrafish embryos. Development. 2015 Dec 23. pii: dev.128918. [Epub ahead of print] PubMed PMID: 26700682.

Genome editing

  1. Shmakov S, Abudayyeh OO, Makarova KS, Wolf YI, Gootenberg JS, Semenova E, Minakhin L, Joung J, Konermann S, Severinov K, Zhang F, Koonin EV. Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems. Mol Cell. 2015 Nov 5;60(3):385-97. doi: 10.1016/j.molcel.2015.10.008. Epub 2015 Oct 22. PubMed PMID: 26593719; PubMed Central PMCID: PMC4660269.
  2. Bolukbasi MF, Gupta A, Wolfe SA. Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery. Nat Methods. 2015 Dec 30;13(1):41-50. doi: 10.1038/nmeth.3684. PubMed PMID: 26716561.
  3. Kleinstiver BP, Pattanayak V, Prew MS, Tsai SQ, Nguyen NT, Zheng Z, Keith Joung J. High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature. 2016 Jan 6. doi: 10.1038/nature16526. [Epub ahead of print] PubMed PMID: 26735016.
  4. Dominguez AA, Lim WA, Qi LS. Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation. Nat Rev Mol Cell Biol. 2016 Jan;17(1):5-15. doi: 10.1038/nrm.2015.2. Epub 2015 Dec 16. PubMed PMID: 26670017.
  5. Tabebordbar M, Zhu K, Cheng JK, Chew WL, Widrick JJ, Yan WX, Maesner C, Wu EY, Xiao R, Ran FA, Cong L, Zhang F, Vandenberghe LH, Church GM, Wagers AJ. In vivo gene editing in dystrophic mouse muscle and muscle stem cells. Science. 2015 Dec 31. pii: aad5177. [Epub ahead of print] PubMed PMID: 26721686.
  6. Nelson CE, Hakim CH, Ousterout DG, Thakore PI, Moreb EA, Rivera RM, Madhavan S, Pan X, Ran FA, Yan WX, Asokan A, Zhang F, Duan D, Gersbach CA. In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy. Science. 2015 Dec 31. pii: aad5143. [Epub ahead of print] PubMed PMID: 26721684.
  7. Long C, Amoasii L, Mireault AA, McAnally JR, Li H, Sanchez-Ortiz E, Bhattacharyya S, Shelton JM, Bassel-Duby R, Olson EN. Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy. Science. 2015 Dec 31. pii: aad5725. [Epub ahead of print] PubMed PMID: 26721683.

Neuroscience

  1. Paonessa F, Criscuolo S, Sacchetti S, Amoroso D, Scarongella H, Pecoraro Bisogni F, Carminati E, Pruzzo G, Maragliano L, Cesca F, Benfenati F. Regulation of neural gene transcription by optogenetic inhibition of the RE1-silencing transcription factor. Proc Natl Acad Sci U S A. 2015 Dec 23. pii: 201507355. [Epub ahead of print] PubMed PMID: 26699507.

Imaging

  1. Tomer R, Lovett-Barron M, Kauvar I, Andalman A, Burns VM, Sankaran S, Grosenick L, Broxton M, Yang S, Deisseroth K. SPED Light Sheet Microscopy: Fast Mapping of Biological System Structure and Function. Cell. 2015 Dec 17;163(7):1796-806. doi: 10.1016/j.cell.2015.11.061. PubMed PMID: 26687363.

				

Genome Editing

  1. Bolukbasi MF, Gupta A, Oikemus S, Derr AG, Garber M, Brodsky MH, Zhu LJ, Wolfe SA. DNA-binding-domain fusions enhance the targeting range and precision of Cas9. Nat Methods. 2015 Oct 19. doi: 10.1038/nmeth.3624. [Epub ahead of print] PubMed PMID: 26480473.
  2. Thakore PI, D’Ippolito AM, Song L, Safi A, Shivakumar NK, Kabadi AM, Reddy TE, Crawford GE, Gersbach CA. Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. Nat Methods. 2015 Oct 26. doi: 10.1038/nmeth.3630. [Epub ahead of print] PubMed PMID: 26501517.
  3. Nature Outlook: Genome Editing

Science Career

  1. Ma A, Mondragón RJ, Latora V. Anatomy of funded research in science. Proc Natl Acad Sci U S A. 2015 Oct 26. pii: 201513651. [Epub ahead of print] PubMed PMID: 26504240.
  2. Gould J. How to build a better PhD. Nature. 2015 Dec 2;528(7580):22-5. doi: 10.1038/528022a. PubMed PMID: 26632571.
  3. Make the most of PhDs. Nature. 2015 Dec 2;528(7580):7. doi: 10.1038/528007a. PubMed PMID: 26632550.

Neuroscience

  1. Nikolaou N, Meyer MP. Lamination Speeds the Functional Development of Visual Circuits. Neuron. 2015 Nov 18. pii: S0896-6273(15)00886-7. doi: 10.1016/j.neuron.2015.10.020. [Epub ahead of print] PubMed PMID: 26607001.

Medicine

  1. Pankow S, Bamberger C, Calzolari D, Martínez-Bartolomé S, Lavallée-Adam M, Balch WE, Yates JR 3rd. ∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature. 2015 Nov 30. doi: 10.1038/nature15729. [Epub ahead of print] PubMed PMID: 26618866.

Development

  1. Li IJ, Chang CJ, Liu SC, Abe G, Ota KG. Postembryonic staging of wild-type goldfish, with brief reference to skeletal systems. Dev Dyn. 2015 Aug 28. doi: 10.1002/dvdy.24340. [Epub ahead of print] PubMed PMID: 26316229.

Systems Biology

  1. Keren L, van Dijk D, Weingarten-Gabbay S, Davidi D, Jona G, Weinberger A, Milo R, Segal E. Noise in gene expression is coupled to growth rate. Genome Res. 2015 Dec;25(12):1893-902. doi: 10.1101/gr.191635.115. Epub 2015 Sep 9. PubMed PMID: 26355006.

Imaging

  1. Ariotti N, Hall TE, Rae J, Ferguson C, McMahon KA, Martel N, Webb RE, Webb RI, Teasdale RD, Parton RG. Modular Detection of GFP-Labeled Proteins for Rapid Screening by Electron Microscopy in Cells and Organisms. Dev Cell. 2015 Nov 11. pii: S1534-5807(15)00681-4. doi: 10.1016/j.devcel.2015.10.016. [Epub ahead of print] PubMed PMID: 26585296.

Genomics

  1. Bhaduri A, Ungewickell A, Boxer LD, Lopez-Pajares V, Zarnegar BJ, Khavari PA. Network Analysis Identifies Mitochondrial Regulation of Epidermal Differentiation by MPZL3 and FDXR. Dev Cell. 2015 Nov 23;35(4):444-57. doi: 10.1016/j.devcel.2015.10.023. PubMed PMID: 26609959.
  2. Jin W, Tang Q, Wan M, Cui K, Zhang Y, Ren G, Ni B, Sklar J, Przytycka TM, Childs R, Levens D, Zhao K. Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples. Nature. 2015 Nov 25. doi: 10.1038/nature15740. [Epub ahead of print] PubMed PMID: 26605532.
  3. Mathieson I, Lazaridis I, Rohland N, Mallick S, Patterson N, Roodenberg SA, Harney E, Stewardson K, Fernandes D, Novak M, Sirak K, Gamba C, Jones ER, Llamas B, Dryomov S, Pickrell J, Arsuaga JL, de Castro JM, Carbonell E, Gerritsen F, Khokhlov A, Kuznetsov P, Lozano M, Meller H, Mochalov O, Moiseyev V, Guerra MA, Roodenberg J, Vergès JM, Krause J, Cooper A, Alt KW, Brown D, Anthony D, Lalueza-Fox C, Haak W, Pinhasi R, Reich D. Genome-wide patterns of selection in 230 ancient Eurasians. Nature. 2015 Nov 23. doi: 10.1038/nature16152. [Epub ahead of print] PubMed PMID: 26595274.

Medicine

  1. Tanaka A, Nagayoshi M, Takemoto Y, Tanaka I, Kusunoki H, Watanabe S, Kuroda K, Takeda S, Ito M, Yanagimachi R. Fourteen babies born after round spermatid injection into human oocytes. Proc Natl Acad Sci U S A. 2015 Nov 2. pii: 201517466. [Epub ahead of print] PubMed PMID: 26575628.
  2. Fischer KR, Durrans A, Lee S, Sheng J, Li F, Wong ST, Choi H, El Rayes T, Ryu S, Troeger J, Schwabe RF, Vahdat LT, Altorki NK, Mittal V, Gao D. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature. 2015 Nov 11. doi: 10.1038/nature15748. [Epub ahead of print] PubMed PMID: 26560033. Nature Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides

Neuroscience

  1. Hawrylycz M, Miller JA, Menon V, Feng D, Dolbeare T, Guillozet-Bongaarts AL, Jegga AG, Aronow BJ, Lee CK, Bernard A, Glasser MF, Dierker DL, Menche J, Szafer A, Collman F, Grange P, Berman KA, Mihalas S, Yao Z, Stewart L, Barabási AL, Schulkin J, Phillips J, Ng L, Dang C, Haynor DR, Jones A, Van Essen DC, Koch C, Lein E. Canonical genetic signatures of the adult human brain. Nat Neurosci. 2015 Nov 16. doi: 10.1038/nn.4171. [Epub ahead of print] PubMed PMID: 26571460.
  2. Sharma K, Schmitt S, Bergner CG, Tyanova S, Kannaiyan N, Manrique-Hoyos N, Kongi K, Cantuti L, Hanisch UK, Philips MA, Rossner MJ, Mann M, Simons M. Cell type- and brain region-resolved mouse brain proteome. Nat Neurosci. 2015 Nov 2. doi: 10.1038/nn.4160. [Epub ahead of print] PubMed PMID: 26523646.
  3. Rost BR, Schneider F, Grauel MK, Wozny C, G Bentz C, Blessing A, Rosenmund T, Jentsch TJ, Schmitz D, Hegemann P, Rosenmund C. Optogenetic acidification of synaptic vesicles and lysosomes. Nat Neurosci. 2015 Nov 9. doi: 10.1038/nn.4161. [Epub ahead of print] PubMed PMID: 26551543.

Genome editing

  1. Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA. Foreign DNA capture during CRISPR-Cas adaptive immunity. Nature. 2015 Oct 21. doi: 10.1038/nature15760. [Epub ahead of print] PubMed PMID: 26503043.

 

Population Genetics

  1. Balaresque P, Poulet N, Cussat-Blanc S, Gerard P, Quintana-Murci L, Heyer E, Jobling MA. Y-chromosome descent clusters and male differential reproductive success: young lineage expansions dominate Asian pastoral nomadic populations. Eur J Hum Genet. 2015 Jan 14. doi: 10.1038/ejhg.2014.285. [Epub ahead of print] PubMed PMID: 25585703.

Evolution

  1. Head JJ, Polly PD. Evolution of the snake body form reveals homoplasy in amniote Hox gene function. Nature. 2015 Jan 5. doi: 10.1038/nature14042. [Epub ahead of print] PubMed PMID: 25539083.
  2. Lewis SL, Maslin MA. Defining the anthropocene. Nature. 2015 Mar 12;519(7542):171-80. doi: 10.1038/nature14258. PubMed PMID: 25762280.

Research Career

  1. 10 things not enough kids know before going to college
  2. Powell K. The future of the postdoc. Nature. 2015 Apr 9;520(7546):144-7. doi: 10.1038/520144a. PubMed PMID: 25855437.
  3. Will declining funding stunt scientific discovery in the U.S.?
  4. Who Picks Up the Tab for Science?

Imaging

  1. Chen F, Tillberg PW, Boyden ES. Optical imaging. Expansion microscopy. Science. 2015 Jan 30;347(6221):543-8. doi: 10.1126/science.1260088. Epub 2015 Jan 15. PubMed PMID: 25592419; PubMed Central PMCID: PMC4312537.

Medicine

  1. Leinenga G, Götz J. Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model. Sci Transl Med. 2015 Mar 11;7(278):278ra33. doi: 10.1126/scitranslmed.aaa2512. PubMed PMID: 25761889.
    1. New Alzheimer’s treatment fully restores memory function
  2. Kawchuk GN, Fryer J, Jaremko JL, Zeng H, Rowe L, Thompson R. Real-time visualization of joint cavitation. PLoS One. 2015 Apr 15;10(4):e0119470. doi: 10.1371/journal.pone.0119470. eCollection 2015. PubMed PMID: 25875374; PubMed Central PMCID: PMC4398549.
  3. Ganna A, Ingelsson E. 5 year mortality predictors in 498 103 UK Biobank participants: a prospective population-based study. Lancet. 2015 Jun 2. pii: S0140-6736(15)60175-1. doi: 10.1016/S0140-6736(15)60175-1. [Epub ahead of print] PubMed PMID: 26049253.

Medicine/Prosthetics

  1. Men have hands amputated and replaced with bionic ones
  2. Lab In Berkeley Accidentally Discovers Solution To Fix Color Blindness

Chemistry

  1. This Chemistry 3D Printer Can Synthesize Molecules From Scratch

Genomics

  1. Ji X, Dadon DB, Abraham BJ, Lee TI, Jaenisch R, Bradner JE, Young RA. Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions. Proc Natl Acad Sci U S A. 2015 Mar 9. pii: 201502971. [Epub ahead of print] PubMed PMID: 25755260.
  2. Chen KH, Boettiger AN, Moffitt JR, Wang S, Zhuang X. Spatially resolved, highly multiplexed RNA profiling in single cells. Science. 2015 Apr 9. pii: aaa6090. PubMed PMID: 25858977.

General

  1. Baden T, Chagas AM, Gage G, Marzullo T, Prieto-Godino LL, Euler T. Open labware: 3-d printing your own lab equipment. PLoS Biol. 2015 Mar 20;13(3):e1002086. doi: 10.1371/journal.pbio.1002086. eCollection 2015 Mar. PubMed PMID: 25794301.

Development

  1. Campbell PD, Chao JA, Singer RH, Marlow FL. Dynamic visualization of transcription and RNA subcellular localization in zebrafish. Development. 2015 Mar 10. pii: dev.118968. [Epub ahead of print] PubMed PMID: 25758462.
  2. Green JB, Sharpe J. Positional information and reaction-diffusion: two big ideas in developmental biology combine. Development. 2015 Apr 1;142(7):1203-1211. Review. PubMed PMID: 25804733.
  3. Wu F, Kaczynski TJ, Sethuramanujam S, Li R, Jain V, Slaughter M, Mu X. Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc Natl Acad Sci U S A. 2015 Mar 16. pii: 201421535. [Epub ahead of print] PubMed PMID: 25775587.
  4. Nern A, Pfeiffer BD, Rubin GM. Optimized tools for multicolor stochastic labeling reveal diverse stereotyped cell arrangements in the fly visual system.Proc Natl Acad Sci U S A. 2015 May 11. pii: 201506763. [Epub ahead of print] PubMed PMID: 25964354.

Neuroscience

  1. Lichtman JW, Pfister H, Shavit N. The big data challenges of connectomics. Nat Neurosci. 2014 Nov;17(11):1448-54. doi: 10.1038/nn.3837. Epub 2014 Oct 28. Review. PubMed PMID: 25349911.
  2. Hayworth KJ, Xu CS, Lu Z, Knott GW, Fetter RD, Tapia JC, Lichtman JW, Hess HF.
    Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics. Nat Methods. 2015 Apr;12(4):319-22. doi: 10.1038/nmeth.3292. Epub 2015 Feb 16. PubMed PMID: 25686390; PubMed Central PMCID: PMC4382383.
  3. Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, Tsai LH. Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes. Cell. 2015 Jun 18;161(7):1592-605. doi: 10.1016/j.cell.2015.05.032. Epub 2015 Jun 4. PubMed PMID: 26052046.

Genetics/Genome Editing

  1. Yin L, Maddison LA, Li M, Kara N, LaFave MC, Varshney GK, Burgess SM, Patton JG, Chen W. Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs. Genetics. 2015 Apr 8. pii: genetics.115.176917. [Epub ahead of print] PubMed PMID: 25855067.
  2. Gonzales AP, Yeh JR. Cas9-based genome editing in zebrafish. Methods Enzymol. 2014;546:377-413. doi: 10.1016/B978-0-12-801185-0.00018-0. PubMed PMID: 25398350.
  3. Shah AN, Davey CF, Whitebirch AC, Miller AC, Moens CB. Rapid reverse genetic screening using CRISPR in zebrafish. Nat Methods. 2015 Jun;12(6):535-40. doi: 10.1038/nmeth.3360. Epub 2015 Apr 13. PubMed PMID: 25867848.
  4. Dow LE, Fisher J, O’Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci ND, Lowe SW. Inducible in vivo genome editing with CRISPR-Cas9. Nat Biotechnol. 2015 Apr;33(4):390-4. doi: 10.1038/nbt.3155. Epub 2015 Feb 18. PubMed PMID: 25690852; PubMed Central PMCID: PMC4390466.

Cell cycle

  1. Malumbres M. Cyclin-dependent kinases. Genome Biol. 2014;15(6):122. PubMed PMID: 25180339; PubMed Central PMCID: PMC4097832.

Sequencing/Disease

  1. Gilissen C, Hehir-Kwa JY, Thung DT, van de Vorst M, van Bon BW, Willemsen MH, Kwint M, Janssen IM, Hoischen A, Schenck A, Leach R, Klein R, Tearle R, Bo T, Pfundt R, Yntema HG, de Vries BB, Kleefstra T, Brunner HG, Vissers LE, Veltman JA. Genome sequencing identifies major causes of severe intellectual disability.  Nature. 2014 Jul 17;511(7509):344-7. doi: 10.1038/nature13394. Epub 2014 Jun 4. PubMed PMID: 24896178.

Retina

  1. Labin AM, Safuri SK, Ribak EN, Perlman I. Müller cells separate between wavelengths to improve day vision with minimal effect upon night vision. Nat Commun. 2014 Jul 8;5:4319. doi: 10.1038/ncomms5319. PubMed PMID: 25003477.
  2. Busskamp V, Krol J, Nelidova D, Daum J, Szikra T, Tsuda B, Jüttner J, Farrow K, Scherf BG, Alvarez CP, Genoud C, Sothilingam V, Tanimoto N, Stadler M, Seeliger M, Stoffel M, Filipowicz W, Roska B. miRNAs 182 and 183 Are Necessary to Maintain Adult Cone Photoreceptor Outer Segments and Visual Function. Neuron. 2014 Jul 4. pii: S0896-6273(14)00542-X. doi: 10.1016/j.neuron.2014.06.020. [Epub ahead of print] PubMed PMID: 25002228.
  3. Condition Called Tetrachromacy Allows This Artist To See 100 Million Colors

Neurodegeneration

  1. Games D, Valera E, Spencer B, Rockenstein E, Mante M, Adame A, Patrick C, Ubhi K, Nuber S, Sacayon P, Zago W, Seubert P, Barbour R, Schenk D, Masliah E. Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson’s disease-like models. J Neurosci. 2014 Jul 9;34(28):9441-54. doi: 10.1523/JNEUROSCI.5314-13.2014. PubMed PMID: 25009275.
  2. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014 Jul 24;511(7510):421-7. doi: 10.1038/nature13595. Epub 2014 Jul 22. PubMed PMID:25056061; PubMed Central PMCID: PMC4112379.

Neurobiology

  1. Severi KE, Portugues R, Marques JC, O’Malley DM, Orger MB, Engert F. Neural control and modulation of swimming speed in the larval zebrafish. Neuron. 2014 Aug 6;83(3):692-707. doi: 10.1016/j.neuron.2014.06.032. Epub 2014 Jul 24. PubMed PMID: 25066084; PubMed Central PMCID: PMC4126853.
  2. Bruni G, Lakhani P, Kokel D. Discovering novel neuroactive drugs through
    high-throughput behavior-based chemical screening in the zebrafish. Front
    Pharmacol. 2014 Jul 24;5:153. doi: 10.3389/fphar.2014.00153. eCollection 2014. Review. PubMed PMID: 25104936; PubMed Central PMCID: PMC4109429.

Ethical, Social and Legal Issues

  1. Tort AB, Targino ZH, Amaral OB. Rising publication delays inflate journal impact factors. PLoS One. 2012;7(12):e53374. doi: 10.1371/journal.pone.0053374. Epub 2012 Dec 31. PubMed PMID: 23300920; PubMed Central PMCID: PMC3534064.
  2. van Lent M, Overbeke J, Out HJ. Role of editorial and peer review processes in publication bias: analysis of drug trials submitted to eight medical journals. PLoS One. 2014 Aug 12;9(8):e104846. doi: 10.1371/journal.pone.0104846. eCollection 2014. PubMed PMID: 25118182; PubMed Central PMCID: PMC4130599.
  3. Ioannidis JP. How to make more published research true. PLoS Med. 2014 Oct 21;11(10):e1001747. doi: 10.1371/journal.pmed.1001747. eCollection 2014 Oct. PubMed PMID: 25334033; PubMed Central PMCID: PMC4204808.

Stem cells

  1. Pagliuca FW, Millman JR, Gürtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA. Generation of Functional Human Pancreatic β Cells In Vitro. Cell. 2014 Oct 9;159(2):428-39. doi: 10.1016/j.cell.2014.09.040. PubMed PMID: 25303535.
  2. Zhang D, Pekkanen-Mattila M, Shahsavani M, Falk A, Teixeira AI, Herland A. A 3D Alzheimer’s disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons. Biomaterials. 2014 Feb;35(5):1420-8. doi: 10.1016/j.biomaterials.2013.11.028. Epub 2013 Nov 27. PubMed PMID: 24290439.
  3. Schwartz SD, et al., Human embryonic stem cell-derived retinal pigment
    epithelium in patients with age-related macular degeneration and Stargardt’s macular dystrophy: follow-up of two open-label phase 1/2 studies. Lancet 2014. In press.

Genome editing

  1. Lombardo A, Naldini L. Genome Editing: A Tool For Research and Therapy: Targeted genome editing hits the clinic. Nat Med. 2014 Oct 8;20(10):1101-3. doi: 10.1038/nm.3721. PubMed PMID: 25295939.

Nutrition

  1. Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014 Oct 9;514(7521):181-6. doi: 10.1038/nature13793. Epub 2014 Sep 17. PubMed PMID: 25231862.

Molecular biology

  1. Robart AR, Chan RT, Peters JK, Rajashankar KR, Toor N. Crystal structure of a eukaryotic group II intron lariat. Nature. 2014 Oct 9;514(7521):193-7. doi: 10.1038/nature13790. Epub 2014 Sep 24. PubMed PMID: 25252982.

Imaging

  1. Chen BC, Legant WR, Wang K, Shao L, Milkie DE, Davidson MW, Janetopoulos C, Wu XS, Hammer JA 3rd, Liu Z, English BP, Mimori-Kiyosue Y, Romero DP, Ritter AT, Lippincott-Schwartz J, Fritz-Laylin L, Mullins RD, Mitchell DM, Bembenek JN, Reymann AC, Böhme R, Grill SW, Wang JT, Seydoux G, Tulu US, Kiehart DP, Betzig E. Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution. Science. 2014 Oct 24;346(6208):1257998. doi:
    10.1126/science.1257998. Epub 2014 Oct 23. PubMed PMID: 25342811.
    Wang K, Milkie DE, Saxena A, Engerer P, Misgeld T, Bronner ME, Mumm J, Betzig E. Rapid adaptive optical recovery of optimal resolution over large volumes. Nat Methods. 2014 Jun;11(6):625-8. doi: 10.1038/nmeth.2925. Epub 2014 Apr 13. PubMed PMID: 24727653; PubMed Central PMCID: PMC4069208.
  2. Amat F, Lemon W, Mossing DP, McDole K, Wan Y, Branson K, Myers EW, Keller PJ. Fast, accurate reconstruction of cell lineages from large-scale fluorescence microscopy data. Nat Methods. 2014 Jul 20. doi: 10.1038/nmeth.3036. [Epub ahead of print] PubMed PMID: 25042785.

Evolution

  1. Rands CM, Meader S, Ponting CP, Lunter G. 8.2% of the Human genome is constrained: variation in rates of turnover across functional element classes in the human lineage. PLoS Genet. 2014 Jul 24;10(7):e1004525. doi:
    10.1371/journal.pgen.1004525. eCollection 2014 Jul. PubMed PMID: 25057982; PubMed Central PMCID: PMC4109858.
  2. News coverage: Only 8.2 % of Human DNA is Functional, Say Genetic Researchers