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R. Claudio Aguilar Publications


Hsieh, W.-C., Ramadesikan, S., Fekete, D., Aguilar, R. C. 2018. Kidney-differentiated cells derived from Lowe Syndrome patient's iPSCs show ciliogenesis defects and Six2 retention at the Golgi complex. PLoS ONE 13:e0192635.

Sen, A., Hsieh, W.-C., Aguilar, R. C. 2017. The information content of glutamine-rich sequences define protein functional characteristics. Proc of the IEEE. 105:385-393. 

Furmento, V. A., Marino, J., Blank, V. C., Cayrol, M. F., Cremaschi, G. A., Aguilar, R. C., Roguin, L. P. 2016. Granulocyte colony-stimulating factor (G-CSF) upregulates β1 integrin and increases migration of human trophoblast Swan 71 cells via PI3K and MAPK activation. Exp Cell Res. 342:125-134.

Madhivanan, K., Ramadesikan, S., Aguilar, R. C. 2016. Role of Ocrl1 and Inpp5E in primary cilia assembly and maintenance: a phosphatidylinositol phosphatase relay system? Res Rep Biol. 7:15-29.

Aguilar, R. C. 2015. Introduction to the Analysis of the Intracelluar Sorting Information in Protein Sequences: From Molecular Biology to Artificial Neural Networks. Methods Mol Biol. 1260:1-16.

Furmento, V. A., Blank, V. C., Madhivanan, K., Aguilar, R. C., Marino, V. J., and Roguin, L. P. 2015. MAPKs and PI3K/Atk pathways are involved in G-CSF-induced migration in a human trophoblast cell line. Placenta 34(4):488.

Madhivanan, K. and Aguilar, R. C. 2014. Ciliopathies: the trafficking connection. Traffic (Copehagen, Denmark) 15(10):1031-1056.

Madhivanan, K., Ramadadesikan, S., Aguilar, R. C. 2015. Role of Ocrl1 in Primary Cilia Assembly. In International Review of Cell and Molecular Biology, Kwang, W. J., Ed. Academic Press. 317:331-347.

Mukherjee, D., Sen, A., Aguilar, R. C. 2014. RhoGTPase-binding proteins, the exocyst complex and polarized vesicle trafficking. Small GTPases 5:e28453.

Sen, A., Mukherjee, D., Aguilar, R. C. 2013. Bem3: Filling the GAP between cell polarity and secretion. Commun Integr Biol. 6:e26702.

Mukherjee, D., Sen, A., Boettner, D. R., Fairn, G. D., Schlam, D., Bonilla Valentin, F. J., McCaffery, J. M., Hazbun, T., Staiger, C. J., Grinstein, S., Lemmon, S. K., Aguilar, R. C. 2013. Bem3, a Cdc42 GTPase-activating protein, traffics to an intracellular compartment and recruits the secretory Rab GTPase Sec4 to endomembranes. J Cell Sci. 126:4560-4571.

Costakes, G. T., Sen, A., Aguilar, R. C., Sauffacher, C. V. 2013. Crystallographic analysis of the ENTH domain from yeast epsin Ent2 that induces a cell division phenotype. Protein Sci. 22:755-761.

Madhivanan, K., Mukherjee, D., Aguilar, R. C. 2012. Lowe syndrome: Between primary cilia assembly and Rac1-mediated membrane remodeling. Commun Integr Biol. 5:641-644.

Coon, B. G., Crist, S., González-Bonet, A. M., Kim, H.-K., Sowa, J., Thompson, D. H., Ratliff, T. L., Aguilar, R. C. 2012. Fibronectin attachment protein from bacillus Calmette-Guerin as targeting agent for bladder tumor cells. Int J Cancer. 131:591-600.

Coon, B. G., Hernandez, V., Madhivanan, K., Mukherjee, D., Hanna, C. B., Barinaga-Rementeria Ramirez, I., Lowe, M., Beales, P. L., Aguilar, R. C. 2012. The Lowe syndrome protein OCRL1 is involved in primary cilia assembly. Hum Mol Genet. 21:1835-1847.

Sen, A., Madhivanan, K., Mukherjee, D., Aguilar, R. C. 2012. The epsin protein family: coordinators of endocytosis and signaling. Biomol Concepts 3:117-126.

Mukherjee, D., Hanna, C. B., Aguilar, R. C. 2012. Artificial neural network for the prediction of tyrosine-based sorting signal recognition by adaptor complexes. J Biomed Biotechnol. 2012:498031.

Coon, B. G., DiRenzo, D. M., Konieczny, S. F., Aguilar, R. C. 2011. Epsins novel role in cancer cell invasion. Commun Integr Biol. 4: 95-97.

Mukherjee, D., Sen, A., Aguilar, R. C. 2010. Analysis of the development of a morphological phenotype as a function of protein concentration in budding yeast. J Vis Exp. 37: 1863. doi: 10.3791/1863.

Minnikanti, S., Reyese, D. R., Aguilar, R. C., Pancrazio, J. J., Gaitan, M., Peixoto, N. 2010. Microfluidic based contactless dielectrophoretic device: Modeling and analysis. Conf Proc IEEE Eng Med Biol Soc. 6506-6509.

Coon, B. G., Burgner, J., Camonis, J. H., Aguilar, R. C. 2010.
The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasion. J Biol Chem. 285: 33073-33081.

Coon, B.G., Mukherjee, D., Hanna, C.B., Riese II, D.J., Lowe, M., Aguilar, R.C. 2009. Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase. Hum Mol Genet. 18: 4478-4491.

Mukherjee, D., Coon, B. G., Edwards III, D. F., Hanna, C. B., Longhi, S. A., McCaffery, J. M., Wendland, B., Retegui, L. A., Bi, E., Aguilar, R. C. 2009. The yeast endocytic protein Epsin-2 (Ent2) functions in a conserved cell division signaling pathway. J Cell Sci. 122: 2453-2463.

Aguilar, R. C., Longhi, S. A., Shaw, J. D., Yeh, L-Y., Kim, S., Schön, A., Freire, E., Hsu, A., McCormick, W. K., Watson, H. A., Wendland, B. 2006. Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins. Proc Natl Acad Sci U S A. 103: 4116-4121.

Aguilar, R. C., Wendland, B. 2005. Endocytosis of membrane receptors: two pathways are better than one. Proc Natl Acad Sci U S A. 102: 2679-2680.

Arighi, C. N., Hartnell, L. M., Aguilar, R. C., Haft, C. R., Bonifacino, J. S. 2004. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol. 165: 123-133.

Aguilar, R. C., Watson, H. A., Wendland, B. 2003. The yeast Epsin Ent1 is recruited to membranes through multiple independent interactions. J Biol Chem. 278: 10737-10743.

Aguilar, R. C., Wendland, B. 2003. Ubiquitin: not just for proteasomes anymore. Curr Opin Cell Biol. 15: 184-190.

Aguilar, R. C., Boehm, M., Gorshkova, I., Crouch, R. J., Tomita, K., Saito, T., Ohno, H., Bonifacino, J. S. 2001. Signal-binding specificity of the μ4 subunit of the adaptor protein complex AP-4. J Biol Chem. 276: 13145-13152.

Boehm, M., Aguilar, R. C., Bonifacino, J. S. 2001. Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs). Embo J. 20: 6265-6276.

Caplan, S., Hartnell, L. M., Aguilar, R. C., Naslavsky, N., Bonifacino, J. S. 2001. Human Vam6p promotes lysosome clustering and fusion in vivo. J Cell Biol. 154: 109-122.

Martina, J. A., Bonangelino, C. J., Aguilar, R. C., Bonifacino, J. S. 2001. Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery. J Cell Biol. 153: 1111-1120.

Puertollano, R., Aguilar, R. C., Gorshkova, I., Crouch, R. J., Bonifacino, J. S. 2001. Sorting of mannose 6-phosphate receptors mediated by the GGAs. Science. 292: 1712-1716.

Aguilar, R. C., Blank, V. C., Retegui, L. A., Roguin, L. P. 2000. Positive cooperative effects between receptors induced by an anti-human growth hormone allosteric monoclonal antibody. Life Sci. 66: 1021-1031.

Dell'Angelica, E. C., Aguilar, R. C., Wolins, N., Hazelwood, S., Gahl, W. A., Bonifacino, J. S. 2000. Molecular characterization of the protein encoded by the Hermansky-Pudlak syndrome type 1 gene. J Biol Chem. 275: 1300-1306.

Dell'Angelica, E. C., Puertollano, R., Mullins, C., Aguilar, R. C., Vargas, J. D., Hartnell, L. M., Bonifacino, J. S. 2000. GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. J Cell Biol. 149: 81-94.

Dell'Angelica, E. C., Shotelersuk, V., Aguilar, R. C., Gahl, W. A., Bonifacino, J. S. 1999. Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the β3A subunit of the AP-3 adaptor. Mol Cell. 3: 11-21.

Gough, N. R., Zweifel, M. E., Martinez-Augustin, O., Aguilar, R. C., Bonifacino, J. S., Fambrough, D. M. 1999. Utilization of the indirect lysosome targeting pathway by lysosome-associated membrane proteins (LAMPs) is influenced largely by the C-terminal residue of their GYXXΦ targeting signals. J Cell Sci. 112 ( Pt 23): 4257-4269.

Ohno, H., Tomemori, T., Nakatsu, F., Okazaki, Y., Aguilar, R. C., Foelsch, H., Mellman, I., Saito, T., Shirasawa, T., Bonifacino, J. S. 1999. μ1B, a novel adaptor medium chain expressed in polarized epithelial cells. FEBS Lett. 449: 215-220.

Aguilar, R. C., Blank, V. C., Retegui, L. A., Roguin, L. P. 1998. Detection of negative allosteric effects between monoclonal antibodies by using an antigenic model-builder computer program. Comput Biol Med. 28: 61-73.

Ohno, H., Aguilar, R. C., Yeh, D., Taura, D., Saito, T., Bonifacino, J. S. 1998. The medium subunits of adaptor complexes recognize distinct but overlapping sets of tyrosine-based sorting signals. J Biol Chem. 273: 25915-25921.

Aguilar, R. C., Ohno, H., Roche, K. W., Bonifacino, J. S. 1997. Functional domain mapping of the clathrin-associated adaptor medium chains μ1 and μ2. J Biol Chem. 272: 27160-27166.

Ohno, H., Aguilar, R. C., Fournier, M-C., Hennecke, S., Cosson, P., Bonifacino, J. S. 1997. Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family. Virology. 238: 305-315.

Roguin, L. P., Aguilar, R. C., Retegui, L. A. 1995. Monoclonal antibodies to human growth hormone modulate its biological properties. Mol Immunol. 32: 399-405.

Aguilar, R. C., Retegui, L. A., Postel-Vinay, M-C., Roguin, L. P. 1994. Allosteric effects of monoclonal antibodies on human growth hormone. Mol Cell Biochem. 136: 35-42.

Aguilar, R. C., Retegui, L. A., Roguin, L. P. 1994. MAPAG: a computer program to construct 2- and 3-dimensional antigenic maps. Int J Biomed Comput. 37: 225-235.

Bartke, A., Turyn, D., Aguilar, C. C., Sotelo, A. I., Steger, R. W., Chen, X. Z., Kopchick, J. J. 1994. Growth hormone (GH) binding and effects of GH analogs in transgenic mice. Proc Soc Exp Biol Med. 206: 190-194.

Aguilar, R. C., Fernandez, H. N., Dellacha, J. M., Calandra, R. S., Bartke, A., Ghosh, P. K., Turyn, D. 1992. Somatotropic and lactotropic receptors in transgenic mice expressing human or bovine growth hormone genes. Transgenic Res. 1: 221-227.

Aguilar, R. C., Fernández, H. N., Dellacha, J. M., Calandra, R. S., Bartke, A., Turyn, D. 1992. Identification of somatogenic binding sites in liver microsomes from normal mice and transgenic mice expressing human growth hormone gene. Life Sci. 50: 615-620.

Book Section

Aguilar, R. C. 2017. Epsin. In: Encylopedia of Signaling Molecules, S. Choi (Ed.), Springer, New York, N. Y.

Madhivanan, K., Hsieh, W.-C., Aguilar, R. C. 2016. Adaptor Proteins: Inter-Organelle Traffic Controllers. In Encyclopedia of Cell Biology, Vol. 2, R.A. Bradshaw, P.D. Stahl (Eds.), pp. 450-458. Academic Press, Waltham.


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