Andrew Mesecar Publications


Hu, C., Eggler, A. L., Mesecar, A. D., van Breemen, R. B.,  . 2011. "Modification of Keap1 cyseine residues by sulforaphane". Chem Res Toxicol. 24: 515-521.

Small, E., Eggler, A., Mesecar, A. D. 2010. "Development of efficient E. coli expression and purification system for a catalytically active, human Cullin3-RINGBox1 protein complex and elucidation of its quaternary structure with Deap1". Biochem Bio;hys Res Commun. 400: 471-475.

Eggler, A. L., Small, E., Hannink, M., Mesecar, A. D. 2009. "Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1". Biochem J. 422: 171-180.

McAdams, K., Casper, E. S., Matthew Haas, R., Santarsiero, B. D., Eggler, A. L., Mesecar, A., Halkides, C. J. 2008. "The structures of T87l phosphono-DheY and T87l/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides". Arch Biochem Biophys. 479: 105-113.

Holland, R., Hawkins, A. E., Eggler, A. L., Mesecar, A. D., Fabris, D., Fishbein, J. C. 2008. "Prospective type 1 and type 2 disulfides of Keap1 protein". Chem Res Toxicol. 21: 2051-2060.

Eggler, A. L., Gay, K. A., Mesecar, A. D. 2008. "Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2". Mol Nutr Food Res. 52: S84-94.

Luo, Y., Eggler, A. L., Liu, D., Liu, G., Mesecar, A. D., van Breemen, R. B. 2007. "Sites of alkylation of human Keap1 by natural chemoprevention agents". J Am soc mass Spectrom. 18: 2226-2232.

Eggler, A. L., Luo, Y., van Breemen, R. B., Mesecar, A. D. 2007. "Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent". Chem Res Toxicol. 20: 1878-1884.

Liu, G., Eggler, A. L., Dietz, B. M., Mesecar, A. D., Bolton, J. L., Pezzuto, J. M., van Breemen, R. B. 2005. "Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1". Anal Chem. 77: 6407-6414.

Eggler, A. L., Liu, G., Pezzuto, J. M., van Breemen, R. B., Mesecar, A. D. 2005. "Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2". Proc Natl Acad Sci USA. 102: 10070-10075.

Dietz, B. M., Kang, Y. H., Liu, G., Eggler, A. L., Yao, P., Chawick, L. R., Pauli, G. G., Farnsworth, N. R., Mesecar, A. D., van Breemen, R. B., Bolton, J. L. 2005. "Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase". Chem Res Toxicol. 18: 1296-1305.


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