Posts tagged ‘behaviour’

Behaviour

  1. Palmér T, Ek F, Enqvist O, Olsson R, Åström K, Petersson P. Action sequencing in the spontaneous swimming behavior of zebrafish larvae – implications for drug development. Sci Rep. 2017 Jun 9;7(1):3191. doi: 10.1038/s41598-017-03144-7. PubMed PMID: 28600565; PubMed Central PMCID: PMC5466685.
  2. Vliet SM, Ho TC, Volz DC. Behavioral screening of the LOPAC(1280) library in zebrafish embryos. Toxicol Appl Pharmacol. 2017 Jun 13. pii: S0041-008X(17)30267-3. doi: 10.1016/j.taap.2017.06.011. [Epub ahead of print] PubMed PMID: 28623180.

Funding

  1. Kaiser J. NIH abandons grant cap, offers new help to younger scientists. Science. 2017 Jun 16;356(6343):1108. doi: 10.1126/science.356.6343.1108. PubMed PMID: 28619891.
  2. Wahls WP. NIH’s ineffective funding policies. Science. 2017 Jun 16;356(6343):1132-1133. doi: 10.1126/science.aan6504. PubMed PMID: 28619908.

Genetics

  1. Cassels L, Barde YA. Scaling pain threshold with microRNAs. Science. 2017 Jun 16;356(6343):1124-1125. doi: 10.1126/science.aan6784. PubMed PMID: 28619901.
  2. Peng C, Li L, Zhang MD, Bengtsson Gonzales C, Parisien M, Belfer I, Usoskin D, Abdo H, Furlan A, Häring M, Lallemend F, Harkany T, Diatchenko L, Hökfelt T, Hjerling-Leffler J, Ernfors P. miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. Science. 2017 Jun 16;356(6343):1168-1171. doi: 10.1126/science.aam7671. Epub 2017 Jun 1. PubMed PMID: 28572455.

Genomics

  1. Shekhar K, Lapan SW, Whitney IE, Tran NM, Macosko EZ, Kowalczyk M, Adiconis X, Levin JZ, Nemesh J, Goldman M, McCarroll SA, Cepko CL, Regev A, Sanes JR. Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics. Cell. 2016 Aug 25;166(5):1308-1323.e30. doi: 10.1016/j.cell.2016.07.054. PubMed PMID: 27565351; PubMed Central PMCID: PMC5003425.

Vision

  1. Sabbah S, Gemmer JA, Bhatia-Lin A, Manoff G, Castro G, Siegel JK, Jeffery N, Berson DM. A retinal code for motion along the gravitational and body axes. Nature. 2017 Jun 7. doi: 10.1038/nature22818. [Epub ahead of print] PubMed PMID: 28607486.
  2. Demb JB, Clark DA. Vision: These retinas are made for walkin’. Nature. 2017 Jun 7. doi: 10.1038/nature22505. [Epub ahead of print] PubMed PMID: 28607483

Genome editing

  1. Stella S, Alcón P, Montoya G. Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage. Nature. 2017 May 31. doi: 10.1038/nature22398. [Epub ahead of print] PubMed PMID: 28562584.
  2. Palermo G, Miao Y, Walker RC, Jinek M, McCammon JA. CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations. Proc Natl Acad Sci U S A. 2017 Jun 26. pii: 201707645. doi: 10.1073/pnas.1707645114. [Epub ahead of print] PubMed PMID: 28652374.
  3. Shipman SL, Nivala J, Macklis JD, Church GM. CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria. Nature. 2017 Jul 12. doi: 10.1038/nature23017. [Epub ahead of print] PubMed PMID: 28700573.

Stem cell

  1. Servick K. Stem cell approach for cataracts challenged. Science. 2017 Jun 30;356(6345):1318-1319. doi: 10.1126/science.356.6345.1318. PubMed PMID: 28663449.

Eye disease

  1. Servick K. Stem cell approach for cataracts challenged. Science. 2017 Jun 30;356(6345):1318-1319. doi: 10.1126/science.356.6345.1318. PubMed PMID: 28663449.

Ecology/Evolution

  1. Ceballos G, Ehrlich PR, Dirzo R. Biological annihilation via the ongoing sixth mass extinction signaled by vertebrate population losses and declines. Proc Natl Acad Sci U S A. 2017 Jul 10. pii: 201704949. doi: 10.1073/pnas.1704949114. [Epub ahead of print] PubMed PMID: 28696295.
  2. Castiglione GM, Hauser FE, Liao BS, Lujan NK, Van Nynatten A, Morrow JM, Schott RK, Bhattacharyya N, Dungan SZ, Chang BSW. Evolution of nonspectral rhodopsin function at high altitudes. Proc Natl Acad Sci U S A. 2017 Jun 22. pii: 201705765. doi: 10.1073/pnas.1705765114. [Epub ahead of print] PubMed PMID: 28642345.

Imaging

  1. Hildebrand DGC, Cicconet M, Torres RM, Choi W, Quan TM, Moon J, Wetzel AW, Scott Champion A, Graham BJ, Randlett O, Plummer GS, Portugues R, Bianco IH, Saalfeld S, Baden AD, Lillaney K, Burns R, Vogelstein JT, Schier AF, Lee WA, Jeong WK, Lichtman JW, Engert F. Whole-brain serial-section electron microscopy in larval zebrafish. Nature. 2017 May 18;545(7654):345-349. doi: 10.1038/nature22356. Epub 2017 May 10. PubMed PMID: 28489821.

Neuroscience

  1. Ciabatti E, González-Rueda A, Mariotti L, Morgese F, Tripodi M. Life-Long Genetic and Functional Access to Neural Circuits Using Self-Inactivating Rabies Virus. Cell. 2017 Jul 1. pii: S0092-8674(17)30697-9. doi: 10.1016/j.cell.2017.06.014. [Epub ahead of print] PubMed PMID: 28689641.

Development

  1. Baxendale S, Whitfield TT. Methods to study the development, anatomy, and function of the zebrafish inner ear across the life course. Methods Cell Biol. 2016;134:165-209. doi: 10.1016/bs.mcb.2016.02.007. Epub 2016 Mar 9. PubMed PMID: 27312494.
  2. Simoes-Costa M, Bronner ME. Reprogramming of avian neural crest axial identity and cell fate. Science. 2016 Jun 24;352(6293):1570-3. doi: 10.1126/science.aaf2729. PubMed PMID: 27339986.

Genetics

  1. Birney E, Smith GD, Greally JM. Epigenome-wide Association Studies and the Interpretation of Disease -Omics. PLoS Genet. 2016 Jun 23;12(6):e1006105. doi: 10.1371/journal.pgen.1006105. eCollection 2016 Jun. Review. PubMed PMID: 27336614.

Molecular Biology

  1. Ellefson JW, Gollihar J, Shroff R, Shivram H, Iyer VR, Ellington AD. Synthetic evolutionary origin of a proofreading reverse transcriptase. Science. 2016 Jun 24;352(6293):1590-3. doi: 10.1126/science.aaf5409. PubMed PMID: 27339990.

Genome Editing

  1. Feng Y, Chen C, Han Y, Chen Z, Lu X, Liang F, Li S, Qin W, Lin S. Expanding CRISPR/Cas9 Genome Editing Capacity in Zebrafish Using SaCas9. G3 (Bethesda). 2016 Jun 17. pii: g3.116.031914. doi: 10.1534/g3.116.031914. [Epub ahead of print] PubMed PMID: 27317783.

Behaviour

  1. Peeters BW, Moeskops M, Veenvliet AR. Color Preference in Danio rerio: Effects of Age and Anxiolytic Treatments. Zebrafish. 2016 Aug;13(4):330-4. doi: 10.1089/zeb.2015.1150. PubMed PMID: 27333080.

Stem cells

  1. Clevers H. Modeling Development and Disease with Organoids. Cell. 2016 Jun 16;165(7):1586-97. doi: 10.1016/j.cell.2016.05.082. Review. PubMed PMID: 27315476.

Retina

  1. Malicki J, Pooranachandran N, Nikolaev A, Fang X, Avanesov A. Analysis of the retina in the zebrafish model. Methods Cell Biol. 2016;134:257-334. doi: 10.1016/bs.mcb.2016.04.017. Epub 2016 Jun 2. PubMed PMID: 27312496.
  2. Kim JW, Yang HJ, Oel AP, Brooks MJ, Jia L, Plachetzki DC, Li W, Allison WT, Swaroop A. Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals. Dev Cell. 2016 Jun 20;37(6):520-32. doi: 10.1016/j.devcel.2016.05.023. PubMed PMID: 27326930; PubMed Central PMCID: PMC4918105.


				

Genomics

  1. Bintu L, Yong J, Antebi YE, McCue K, Kazuki Y, Uno N, Oshimura M, Elowitz MB. Dynamics of epigenetic regulation at the single-cell level. Science. 2016 Feb 12;351(6274):720-4. doi: 10.1126/science.aab2956. PubMed PMID: 26912859.
    • Commentary: Keung AJ, Khalil AS. MOLECULAR BIOLOGY. A unifying model of epigenetic regulation. Science. 2016 Feb 12;351(6274):661-2. doi: 10.1126/science.aaf1647. PubMed PMID: 26912843.
  2. Cahan P. Enabling direct fate conversion with network biology. Nat Genet. 2016 Feb 24;48(3):226-7. doi: 10.1038/ng.3516. PubMed PMID: 26906680.
  3. Rackham OJ, Firas J, Fang H, Oates ME, Holmes ML, Knaupp AS; FANTOM Consortium, Suzuki H, Nefzger CM, Daub CO, Shin JW, Petretto E, Forrest AR, Hayashizaki Y, Polo JM, Gough J. A predictive computational framework for direct reprogramming between human cell types. Nat Genet. 2016 Jan 18. doi: 10.1038/ng.3487. [Epub ahead of print] PubMed PMID: 26780608.
  4. Savova V, Chun S, Sohail M, McCole RB, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA. Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Nat Genet. 2016 Jan 25. doi: 10.1038/ng.3493. [Epub ahead of print] PubMed PMID: 26808112.
  5. Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BW, Jansen R, de Geus EJ, Boomsma DI, Wright FA, Sullivan PF, Nikkola E, Alvarez M, Civelek M, Lusis AJ, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Raitakari OT, Kuusisto J, Laakso M, Price AL, Pajukanta P, Pasaniuc B. Integrative approaches for large-scale transcriptome-wide association studies. Nat Genet. 2016 Feb 8. doi: 10.1038/ng.3506. [Epub ahead of print] PubMed PMID: 26854917.

Development

  1. Aggarwal V, Dickinson RB, Lele TP. Concentration Sensing by the Moving Nucleus in Cell Fate Determination: A Computational Analysis. PLoS One. 2016 Feb 12;11(2):e0149213. doi: 10.1371/journal.pone.0149213. eCollection 2016. PubMed PMID: 26872214.
  2. Rackham OJ, Firas J, Fang H, Oates ME, Holmes ML, Knaupp AS; FANTOM Consortium, Suzuki H, Nefzger CM, Daub CO, Shin JW, Petretto E, Forrest AR, Hayashizaki Y, Polo JM, Gough J. A predictive computational framework for direct reprogramming between human cell types. Nat Genet. 2016 Jan 18. doi: 10.1038/ng.3487. [Epub ahead of print] PubMed PMID: 26780608.

Molecular Biology

  1. Burgers PM, Gordenin D, Kunkel TA. Who Is Leading the Replication Fork, Pol ε or Pol δ? Mol Cell. 2016 Feb 18;61(4):492-3. doi: 10.1016/j.molcel.2016.01.017. PubMed PMID: 26895421.
  2. Johnson RE, Klassen R, Prakash L, Prakash S. Response to Burgers et al. Mol Cell. 2016 Feb 18;61(4):494-5. doi: 10.1016/j.molcel.2016.01.018. PubMed PMID: 26895422.

Funding

  1.  Vachelard J, Gambarra-Soares T, Augustini G, Riul P, Maracaja-Coutinho V. A Guide to Scientific Crowdfunding. PLoS Biol. 2016 Feb 17;14(2):e1002373. doi: 10.1371/journal.pbio.1002373. eCollection 2016 Feb. PubMed PMID: 26886064.

Genome editing

  1. Tai DJ, Ragavendran A, Manavalan P, Stortchevoi A, Seabra CM, Erdin S, Collins RL, Blumenthal I, Chen X, Shen Y, Sahin M, Zhang C, Lee C, Gusella JF, Talkowski ME. Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR. Nat Neurosci. 2016 Feb 1. doi: 10.1038/nn.4235. [Epub ahead of print] PubMed PMID: 26829649.

Behaviour

  1. Scott CA, Marsden AN, Slusarski DC. Automated, high-throughput, in vivo analysis of visual function using the zebrafish. Dev Dyn. 2016 Feb 18. doi: 10.1002/dvdy.24398. [Epub ahead of print] PubMed PMID: 26890697.

Stem cells

  1. Fatehullah A, Tan SH, Barker N. Organoids as an in vitro model of human development and disease. Nat Cell Biol. 2016 Feb 25;18(3):246-54. doi: 10.1038/ncb3312. Review. PubMed PMID: 26911908.
  2. Wang Y, Gao S. Human Naive Embryonic Stem Cells: How Full Is the Glass? Cell Stem Cell. 2016 Mar 3;18(3):301-3. doi: 10.1016/j.stem.2016.02.012. PubMed PMID: 26942847.
  3. Pastor WA, Chen D, Liu W, Kim R, Sahakyan A, Lukianchikov A, Plath K, Jacobsen SE, Clark AT. Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory. Cell Stem Cell. 2016 Mar 3;18(3):323-9. doi: 10.1016/j.stem.2016.01.019. Epub 2016 Feb 4. PubMed PMID: 26853856; PubMed Central PMCID: PMC4779431.
  4. Passier R, Orlova V, Mummery C. Complex Tissue and Disease Modeling using hiPSCs. Cell Stem Cell. 2016 Mar 3;18(3):309-21. doi: 10.1016/j.stem.2016.02.011. Review. PubMed PMID: 26942851.
  5. Orlova V, Mummery C. SnapShot: Key Advances in hiPSC Disease Modeling. Cell Stem Cell. 2016 Mar 3;18(3):422. doi: 10.1016/j.stem.2016.02.013. PubMed PMID: 26942854.
  6. Nat Rev Mol Cell Biol; Focus on: Pluripotent Stem cells

Medicine

  1. Peplow M. Synthetic biology’s first malaria drug meets market resistance. Nature. 2016 Feb 25;530(7591):389-90. doi: 10.1038/530390a. PubMed PMID: 26911755.

Genome editing

  1. Hayes RP, Xiao Y, Ding F, van Erp PB, Rajashankar K, Bailey S, Wiedenheft B, Ke A. Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature. 2016 Feb 10. doi: 10.1038/nature16995. [Epub ahead of print] PubMed PMID: 26863189.

Eye disease

  1. Fritsche LG, et al. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet. 2015 Dec 21. doi: 10.1038/ng.3448. [Epub ahead of print] PubMed PMID: 26691988.

Zebrafish Behaviour

  1. Prykhozhij SV, Rajan V, Berman JN. A Guide to Computational Tools and Design Strategies for Genome Editing Experiments in Zebrafish Using CRISPR/Cas9. Zebrafish. 2015 Dec 18. [Epub ahead of print] PubMed PMID: 26683213.
  2. Gao Y, Zhang G, Jelfs B, Carmer R, Venkatraman P, Ghadami M, Brown SA, Pang CP, Leung YF, Chan RH, Zhang M. Computational classification of different wild-type zebrafish strains based on their variation in light-induced locomotor response. Comput Biol Med. 2015 Nov 30;69:1-9. doi: 10.1016/j.compbiomed.2015.11.012. [Epub ahead of print] PubMed PMID: 26688204.

Genome Editing

  1. Sakuma T, Nakade S, Sakane Y, Suzuki KT, Yamamoto T. MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems. Nat Protoc. 2016 Jan;11(1):118-33. doi: 10.1038/nprot.2015.140. Epub 2015 Dec 17. PubMed PMID: 26678082.
  2. Lackner DH, Carré A, Guzzardo PM, Banning C, Mangena R, Henley T, Oberndorfer S, Gapp BV, Nijman SM, Brummelkamp TR, Bürckstümmer T. A generic strategy for CRISPR-Cas9-mediated gene tagging. Nat Commun. 2015 Dec 17;6:10237. doi: 10.1038/ncomms10237. PubMed PMID: 26674669.
  3. Prykhozhij SV, Rajan V, Berman JN. A Guide to Computational Tools and Design Strategies for Genome Editing Experiments in Zebrafish Using CRISPR/Cas9. Zebrafish. 2015 Dec 18. [Epub ahead of print] PubMed PMID: 26683213. Doudna J. Genome-editing revolution: My whirlwind year with CRISPR. Nature. 2015 Dec 24;528(7583):469-71. doi: 10.1038/528469a. PubMed PMID: 26701037.
  4. Gagnon KT, Corey DR. Stepping toward therapeutic CRISPR. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15536-7. doi: 10.1073/pnas.1521670112. Epub 2015 Dec 7. PubMed PMID: 26644585.
  5. Rahdar M, McMahon MA, Prakash TP, Swayze EE, Bennett CF, Cleveland DW. Synthetic CRISPR RNA-Cas9-guided genome editing in human cells. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7110-7. doi: 10.1073/pnas.1520883112. Epub 2015 Nov 16. PubMed PMID: 26589814.

Diseases

  1. Pankow S, Bamberger C, Calzolari D, Martínez-Bartolomé S, Lavallée-Adam M, Balch WE, Yates JR 3rd. ∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature. 2015 Dec 24;528(7583):510-6. doi: 10.1038/nature15729. Epub 2015 Nov 30. PubMed PMID: 26618866.

Imaging

  1. Barna L, Dudok B, Miczán V, Horváth A, László ZI, Katona I. Correlated confocal and super-resolution imaging by VividSTORM. Nat Protoc. 2016 Jan;11(1):163-183. doi: 10.1038/nprot.2016.002. Epub 2015 Dec 30. PubMed PMID: 26716705.
  2. Murray E, Cho JH, Goodwin D, Ku T, Swaney J, Kim SY, Choi H, Park YG, Park JY, Hubbert A, McCue M, Vassallo S, Bakh N, Frosch MP, Wedeen VJ, Seung HS, Chung K. Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems. Cell. 2015 Dec 3;163(6):1500-14. doi: 10.1016/j.cell.2015.11.025. PubMed PMID: 26638076.
  3. Errico C, Pierre J, Pezet S, Desailly Y, Lenkei Z, Couture O, Tanter M. Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging. Nature. 2015 Nov 26;527(7579):499-502. doi: 10.1038/nature16066. PubMed PMID: 26607546.

Development

  1. Camp JG, Badsha F, Florio M, Kanton S, Gerber T, Wilsch-Bräuninger M, Lewitus E, Sykes A, Hevers W, Lancaster M, Knoblich JA, Lachmann R, Pääbo S, Huttner WB, Treutlein B. Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15672-7. doi: 10.1073/pnas.1520760112. Epub 2015 Dec 7. PubMed PMID: 26644564.

				

Stem cells/ regenerative medicine

  1. Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Cao LH, Peters A, Park TS, Zambidis ET, Meyer JS, Gamm DM, Yau KW, Canto-Soler MV. Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat Commun. 2014 Jun 10;5:4047. doi: 10.1038/ncomms5047. PubMed PMID: 24915161.
  2. Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, Nandrot EF, Sahel JA, Monville C, Goureau O. From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8518-23. doi: 10.1073/pnas.1324212111. Epub 2014 May 27. PubMed PMID: 24912154.
  3. Chong JJ, Yang X, Don CW, Minami E, Liu YW, Weyers JJ, Mahoney WM, Van Biber B, Cook SM, Palpant NJ, Gantz JA, Fugate JA, Muskheli V, Gough GM, Vogel KW, Astley CA, Hotchkiss CE, Baldessari A, Pabon L, Reinecke H, Gill EA, Nelson V, Kiem HP, Laflamme MA, Murry CE. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature. 2014 Jun 12;510(7504):273-7. doi: 10.1038/nature13233. Epub 2014 Apr 30. PubMed PMID: 24776797.
  4. Normile D, Vogel G. Cell biology. STAP cells succumb to pressure. Science. 2014 Jun 13;344(6189):1215-6. doi: 10.1126/science.344.6189.1215. PubMed PMID: 24925996.

Eye diseases

  1. Agbaga MP, Tam BM, Wong JS, Yang LL, Anderson RE, Moritz OL. Mutant ELOVL4 That Causes Autosomal Dominant Stargardt-3 Macular Dystrophy Is Misrouted to Rod Outer Segment Disks. Invest Ophthalmol Vis Sci. 2014 May 15;55(6):3669-3680. doi: 10.1167/iovs.13-13099. PubMed PMID: 24833735.

Oxidative stress

  1. Moussavi Nik SH, Croft K, Mori TA, Lardelli M. The comparison of methods for measuring oxidative stress in zebrafish brains. Zebrafish. 2014 Jun;11(3):248-54. doi: 10.1089/zeb.2013.0958. Epub 2014 May 5. PubMed PMID: 24798242.

Molecular Biology

  1. Roberts JW. Molecular biology. Molecular basis of transcription pausing. Science. 2014 Jun 13;344(6189):1226-7. doi: 10.1126/science.1255712. PubMed PMID: 24926002.

Systems Biology

  1. Shalek AK, Satija R, Shuga J, Trombetta JJ, Gennert D, Lu D, Chen P, Gertner RS, Gaublomme JT, Yosef N, Schwartz S, Fowler B, Weaver S, Wang J, Wang X, Ding R, Raychowdhury R, Friedman N, Hacohen N, Park H, May AP, Regev A. Single-cell RNA-seq reveals dynamic paracrine control of cellular variation. Nature. 2014 Jun 11. doi: 10.1038/nature13437. [Epub ahead of print] PubMed PMID: 24919153.

Synthetic Biology/Gene regulatory Network

  1. Attwater J, Holliger P. A synthetic approach to abiogenesis. Nat Methods. 2014 May;11(5):495-8. doi: 10.1038/nmeth.2893. PubMed PMID: 24781322.
  2. Brophy JA, Voigt CA. Principles of genetic circuit design. Nat Methods. 2014 May;11(5):508-20. doi: 10.1038/nmeth.2926. Review. PubMed PMID: 24781324.

Behaviour

  1. Zhou Y, Cattley RT, Cario CL, Bai Q, Burton EA. Quantification of larval zebrafish motor function in multiwell plates using open-source MATLAB applications. Nat Protoc. 2014 Jul;9(7):1533-48. doi: 10.1038/nprot.2014.094. Epub 2014 Jun 5. PubMed PMID: 24901738.

Education

  1. Wieman CE. Large-scale comparison of science teaching methods sends clear message. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8319-20. doi: 10.1073/pnas.1407304111. Epub 2014 May 22. PubMed PMID: 24853505.
  2. Zhou M, Lee J. Assessing what is cultural about Asian Americans’ academic advantage. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8321-2. doi: 10.1073/pnas.1407309111. Epub 2014 May 29. PubMed PMID: 24876277.
  3. Freeman S, Eddy SL, McDonough M, Smith MK, Okoroafor N, Jordt H, Wenderoth MP. Active learning increases student performance in science, engineering, and mathematics. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8410-5. doi: 10.1073/pnas.1319030111. Epub 2014 May 12. PubMed PMID: 24821756.
  4. Hsin A, Xie Y. Explaining Asian Americans’ academic advantage over whites. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8416-21. doi: 10.1073/pnas.1406402111. Epub 2014 May 5. PubMed PMID: 24799702.

Scientific Career

  1. van Dijk D, Manor O, Carey LB. Publication metrics and success on the academic job market. Curr Biol. 2014 Jun 2;24(11):R516-7. doi: 10.1016/j.cub.2014.04.039. PubMed PMID: 24892909.

Genetics/Genomics

  1. Mali P, Esvelt KM, Church GM. Cas9 as a versatile tool for engineering biology. Nat Methods. 2013 Sep 27;10(10):957-63. doi: 10.1038/nmeth.2649. PubMed  PMID: 24076990.
  2. Esvelt KM, Mali P, Braff JL, Moosburner M, Yaung SJ, Church GM. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat Methods. 2013 Sep 29. doi: 10.1038/nmeth.2681. [Epub ahead of print] PubMed PMID: 24076762.
  3. Jao LE, Wente SR, Chen W. Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13904-9. doi: 10.1073/pnas.1308335110. Epub 2013 Aug 5. PubMed PMID: 23918387; PubMed Central PMCID: PMC3752207.
  4. Pennisi E. The CRISPR craze. Science. 2013 Aug 23;341(6148):833-6. doi: 10.1126/science.341.6148.833. PubMed PMID: 23970676.
  5. Koboldt DC, Steinberg KM, Larson DE, Wilson RK, Mardis ER. The next-generation sequencing revolution and its impact on genomics. Cell. 2013 Sep 26;155(1):27-38. doi: 10.1016/j.cell.2013.09.006. PubMed PMID: 24074859.
  6. Rivera CM, Ren B. Mapping human epigenomes. Cell. 2013 Sep 26;155(1):39-55. doi: 10.1016/j.cell.2013.09.011. PubMed PMID: 24074860.
  7. Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, Stamatoyannopoulos JA, Lettre G, Orkin SH. An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level. Science. 2013 Oct 11;342(6155):253-257. PubMed PMID: 24115442.
    • Commentary: Hardison RC, Blobel GA. GWAS to Therapy by Genome Edits? Science. 2013 Oct 11;342(6155):206-207. PubMed PMID: 24115432.

Behaviour

  1. Deeti S, O’Farrell S, Kennedy BN. Early Safety Assessment of Human Oculotoxic Drugs Using the Zebrafish Visualmotor Response. J Pharmacol Toxicol Methods. 2013 Sep 30. doi:pii: S1056-8719(13)00299-2. 10.1016/j.vascn.2013.09.002. [Epub ahead of print] PubMed PMID: 24091134.

Disease

  1. Chakravarti A, Clark AG, Mootha VK. Distilling pathophysiology from complex disease genetics. Cell. 2013 Sep 26;155(1):21-6. doi: 10.1016/j.cell.2013.09.001. PubMed PMID: 24074858.
  2. Moreno JA, Halliday M, Molloy C, Radford H, Verity N, Axten JM, Ortori CA, Willis AE, Fischer PM, Barrett DA, Mallucci GR. Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice. Sci Transl Med. 2013 Oct 9;5(206):206ra138. PubMed PMID: 24107777.

Vision

  1. Tappeiner C, Gerber S, Enzmann V, Balmer J, Jazwinska A, Tschopp M. Visual acuity and contrast sensitivity of adult zebrafish. Front Zool. 2012 May 29;9(1):10. PubMed PMID: 22643065; PubMed Central PMCID: PMC3453526.
  2. Bianco IH, Kampff AR, Engert F. Prey capture behavior evoked by simple visual stimuli in larval zebrafish. Front Syst Neurosci. 2011;5:101. doi:10.3389/fnsys.2011.00101. PubMed PMID: 22203793; PubMed Central PMCID: PMC3240898.

Development

  1. Nancy P, Tagliani E, Tay CS, Asp P, Levy DE, Erlebacher A.  Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science. 2012 Jun 8;336(6086):1317-21. PubMed PMID: 22679098.

Behaviour

  1. Polverino G, Abaid N, Kopman V, Macrì S, Porfiri M. Zebrafish response to robotic fish: preference experiments on isolated individuals and small shoals. Bioinspir Biomim. 2012 Jun 8;7(3):036019. [Epub ahead of print] PubMed PMID: 22677608.

Systems Biology

  1. Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF. Network Crosstalk Dynamically Changes during Neutrophil Polarization. Cell. 2012 May 25;149(5):1073-83. PubMed PMID: 22632971.

Human Microbiome

  1. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012 Jun 13;486(7402):207-14. doi:10.1038/nature11234. PubMed PMID: 22699609.
  2. Human Microbiome Project Consortium. A framework for human microbiome research. Nature. 2012 Jun 13;486(7402):215-21. doi: 10.1038/nature11209. PubMed PMID: 22699610.
    • Commentary: Relman DA. Microbiology: Learning about who we are. Nature. 2012 Jun 13;486(7402):194-5. doi: 10.1038/486194a. PubMed PMID: 22699602.

Retinal degeneration

  1. Taylor S, Chen J, Luo J, Hitchcock P. Light-induced photoreceptor degeneration in the retina of the zebrafish. Methods Mol Biol. 2012;884:247-54. PubMed PMID: 22688711.

Neuroscience

  1. Cyranoski D. Neuroscience: The mind reader. Nature. 2012 Jun 13;486(7402):178-80. doi: 10.1038/486178a. PubMed PMID: 22699592.
  2. Van Horn JD, Irimia A, Torgerson CM, Chambers MC, Kikinis R, Toga AW. Mapping connectivity damage in the case of phineas gage. PLoS One. 2012;7(5):e37454. Epub 2012 May 16. PubMed PMID: 22616011; PubMed Central PMCID: PMC3353935.

Retinal development

  1. Stacher Hörndli C, Chien CB. Sonic hedgehog is indirectly required for intraretinal axon pathfinding by regulating chemokine expression in the optic stalk. Development. 2012 Jun 13. [Epub ahead of print] PubMed PMID: 22696293.

 


				

Neuroimaging/ Connectomics

  1. Wedeen VJ, Rosene DL, Wang R, Dai G, Mortazavi F, Hagmann P, Kaas JH, Tseng WY. The geometric structure of the brain fiber pathways. Science. 2012 Mar 30;335(6076):1628-34. PubMed PMID: 22461612.

Neuroscience

  1. Rogulja D, Young MW. Control of sleep by cyclin A and its regulator. Science. 2012 Mar 30;335(6076):1617-21. PubMed PMID: 22461610.
  2. Koch C. Newsmaker interview: Christof Koch. A vision of how mouse vision can reveal consciousness’ secrets. Interview by Yudhijit Bhattacharjee. Science. 2012 Mar 23;335(6075):1426-7. PubMed PMID: 22442452.
  3. Morris RG, Takeuchi T. Neuroscience. The imaginary mind of a mouse. Science. 2012 Mar 23;335(6075):1455-6. PubMed PMID: 22442473.
  4. Bardin J. Neuroscience: Making connections. Nature. 2012 Mar 21;483(7390):394-6. doi: 10.1038/483394a. PubMed PMID: 22437591.

Behaviour

  1. Shohat-Ophir G, Kaun KR, Azanchi R, Heberlein U. Sexual deprivation increases ethanol intake in Drosophila. Science. 2012 Mar 16;335(6074):1351-5. PubMed PMID:22422983.
    • Commentary: Zars T. Physiology. She said no, pass me a beer. Science. 2012 Mar 16;335(6074):1309-10. PubMed PMID: 22422968.

Philosophy of Science

  1. Bodemer N, Ruggeri A. Finding a good research question, in theory. Science. 2012 Mar 23;335(6075):1439. PubMed PMID: 22442459.

Ethics, Social and Legel Issues

  1. Must try harder. Nature. 2012 Mar 28;483(7391):509. doi: 10.1038/483509a.PubMed PMID: 22460859.
  2. Begley CG, Ellis LM. Drug development: Raise standards for preclinical cancer research. Nature. 2012 Mar 28;483(7391):531-3. doi: 10.1038/483531a. PubMed PMID: 22460880.
  3. Incidental benefits. Nature. 2012 Mar 21;483(7390):373. doi: 10.1038/483373a. PubMed PMID: 22437569.
  4. Hayden EC. DNA donor rights affirmed. Nature. 2012 Mar 21;483(7390):387. doi: 10.1038/483387a. PubMed PMID: 22437587.

Systems Biology

  1. Weinstein JN. Drug discovery: Cell lines battle cancer. Nature. 2012 Mar 28;483(7391):544-5. doi: 10.1038/483544a. PubMed PMID: 22460893.
  2. Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P Jr, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T, MacConaill L, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB, Getz G, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL, Meyerson M, Golub TR, Morrissey MP, Sellers WR, Schlegel R, Garraway LA. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012 Mar 28;483(7391):603-7. doi: 10.1038/nature11003. PubMed PMID: 22460905.
  3. Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A, Lau KW, Greninger P, Thompson IR, Luo X, Soares J, Liu Q, Iorio F, Surdez D, Chen L, Milano RJ, Bignell GR, Tam AT, Davies H, Stevenson JA, Barthorpe S, Lutz SR, Kogera F, Lawrence K, McLaren-Douglas A, Mitropoulos X, Mironenko T, Thi H, Richardson L, Zhou W, Jewitt F, Zhang T, O’Brien P, Boisvert JL, Price S, Hur W, Yang W, Deng X, Butler A, Choi HG, Chang JW, Baselga J, Stamenkovic I, Engelman JA, Sharma SV, Delattre O, Saez-Rodriguez J, Gray NS, Settleman J, Futreal PA, Haber DA, Stratton MR, Ramaswamy S, McDermott U, Benes CH. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature. 2012 Mar 28;483(7391):570-5. doi: 10.1038/nature11005. PubMed PMID: 22460902.
  4. Pujadas E, Feinberg AP. Regulated noise in the epigenetic landscape of development and disease. Cell. 2012 Mar 16;148(6):1123-31. PubMed PMID: 22424224.

Eye disease

  1. Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA. A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature. 2012 Jan 11;481(7381):329-34. doi: 10.1038/nature10733. PubMed PMID: 22237022; PubMed Central PMCID: PMC3289956.

Medicine

  1. Vaidyanathan G. Redefining clinical trials: the age of personalized medicine.  Cell. 2012 Mar 16;148(6):1079-80. PubMed PMID: 22424218.

Stem cells

  1. Cherry AB, Daley GQ. Reprogramming Cellular Identity for Regenerative Medicine. Cell. 2012 Mar 16;148(6):1110-1122. Epub 2012 Mar 15. PubMed PMID: 22424223.

Career

  1. Perkel JM Ph D. Run your lab on dollars a day! Biotechniques. 2012 Mar;52(3):141-143. PubMed PMID: 22401545.
  2. Blow N Ph D. Reflections on the modern lab. Biotechniques. 2012 Mar;52(3):145-147. PubMed PMID: 22401546.

This is not a new idea, but look at this funny experiment done at Harvard. I just can’t stop wondering how much we are missing when we are staring at our experiments with our own preconception…


Most People Are Not Observant – Watch more Funny Videos