Leung Lab Blog

Genetics/Genomics

1. Mali P, Esvelt KM, Church GM. Cas9 as a versatile tool for engineering biology. Nat Methods. 2013 Sep 27;10(10):957-63. doi: 10.1038/nmeth.2649. PubMed  PMID: 24076990.
2. Esvelt KM, Mali P, Braff JL, Moosburner M, Yaung SJ, Church GM. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat Methods. 2013 Sep 29. doi: 10.1038/nmeth.2681. [Epub ahead of print] PubMed PMID: 24076762.
3. Jao LE, Wente SR, Chen W. Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13904-9. doi: 10.1073/pnas.1308335110. Epub 2013 Aug 5. PubMed PMID: 23918387; PubMed Central PMCID: PMC3752207.
4. Pennisi E. The CRISPR craze. Science. 2013 Aug 23;341(6148):833-6. doi: 10.1126/science.341.6148.833. PubMed PMID: 23970676.
5. Koboldt DC, Steinberg KM, Larson DE, Wilson RK, Mardis ER. The next-generation sequencing revolution and its impact on genomics. Cell. 2013 Sep 26;155(1):27-38. doi: 10.1016/j.cell.2013.09.006. PubMed PMID: 24074859.
6. Rivera CM, Ren B. Mapping human epigenomes. Cell. 2013 Sep 26;155(1):39-55. doi: 10.1016/j.cell.2013.09.011. PubMed PMID: 24074860.
7. Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, Stamatoyannopoulos JA, Lettre G, Orkin SH. An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level. Science. 2013 Oct 11;342(6155):253-257. PubMed PMID: 24115442.
   • Commentary: Hardison RC, Blobel GA. GWAS to Therapy by Genome Edits? Science. 2013 Oct 11;342(6155):206-207. PubMed PMID: 24115432.

Behaviour

1. Deeti S, O’Farrell S, Kennedy BN. Early Safety Assessment of Human Oculotoxic Drugs Using the Zebrafish Visualmotor Response. J Pharmacol Toxicol Methods. 2013 Sep 30. doi:pii: S1056-8719(13)00299-2. 10.1016/j.vascn.2013.09.002. [Epub ahead of print] PubMed PMID: 24091134.

Disease

1. Chakravarti A, Clark AG, Mootha VK. Distilling pathophysiology from complex disease genetics. Cell. 2013 Sep 26;155(1):21-6. doi: 10.1016/j.cell.2013.09.001. PubMed PMID: 24074858.
2. Moreno JA, Halliday M, Molloy C, Radford H, Verity N, Axten JM, Ortori CA, Willis AE, Fischer PM, Barrett DA, Mallucci GR. Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice. Sci Transl Med. 2013 Oct 9;5(206):206ra138. PubMed PMID: 24107777.
   • Commentary: Scheper W, Hoozemans JJ. A New PERKspective on Neurodegeneration. Sci Transl Med. 2013 Oct 9;5(206):206fs37. PubMed PMID: 24107775.
   • BBC News: Alzheimer’s breakthrough hailed as ‘turning point’

Vision

1. Tappeiner C, Gerber S, Enzmann V, Balmer J, Jazwinska A, Tschopp M. Visual acuity and contrast sensitivity of adult zebrafish. Front Zool. 2012 May 29;9(1):10. PubMed PMID: 22643065; PubMed Central PMCID: PMC3453526.
2. Bianco IH, Kampff AR, Engert F. Prey capture behavior evoked by simple visual stimuli in larval zebrafish. Front Syst Neurosci. 2011;5:101. doi:10.3389/fnsys.2011.00101. PubMed PMID: 22203793; PubMed Central PMCID: PMC3240898.