Archive for the ‘Fai’s sharing’ Category

On 11/12/2018, Emre Coskun attended the Purdue Fall Undergraduate Research Exposition and presented a poster of his undergraduate reserarch work on “A Pharmacological Model of TRPA1-Mediated Nociception in the Zebrafish for Therapeutic Discovery”. This project was conceived by our graduate student Logan Ganzen. Logan and Emre worked closely to develop the foundation of this research project, and established zebrafish as a model for screening drugs to alleviate pain in patients.

Emre presenting his undergraduate research work.

 

On 11/10/2018, Logan Ganzen and Yuk Fai Leung attended the 2018 Sensorium at Purdue University. Logan gave a talk on “Drug Screening and Hit Identification for Retinitis Pigmentosa with Zebrafish” and shared our latest discoveries on using zebrafish to find new drugs to treat night blindness.

Logan described how we used zebrafish model of night blindness to screen and find new drugs to treat the disease.

Logan described the therapeutic effect of a positive compound that he identified in his doctoral research.

 

ELSI

  1. Shotton D. Funders should mandate open citations. Nature. 2018 Jan 11;553(7687):129. doi: 10.1038/d41586-018-00104-7. PubMed PMID: 29323317.
  2. Lavazza A, Massimini M. Cerebral organoids: ethical issues and consciousness assessment. J Med Ethics. 2018 Feb 28. pii: medethics-2017-104555. doi: 10.1136/medethics-2017-104555. [Epub ahead of print] PubMed PMID: 29491041.

Genome Editing

  1. Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY, Liu DR. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. 2018 Jan 11;553(7687):217-221. doi: 10.1038/nature25164. Epub 2017 Dec 20. PubMed PMID: 29258297.
  2. Urnov F. An ode to gene edits that prevent deafness. Nature. 2018 Jan 11;553(7687):162-163. doi: 10.1038/d41586-017-08645-z. PubMed PMID: 29323325.

Development

  1. Nowoshilow S, Schloissnig S, Fei JF, Dahl A, Pang AWC, Pippel M, Winkler S, Hastie AR, Young G, Roscito JG, Falcon F, Knapp D, Powell S, Cruz A, Cao H, Habermann B, Hiller M, Tanaka EM, Myers EW. The axolotl genome and the evolution of key tissue formation regulators. Nature. 2018 Jan 24. doi: 10.1038/nature25458. [Epub ahead of print] PubMed PMID: 29364872.
  2. Harland RM. A new view of embryo development and regeneration. Science. 2018 Jun 1;360(6392):967-968. doi: 10.1126/science.aat8413. PubMed PMID: 29853675.
  3. Rozario T, Newmark PA. Prospecting for Planarian Pluripotency. Cell. 2018 Jun 14;173(7):1566-1567. doi: 10.1016/j.cell.2018.05.062. PubMed PMID: 29906442.
  4. Zeng A, Li H, Guo L, Gao X, McKinney S, Wang Y, Yu Z, Park J, Semerad C, Ross E, Cheng LC, Davies E, Lei K, Wang W, Perera A, Hall K, Peak A, Box A, Sánchez Alvarado A. Prospectively Isolated Tetraspanin(+) Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration. Cell. 2018 Jun 14;173(7):1593-1608.e20. doi: 10.1016/j.cell.2018.05.006. PubMed PMID: 29906446.

Stem cells

  1. Cyranoski D. How human embryonic stem cells sparked a revolution. Nature. 2018 Mar 22;555(7697):428-430. doi: 10.1038/d41586-018-03268-4. PubMed PMID: 29565377.
  2. da Cruz L, Fynes K, Georgiadis O, Kerby J, Luo YH, Ahmado A, Vernon A, Daniels JT, Nommiste B, Hasan SM, Gooljar SB, Carr AF, Vugler A, Ramsden CM, Bictash M, Fenster M, Steer J, Harbinson T, Wilbrey A, Tufail A, Feng G, Whitlock M, Robson AG, Holder GE, Sagoo MS, Loudon PT, Whiting P, Coffey PJ. Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol. 2018 Mar 19. doi: 10.1038/nbt.4114. [Epub ahead of print] PubMed PMID: 29553577.

Neuroscience

  1. Telley L, Jabaudon D. A mixed model of neuronal diversity. Nature. 2018 Mar 22;555(7697):452-454. doi: 10.1038/d41586-018-02539-4. PubMed PMID: 29565398. Science career
  2. Powell K. How to sail smoothly from academia to industry. Nature. 2018 Mar 22;555(7697):549-551. doi: 10.1038/d41586-018-03306-1. PubMed PMID: 29565380.

Microbiology

  1. Doron S, Melamed S, Ofir G, Leavitt A, Lopatina A, Keren M, Amitai G, Sorek R. Systematic discovery of antiphage defense systems in the microbial pangenome. Science. 2018 Mar 2;359(6379). pii: eaar4120. doi: 10.1126/science.aar4120. Epub 2018 Jan 25. PubMed PMID: 29371424.
  2. Pushkarev A, Inoue K, Larom S, Flores-Uribe J, Singh M, Konno M, Tomida S, Ito S, Nakamura R, Tsunoda SP, Philosof A, Sharon I, Yutin N, Koonin EV, Kandori H, Béjà O. A distinct abundant group of microbial rhodopsins discovered using functional metagenomics. Nature. 2018 Jun 20. doi: 10.1038/s41586-018-0225-9. [Epub ahead of print] PubMed PMID: 29925949.

Evolution

  1. Riddle MR, Aspiras AC, Gaudenz K, Peuß R, Sung JY, Martineau B, Peavey M, Box AC, Tabin JA, McGaugh S, Borowsky R, Tabin CJ, Rohner N. Insulin resistance in cavefish as an adaptation to a nutrient-limited environment. Nature. 2018 Mar 29;555(7698):647-651. doi: 10.1038/nature26136. Epub 2018 Mar 21. PubMed PMID: 29562229; PubMed Central PMCID: PMC5989729.

Neuroscience

  1. Weinhard L, di Bartolomei G, Bolasco G, Machado P, Schieber NL, Neniskyte U, Exiga M, Vadisiute A, Raggioli A, Schertel A, Schwab Y, Gross CT. Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction.  Nat Commun. 2018 Mar 26;9(1):1228. doi: 10.1038/s41467-018-03566-5. PubMed PMID: 29581545; PubMed Central PMCID: PMC5964317.
  2. Van Essen DC. Scaling of human brain size. Science. 2018 Jun 15;360(6394):1184-1185. doi: 10.1126/science.aat8948. PubMed PMID: 29903961.
  3. Reardon PK, Seidlitz J, Vandekar S, Liu S, Patel R, Park MTM, Alexander-Bloch A, Clasen LS, Blumenthal JD, Lalonde FM, Giedd JN, Gur RC, Gur RE, Lerch JP, Chakravarty MM, Satterthwaite TD, Shinohara RT, Raznahan A. Normative brain size variation and brain shape diversity in humans. Science. 2018 Jun 15;360(6394):1222-1227. doi: 10.1126/science.aar2578. Epub 2018 May 31. PubMed PMID: 29853553.

Genetics

  1.  Brainstorm Consortium et al., Analysis of shared heritability in common disorders of the brain. Science. 2018 Jun 22;360(6395). pii: eaap8757. doi: 10.1126/science.aap8757. PubMed PMID: 29930110.
  2. Wray NR, Wijmenga C, Sullivan PF, Yang J, Visscher PM. Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model. Cell. 2018 Jun 14;173(7):1573-1580. doi: 10.1016/j.cell.2018.05.051. Review. PubMed PMID: 29906445.

Cell Biology

  1. Ota S, Horisaki R, Kawamura Y, Ugawa M, Sato I, Hashimoto K, Kamesawa R, Setoyama K, Yamaguchi S, Fujiu K, Waki K, Noji H. Ghost cytometry. Science. 2018 Jun 15;360(6394):1246-1251. doi: 10.1126/science.aan0096. PubMed PMID: 29903975.

Signal Transduction

  1.  Capper MJ, Wacker D. How the ubiquitous GPCR receptor family selectively activates signalling pathways. Nature. 2018 Jun;558(7711):529-530. doi: 10.1038/d41586-018-05503-4. PubMed PMID: 29946098.

 

Genome-editing

  1. Niewoehner O, Garcia-Doval C, Rostøl JT, Berk C, Schwede F, Bigler L, Hall J, Marraffini LA, Jinek M. Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers. Nature. 2017 Aug 31;548(7669):543-548. doi:10.1038/nature23467. Epub 2017 Jul 19. PubMed PMID: 28722012.
  2. Johnson K, Bailey S. Microbiology: The case of the mysterious messenger. Nature. 2017 Aug 31;548(7669):527-528. doi: 10.1038/nature23532. Epub 2017 Aug 2. PubMed PMID: 28783729.
  3. Jain A, Zode G, Kasetti RB, Ran FA, Yan W, Sharma TP, Bugge K, Searby CC, Fingert JH, Zhang F, Clark AF, Sheffield VC. CRISPR-Cas9-based treatment of myocilin-associated glaucoma. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11199-11204. doi: 10.1073/pnas.1706193114. Epub 2017 Oct 2. PubMed PMID: 28973933; PubMed Central PMCID: PMC5651749.

Molecular biology

  1. García-López V, Chen F, Nilewski LG, Duret G, Aliyan A, Kolomeisky AB, Robinson JT, Wang G, Pal R, Tour JM. Molecular machines open cell membranes. Nature. 2017 Aug 30;548(7669):567-572. doi: 10.1038/nature23657. PubMed PMID: 28858304.

Development

  1. Liang J, Balachandra S, Ngo S, O’Brien LE. Feedback regulation of steady-state epithelial turnover and organ size. Nature. 2017 Aug 31;548(7669):588-591. doi: 10.1038/nature23678. Epub 2017 Aug 23. PubMed PMID: 28847000.
  2. Fernandes VM, Chen Z, Rossi AM, Zipfel J, Desplan C. Glia relay differentiation cues to coordinate neuronal development in Drosophila. Science. 2017 Sep 1;357(6354):886-891. doi: 10.1126/science.aan3174. PubMed PMID: 28860380.
  3. Boudreau-Pinsonneault C, Cayouette M. Cell lineage tracing in the retina: Could material transfer distort conclusions? Dev Dyn. 2018 Jan;247(1):10-17. doi: 10.1002/dvdy.24535. Epub 2017 Jul 13. PubMed PMID: 28643368.

Stem cells

  1. Kikuchi T, Morizane A, Doi D, Magotani H, Onoe H, Hayashi T, Mizuma H, Takara S, Takahashi R, Inoue H, Morita S, Yamamoto M, Okita K, Nakagawa M, Parmar M, Takahashi J. Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model. Nature. 2017 Aug 30;548(7669):592-596. doi: 10.1038/nature23664. PubMed PMID: 28858313.
  2. Hirota T, Ohta H, Powell BE, Mahadevaiah SK, Ojarikre OA, Saitou M, Turner JMA. Fertile offspring from sterile sex chromosome trisomic mice. Science. 2017 Sep 1;357(6354):932-935. doi: 10.1126/science.aam9046. Epub 2017 Aug 17. PubMed PMID: 28818972; PubMed Central PMCID: PMC5581950.
  3. Blanchard JW, Xie J, El-Mecharrafie N, Gross S, Lee S, Lerner RA, Baldwin KK. Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries. Nat Biotechnol. 2017 Oct;35(10):960-968. doi: 10.1038/nbt.3963. Epub 2017 Sep 11. PubMed PMID: 28892074.

Eye diseases

  1. Thorn RJ, Clift DE, Ojo O, Colwill RM, Creton R. The loss and recovery of vertebrate vision examined in microplates. PLoS One. 2017 Aug 17;12(8):e0183414. doi: 10.1371/journal.pone.0183414. eCollection 2017. PubMed PMID: 28817700; PubMed Central PMCID: PMC5560659.
  2. Jain A, Zode G, Kasetti RB, Ran FA, Yan W, Sharma TP, Bugge K, Searby CC, Fingert JH, Zhang F, Clark AF, Sheffield VC. CRISPR-Cas9-based treatment of myocilin-associated glaucoma. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11199-11204. doi: 10.1073/pnas.1706193114. Epub 2017 Oct 2. PubMed PMID: 28973933; PubMed Central PMCID: PMC5651749.

Vision

  1. Stowers JR, Hofbauer M, Bastien R, Griessner J, Higgins P, Farooqui S, Fischer RM, Nowikovsky K, Haubensak W, Couzin ID, Tessmar-Raible K, Straw AD. Virtual reality for freely moving animals. Nat Methods. 2017 Aug 21. doi: 10.1038/nmeth.4399. [Epub ahead of print] PubMed PMID: 28825703.

Education

  1. Silva HM. Intelligent design endangers education. Science. 2017 Sep 1;357(6354):880. doi: 10.1126/science.aao3245. PubMed PMID: 28860376.

Science Career

My second life as a teacher 



				

Neuroscience

  1. Robie AA, Hirokawa J, Edwards AW, Umayam LA, Lee A, Phillips ML, Card GM, Korff W, Rubin GM, Simpson JH, Reiser MB, Branson K. Mapping the Neural Substrates of Behavior. Cell. 2017 Jul 13;170(2):393-406.e28. doi: 10.1016/j.cell.2017.06.032. PubMed PMID: 28709004.
  2. Smith K. How to map the circuits that define us. Nature. 2017 Aug 9;548(7666):150-152. doi: 10.1038/548150a. PubMed PMID: 28796220.

Evolution

  1. Sousa AMM, Meyer KA, Santpere G, Gulden FO, Sestan N. Evolution of the Human Nervous System Function, Structure, and Development. Cell. 2017 Jul 13;170(2):226-247. doi: 10.1016/j.cell.2017.06.036. Review. PubMed PMID: 28708995.

Genetics

  1. New concerns raised over value of genome-wide disease studies

Cell biology

  1. Biology of single cells shines a light on collaboration. Nature. 2017 Jul 5;547(7661):5. doi: 10.1038/547005a. PubMed PMID: 28682351.

Genomics

  1. Nagano T, Lubling Y, Várnai C, Dudley C, Leung W, Baran Y, Mendelson Cohen N, Wingett S, Fraser P, Tanay A. Cell-cycle dynamics of chromosomal organization at single-cell resolution. Nature. 2017 Jul 5;547(7661):61-67. doi: 10.1038/nature23001. PubMed PMID: 28682332.

Molecular Biology

  1. Lin YL, Pasero P. Transcription-Replication Conflicts: Orientation Matters. Cell. 2017 Aug 10;170(4):603-604. doi: 10.1016/j.cell.2017.07.040. PubMed PMID: 28802036.

Genome editing

  1. Ma H, Marti-Gutierrez N, Park SW, Wu J, Lee Y, Suzuki K, Koski A, Ji D, Hayama T, Ahmed R, Darby H, Van Dyken C, Li Y, Kang E, Park AR, Kim D, Kim ST, Gong J, Gu Y, Xu X, Battaglia D, Krieg SA, Lee DM, Wu DH, Wolf DP, Heitner SB, Belmonte JCI, Amato P, Kim JS, Kaul S, Mitalipov S. Correction of a pathogenic gene mutation in human embryos. Nature. 2017 Aug 2. doi: 10.1038/nature23305. [Epub ahead of print] PubMed PMID: 28783728.

Genome editing

  1. Scheufele DA, Xenos MA, Howell EL, Rose KM, Brossard D, Hardy BW. U.S. attitudes on human genome editing. Science. 2017 Aug 11;357(6351):553-554. doi: 10.1126/science.aan3708. PubMed PMID: 28798120.
  2. Amitai G, Sorek R. Intracellular signaling in CRISPR-Cas defense. Science. 2017 Aug 11;357(6351):550-551. doi: 10.1126/science.aao2210. PubMed PMID: 28798118.
  3. Kazlauskiene M, Kostiuk G, Venclovas Č, Tamulaitis G, Siksnys V. A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems. Science. 2017 Aug 11;357(6351):605-609. doi: 10.1126/science.aao0100. Epub 2017 Jun 29. PubMed PMID: 28663439.

Eye

  1. Madl T. Patchy proteins form a perfect lens. Science. 2017 Aug 11;357(6351):546-547. doi: 10.1126/science.aao1456. PubMed PMID: 28798115.
  2. Cai J, Townsend JP, Dodson TC, Heiney PA, Sweeney AM. Eye patches: Protein assembly of index-gradient squid lenses. Science. 2017 Aug 11;357(6351):564-569. doi: 10.1126/science.aal2674. PubMed PMID: 28798124.

Funding

  1. Levitt M, Levitt JM. Future of fundamental discovery in US biomedical research. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6498-6503. doi: 10.1073/pnas.1609996114. Epub 2017 Jun 5. PubMed PMID: 28584129; PubMed Central PMCID: PMC5488913.

Yuk Fai Leung participated in the 2017 Developmental Biology Teaching Workshop (DBTW) from 27th June 2017 to 1st July 2017. This workshop was organized by Jennifer Fish from U Mass Lowell, Ian Woods from Ithaca College, and Eric Cole from St. Olaf College. It took place at the Darling Marine Center in Maine.

During this course, the participants studied many animal models for development including sea urchins, zebrafish, chicken, roundworm, flatworm and fruit flies. We focused on learning experiments that can be brought to the teaching lab to enrich student’s learning experience. Here are some pictures of the event:

The Developmental Biology Teaching Workshop, class of 2017.

Course leader Jennifer Fish

Course leader Ian Woods demonstrating zebrafish research.

Guest Instructor Eric Cole

The workshop took place at the beautiful Darling Marine Center.

Fai injected zebrafish embryos free hand with mouth pipetting.

Zebrafish with improper posterior development. Courtesy of 2017 DBTW.

An abnormal fruit fly made by the following transgenic line: dpp-GAL4; UAS-ey. Courtesy of 2017 DBTW.

Neurons in fruit fly larva labelled by green fluorescent protein. Courtesy of 2017 DBTW.

Sea Urchin Larva. Courtesy of 2017 DBTW.

Sea urchin larva 2. Courtesy of 2017 DBTW.

Roundworm. Nuclei labelled by a blue fluorescent dye. Courtesy of 2017 DBTW.

We finished the course with the final animal model–delicious lobsters from Maine!

In May 2017, the Leung lab visited several collaborating groups in Asia and shared with them our research vision on using zebrafish to find new drugs for retinal degeneration. In this blog post, we will share some pictures of our visit to the the Eye Hospital at Wenzhou Medical University in China. We were hosted by Dr. Zibing Jin, a very accomplished vision scientist. We visited the University campus, and the eye hospital. Logan and Fai presented their work and interacted with the local students. Fai was also invited to be the external examiner of six master students and attended their oral defence. We also visit Yandang Mountains, a famous national geological park in China.

Wenzhou Medical University has a very pretty main campus in Chashan, with nice open space for the students.

Main campus of Wenzhou Medical University in Chashan

They have a whole building of 14 floors dedicated for different aspects of eye research!

Dr. Zibing Jin explaining the research programs in the Eye Hospital at Wenzhou Medical University.

Dr. Zibing Jin’s research group is accomplishing very well in recent years. They study genetics, stem cells, and animal models including zebrafish! In 2017 spring, they published three articles in the Proceedings of the National Academy of Sciences, one of the most influential journals in the world.

Dr Zibing Jin sharing his group’s research achievements to Logan and Fai

The Leung lab has been working with Dr. Jin’s group for years. During this trip, Fai outlined his research vision; whereas Logan presented his recent findings to the students.

Fai outlined his research vision to the students at Wenzhou Medical University.

Logan presented his latest findings to the students at Wenzhou Medical University.

Dr. Jin invited Fai to be an external examiner of six master students, whom had their oral defence during our visit. All these students had an extremely positive attitude and were very prolific! They all publish their work in international journals as first author, and contributed to many other lab projects as co-author.

Fai as external examiner of six master students’ oral defence at Wenzhou Medical University.

(Front row) Fai and four other external examiners. (Back row) Dr. Jin and six of his master students.

Enjoying local cuisine with colleagues.

Fai and Logan also visited Yandang Mountains, a famous national geological park in China, with several colleagues.

Logan, Fai and colleagues at Yandang mountains.

Logan and Fai at Yandang mountains. The  Chinese characters on the monument are literally “Yandang mountains”.

In May 2017, the Leung lab visited several collaborating groups in Asia and shared with them our research vision on using zebrafish to find new drugs for retinal degeneration. In this blog post, we will share some pictures of our visit to the Department of Ophthalmology and Visual Sciences (DOVS) at the Chinese University of Hong Kong in the next paragraph. We will also share some pictures of our attendance of the International Conference of Vision & Eye Research at the end of this post.

In DOVS, Dr. Wai Kit Chu from this department and Fai organized a “CUHK Ophthalmic Research Centre Joint Symposium” and invited local experts in ophthalmology and neuroscience to share our latest research findings with each other. Fai outlined our lab’s research program on discover new drugs for retinal degeneration by zebrafish research. Logan presented a talk entitled “Visual Motor Response of a Transgenic Retinitis Pigmentosa Zebrafish Model”.

The CUHK Ophthalmic Research Centre Joint Symposium.
From left to right, 1st row: Mr Jeremiah Palmerston, Dr Wai Kit Chu, Dr Yuk Fai Leung and Mr Logan Ganzen.
From left to right, 2nd row: Dr Rosa Chan, Dr Geoffrey Lau, Dr Wenjun Xiong and Dr Amy Lo.

Fai outlined our lab’s research program on discover new drugs for retinal degeneration by zebrafish research.

Logan presented a talk entitled “Visual Motor Response of a Transgenic Retinitis Pigmentosa Zebrafish Model”.

Dr. Amy Lo from the Department of Ophthalmology at the University of Hong Kong.

Dr. Geoffrey Lau from the Department of Biomedical Sciences at the City University of Hong Kong.

Dr. Wai Kit Chu from the Department of Ophthalmology and Visual Sciences at the Chinese University of Hong Kong.

Dr. Wenjun Xiong from the Department of Biomedical Sciences at the City University of Hong Kong

Dr. Rosa Chan from the Department of Electronic Engineering at the City University of Hong Kong.

Jeremiah Palmerston from Dr. Rosa Chan’s group.

Fai and Logan also attended the International Conference of Vision & Eye Research (iCOVER) when they were in Hong Kong.

Fai and Logan with Dr. Chi Wai Do from the School of Optometry at the Hong Kong Polytechnic University and Dr. Amy Lo from the Department of Ophthalmology at the University of Hong Kong during the dinner ceremony of iCOVER.

Logan and Fai with Dr. Henry Chan from the School of Optometry at the Hong Kong Polytechnic University during the coffee break of iCOVER.

 

Development

  1. Kobayashi T, Zhang H, Tang WWC, Irie N, Withey S, Klisch D, Sybirna A, Dietmann S, Contreras DA, Webb R, Allegrucci C, Alberio R, Surani MA. Principles of early human development and germ cell program from conserved model systems. Nature. 2017 Jun 7. doi: 10.1038/nature22812. [Epub ahead of print] PubMed PMID: 28607482.
  2. Peter IS, Davidson EH. Assessing regulatory information in developmental gene regulatory networks. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):5862-5869. doi: 10.1073/pnas.1610616114. PubMed PMID: 28584110.

Regeneration

  1. Laha B, Stafford BK, Huberman AD. Regenerating optic pathways from the eye to the brain. Science. 2017 Jun 9;356(6342):1031-1034. doi: 10.1126/science.aal5060. Review. PubMed PMID: 28596336.

Genomics

  1. Jiao Y, Peluso P, Shi J, Liang T, Stitzer MC, Wang B, Campbell MS, Stein JC, Wei X, Chin CS, Guill K, Regulski M, Kumari S, Olson A, Gent J, Schneider KL, Wolfgruber TK, May MR, Springer NM, Antoniou E, McCombie WR, Presting GG, McMullen M, Ross-Ibarra J, Dawe RK, Hastie A, Rank DR, Ware D. Improved maize reference genome with single-molecule technologies. Nature. 2017 Jun 12. doi: 10.1038/nature22971. [Epub ahead of print] PubMed PMID: 28605751.

Stem cells

  1. Kilpinen H, Goncalves A, Leha A, Afzal V, Alasoo K, Ashford S, Bala S, Bensaddek D, Casale FP, Culley OJ, Danecek P, Faulconbridge A, Harrison PW, Kathuria A, McCarthy D, McCarthy SA, Meleckyte R, Memari Y, Moens N, Soares F, Mann A, Streeter I, Agu CA, Alderton A, Nelson R, Harper S, Patel M, White A, Patel SR, Clarke L, Halai R, Kirton CM, Kolb-Kokocinski A, Beales P, Birney E, Danovi D, Lamond AI, Ouwehand WH, Vallier L, Watt FM, Durbin R, Stegle O, Gaffney DJ. Common genetic variation drives molecular heterogeneity in human iPSCs. Nature. 2017 May 10. doi: 10.1038/nature22403. [Epub ahead of print] PubMed PMID: 28489815.

Genome Editing

  1. Dong, Guo M, Wang S, Zhu Y, Wang S, Xiong Z, Yang J, Xu Z, Huang Z. Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein. Nature. 2017 Apr 27. doi: 10.1038/nature22377. [Epub ahead of print] PubMed PMID: 28448066.

Molecular Biology

  1. Pennisi E. Circular DNA throws biologists for a loop. Science. 2017 Jun 9;356(6342):996. doi: 10.1126/science.356.6342.996. PubMed PMID: 28596318.
  2. Roundtree IA, Evans ME, Pan T, He C. Dynamic RNA Modifications in Gene Expression Regulation. Cell. 2017 Jun 15;169(7):1187-1200. doi: 10.1016/j.cell.2017.05.045. Review. PubMed PMID: 28622506.

Funding

  1. Kaiser J. Data Check: Critics challenge NIH finding that bigger labs aren’t necessarily better. Science. 2017 Jun 9;356(6342):997. doi: 10.1126/science.356.6342.997. PubMed PMID: 28596319.

Genetics

  1. Boyle EA, Li YI, Pritchard JK. An Expanded View of Complex Traits: From Polygenic to Omnigenic. Cell. 2017 Jun 15;169(7):1177-1186. doi: 10.1016/j.cell.2017.05.038. Review. PubMed PMID: 28622505.
  2. Trigos AS, Pearson RB, Papenfuss AT, Goode DL. Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6406-6411. doi: 10.1073/pnas.1617743114. Epub 2017 May 8. PubMed PMID: 28484005.
  3. Bussey KJ, Cisneros LH, Lineweaver CH, Davies PCW. Ancestral gene regulatory networks drive cancer. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6160-6162. doi: 10.1073/pnas.1706990114. Epub 2017 Jun 5. PubMed PMID: 28584134.

Evolution

  1. Cindrova-Davies T, Jauniaux E, Elliot MG, Gong S, Burton GJ, Charnock-Jones DS. RNA-seq reveals conservation of function among the yolk sacs of human, mouse, and chicken. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4753-E4761. doi: 10.1073/pnas.1702560114. Epub 2017 May 30. PubMed PMID: 28559354.

 

In May 2017, the Leung lab visited several collaborating groups in Asia and shared with them our research vision on using zebrafish to find new drugs for retinal degeneration. In this blog post, we will share some pictures of our visit to the Department of Ophthalmology at the Osaka University School of Medicine. We met our long-term collaborator Dr. Motokazu Tsujikawa. He is a co-mentor of Logan Ganzen, a graduate student in our laboratory. Logan is a recipient of the predoctoral award from the Indiana Clinical and Translational Sciences Institute. During our Osaka trip, he presented a talk entitled “Visual Motor Response of a Transgenic Retinitis Pigmentosa Zebrafish Model” to Dr. Tsujikawa.

 

Logan in front of a new Center for Medical Innovation and Translational Research.

Fai and Dr. Motokazu in his zebrafish facility in the Center of Medical Innovation and Translational Research.

The Center is beautifully designed with lots of open space.

Logan presented his latest findings to Dr. Motokazu, who served as a co-mentor in Logan’s CTSI predoctoral fellowship.

We also visited the daily operation of the ophthalmology clinic and Osaka University Hospital, and participated in the grand rounds of the local ophthalmologists. We experienced firsthand the passion of translational research from our Japanese colleagues.

Entrance hall of the medical building

A panoramic view at the top floor of the hospital.

We joined the grand rounds of the local ophthalmologists. Dr. Kohji Nishida welcomed the group and gave an opening speech.  Even though we did not speak Japanese, we witnessed their passion to improve clinical service through research.

Needless to say, we were also well-fed by Dr. Tsujikawa with the finest Japanese food, and took some time to visit Kyoto, a magnificent ancient city.

Dr. Motokazu fed us with delicious Japanese food!

A torii path at the Fushimi Inari Taisha in Kyoto.

Kinkaku-ji in Kyoto