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Yuk Fai Leung Publications


Liu Y, Ma P, Cassidy PA, Carmer R, Zhang G, Venkatraman P, Brown SA, Pang CP, Zhong W, Zhang M, Leung YF. Statistical Analysis of Zebrafish Locomotor Behaviour by Generalized Linear Mixed Models. Sci Rep. 2017 Jun 7;7(1):2937.

Ganzen L, Venkatraman P, Pang CP, Leung YF*, Zhang M*. Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration. Int J Mol Sci. 2017 Jun 2;18(6). pii: E1185. (*co-corresponding authors)

Zhang LY, Zhang X, Zhang G, Pang CP, Leung YF*, Zhang M*, Zhong W*. Expression profiling of the retina of pde6c, a zebrafish model of retinal degeneration. Sci Data. 2017. In press. (*co-corresponding authors)

Hensley MR, Chua RF, Leung YF, Yang JY, Zhang G. Molecular Evolution of MDM1, a "Duplication-Resistant" Gene in Vertebrates. PLoS One. 2016 Sep 22;11(9):e0163229.

Weaver CJ, Leung YF, Suter DM. Expression dynamics of NADPH oxidases during early zebrafish development. 2016 Jul 1;524(10):2130-41

Hensley M, Cui Z, Chua R, Simpson S, Shammas N, Yang JY, Leung YF, Zhang GJ. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Sci Rep. 2016 Jun 13;6:27816.

Zhang L, Xiang L, Liu Y, Venkatraman P, Chong L, Cho J, Bonilla S, Jin ZB, Pang CP, Ko KM, Ma P, Zhang M, Leung YF. A naturally-derived compound Schisandrin B enhanced light sensation in the pde6c zebrafish model of retinal degeneration. PLoS One. 2016 Mar 1;11(3):e0149663.

Gao Y, Zhang G, Jelfs B, Carmer R, Venkatraman P, Ghadami M, Brown SA, Pang CP, Leung YF*, Chan RHM*, Zhang M*. Computational classification of different wild-type zebrafish strains based on their variation in light-induced locomotor response. Comput Biol Med. 2016 Feb 1;69:1-9. (*co-corresponding authors)

Liu Y, Carmer R, Zhang G, Venkatraman P, Brown SA, Pang CP, Zhang M, Ma P, Leung YF. Statistical analysis of zebrafish locomotor response. PLOS ONE. 2015; 10: e0139521.

Bishop B, Ho KK, Tyler K, Smith A, Bonilla S, Leung YF, Ogas J. The chromatin remodeler chd5 is necessary for proper head development during embryogenesis of Danio rerio. Biochim Biophys Acta. 2015;1849:1040-1050.

Gao Y, Chan RHM, Chow TWS, Zhang L, Bonilla S, Pang CP, Zhang M, Leung YF. A High-Throughput Zebrafish Screening Method for Visual Mutants by Light-Induced Locomotor Response. IEEE/ACM Trans Comput Biol Bioinform. 2014; 11:693-701.

Zhang L, Bonilla S, Zhang Y, Leung YF. p35 promotes the differentiation of amacrine cell subtype in the zebrafish retina under the regulation of egr1. Dev Dyn. 2014; 243:315-23.

Zhang L, Ma P, Collery R, Trowbridge S, Zhang M, Zhong W, Leung YF. Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation. Mol Vis. 2014; 20:56-72.

Li Z, Zhang L, Leung YF. Use of the zebrafish model to study refractive errors. Expert Rev Ophthalmol. 2013; 8:1-3.

Zhang Y, Bonilla S, Chong L, Leung YF. Irx7, a Smarca4-regulated gene for retinal differentiation, regulates other genes controlled by Smarca4 in zebrafish retinas. Gene Expr Patterns. 2013;13:177-82. 

Zhang L, Cho J, Ptak D, Leung YF. The role of egr1 in early zebrafish retinogenesis. PLOS ONE. 2013; 8:e56108.

Zhang L, Chong L, Cho J, Liao PC, Shen F, Leung YF. Drug Screening to Treat Early-Onset Eye Diseases: Can Zebrafish Expedite the Discovery? Asia-Pac J Ophthalmol 2012; 1:374-383.

Li Z, Ptak D, Zhang L, Walls EK, Zhong W, Leung YF. Phenylthiourea specifically reduces zebrafish eye size. PLoS ONE. 2012;7:e40132.

Zhang Y, Yang YF, Trujillo CM, Zhong W, Leung YF. The expression of irx7 in the inner nuclear layer of zebrafish retina is essential for a proper development of both inner and outer nuclear layers and formation of retinal lamination. PLoS ONE. 2012;7(4): e36145.

Hensley MR, Hassenplug E, McPhail R, Leung YF. ZeBase: An open-source relational database for zebrafish laboratories. Zebrafish. 2012;9(1):44-9.

Hensley MR, Emran F, Bonilla S, Grosu P, Zhang L, Dowling JE, Leung YF. Cellular Expression of Brg1-regulated Retinal Differentiation Genes in Wild-type And Mutant Young Retinas. BMC Dev Biol. 2011;11:45. 

Zhang L, Leung YF. Microdissection of Zebrafish Embryonic Eye Tissues. J. Vis. Exp. 2010; 40. pii: 2028.

Hensley MR, Leung YF. A Convenient Dry Feed for Raising Zebrafish Larvae. Zebrafish. 2010; 7:219-31.

Leung YF, Ma P, Link BA, Dowling JE. Factorial Microarray Analysis of Zebrafish Retinal Development. Proc Natl Acad Sci U S A. 2008; 105:12909-14.

Leung YF, Ma P, Dowling JE. Gene Expression Profiling of Zebrafish Embryonic Retinal Pigment Epithelium in vivo. Invest Ophthalmol Vis Sci. 2007;48:881-890.

Leung YF, Dowling JE. Gene Expression Profiling of Zebrafish Embryonic Retina. Zebrafish. 2005; 4:269-283.

Fan BJ, Leung YF, Pang CP, Wang DY, Tong WC, Tam POS, Chua JKH, Lau TC, Lam DSC. Polymorphisms in the MYOC promoter unrelated to the risk and severity of primary open angle glaucoma. J Glaucoma. 2004; 13:377-384.

Fan BJ, Leung YF, Wang N, Lam SC, Liu Y, Tam OS, Pang CP. Genetic and environmental risk factors for primary open-angle glaucoma. Chin Med J (Engl). 2004; 117:706-710.

Fan BJ, Leung YF, Pang CP, Baum L, Tam OS, Wang N, Lam DSC. Single nucleotide polymorphism of the myocilin gene in primary open-angle glaucoma patients. Chin J Med Genet. 2004; 21:70-73.

Leung YF, Cavalieri D. Fundamentals of cDNA microarray analysis. Trends Genet. 2003; 19:649-659.

Leung YF, Tam PO, Lee WS, Lam DS, Yam HF, Fan BJ, Tham CC, Chua JK, Pang CP. The dual role of dexamethasone on anti-inflammation and outflow resistance demonstrated in cultured human trabecular meshwork cells. Mol Vis. 2003; 9:425-439.

Leung YF, Fan BJ, Lam DSC, Lee WS, Tam POS, Chua JKH, Tham CCY, Lai JSM, Fan DSP, Pang CP. Different Optineurin Mutation Pattern in Chinese Primary Open Angle Glaucoma Patients. Invest Ophthalmol Vis Sci. 2003; 44:3880-3884.

Lam DSC, Lee WS, Leung YF, Tam POS, Fan DSP, Fan BJ, Pang CP. TGFB-induced factor (TGIF) – a candidate gene for high myopia. Invest Ophthalmol Vis Sci. 2003; 44:1012-1015.

Lam DSC, Tam POS, Fan DSP, Baum L, Leung YF, Pang CP. Familial high myopia linkage to chromosome 18p. Ophthalmologica. 2003; 217:115-118.

Leung YF, Pang CP. Eye on bioinformatics - dissecting complex disease trait in silico. Applied Bioinformatics. 2002; 1:69-80.

Leung YF, Pang CP, Lam DSC. Microarray software review. In: A practical approach to microarray data analysis. D.P. Berrar, W. Dubitzky and M. Granzow, (Eds.), Kluwer academic, 2002.

Pang CP, Leung YF, Fan BJ, Baum L, Tong WC, Lee WS, Chua JKH, Fan DSP, Liu Y, Lam DSC. TIGR/MYOC Gene Sequence Alterations in Individuals with and without Primary Open Angle Glaucoma. Invest Ophthalmol Vis Sci. 2002; 43:3231-3235.

Wang N, Peng Z, Fan B, Liu Y, Dong X, Leung YF, Luan J. Case control study on the risk factors of primary open angle glaucoma in China. Chin J Epidemiol. 2002; 23:293-296.

Fan BJ, Leung YF, Pang CP, Dong XM, Liu Y, Luan J, Wang N. Study on single nucleotide polymorphism of TIGR gene in primary open-angle glaucoma patients. Natl Med J China. 2002; 82:743-747.

Leung YF, Tam POS, Tong WC, Choy KW, Lam DSC, Pang CP. High throughput conformation sensitive gel electrophoresis (HTCSGE) for rapid detection of novel single nucleotide polymorphisms (SNPs). Biotechniques. 2001; 30:334-340.

Leung YF, Tam POS, Baum L, Lam DSC, Pang CP. TIGR proximal promoter GT-repeat polymorphism not associated with myopia. Hum Mutat 2000; 16:533.

Leung YF, Baum L, Lam DSC, Fan DSP, Chua JKH, Pang CP. Absence of trabecular meshwork inducible stretch response (TISR)/oculomedin gene and proximal promoter mutation in primary open angle glaucoma patients. Hum Genet. 2000; 107:404-5.

Leung YF, Tam POS, Baum L, Chan WM, Lam DSC, Pang CP. Cost Savings Using Automated DNA Sequencing. Biotechniques. 2000; 29:544. 

Lam DSC, Leung YF, Chua JKH, Baum L, Fan DS, Choy KW, Pang CP. Truncations in the TIGR gene in individuals with and without primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2000; 41:1386-1391.

Pang CP, Leung YF, Chua JKH, Baum L, Fan DSP, Lam DSC. Novel TIGR sequence alteration Val53Ala. Hum Mutat 2000; 15:122.

Baum L, Pang CP, Fan DSP, Poon PMK, Leung YF, Chua JKH, Lam DSC. Run-on mutation and three novel nonsense mutations identified in the PAX6 gene in patients with aniridia. Hum Mutat 1999; 14:231-232.


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