Stephen Konieczny Publications


Sakitani, K., Hayakawa, Y., Deng, H., Ariyama, H., Kinoshita, H., Konishi, M., Suzuki, N., Ihara, S., Niu, Z., Kim, W., Tanaka, T., Liu, H., Chen, X., Tailor, Y., Fox, J.G., Konieczny, S.F., Hirata, Y., Asfaha, S., Sepulveda, A.R., Koike, K., and Wang, T.C. 2017. CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development. Oncotarget  In press.

Lo, H.-Y.G., Jin, R.U., Sibbel, G., Liu, D., Karki, A., Joens, M.S., Madison, B.B., Zhang, B., Blanc, V., Fitzpatrick, J.A.J., Davidson, N.O., Konieczny, S.F., and Mills, J.C. 2017. A single transcription factor is sufficient to induce and maintain secretory cell architecture. Genes Dev. 31:154-171. view article

Li, J., Gu, D., Lee, S.S.-Y., Song, B., Bandyopadhyay, S., Chen, S., Konieczny, S.F., Ratliff, T.L., Liu, X., Xie, J., and Cheng, J.-X. 2016. Abrogating Cholesterol Esterification Suppresses Growth and Metastasis of Pancreatic Cancer. Oncogene 35:6378-6388. view article

Han, B., Qu, C., Park, K., Konieczny, S.F., and Korc, M. 2016. Recapitulation of Complex Transport and Action of Drugs at the Tumor Microenvironment Using Tumor-Micorenvironment-on-Chip. Cancer Lett. 380:319-329. view article

Hess, D.A., Strelau, K.M., Karki, A., Jiang, M., Azevedo-Pouly, A.C., Lee, A.H., Deering, T.G., Hoang, C.Q., MacDonald, R.J., Konieczny, S.F. 2016. MIST1 Links Secretion and Stress as both Target and Regulator of the Unfolded Protein Response. Mol. Cell Biol. 36:2931-2944. view article

Jiang, M., Azevedo-Pouly, A.C., Deering, T.G., Hoang, C.Q., DiRenzo, D., Hess, D.A., Konieczny, S.F., Swift, G.H., MacDonald, R.J. 2016. MIST1 and PTF1 Collaborate in Feed-Forward Regulatory Loops That Maintain the Pancreatic Acinar Phenotype in Adulty Mice. Mol Cell Biol. 36:2945-2955. view article

Liu, X., Pitarresi, J.R., Cuitiño, M.C., Kladney, R.D., Woelke, S.A., Sizemore, G.M., Nayak, S.G., Egriboz, O., Schweickert, P.G., Yu, L., Trela, S., Schilling, D.J., Halloran, S.K., Li, M., Dutta, S., Fernandez, S.A., Rosol, T.J., Lesinski, G.B., Shakya, R., Ludwig, T., Konieczny, S.F., Leone, G., Wu, J., and Ostrowski, M.C. 2016. Genetic Ablation of Smoothened in Pancreatic Fibroblasts Increases Acinar-ductal Metaplasia. Genes Dev. 30:1943-1955. view article

Pitarresi, J.R., Liu, X., Sharma, S.M., Cuitiño, Kladney, R.D., Mace, T.A., Donohue, S., Nayak, S.G., Qu, C., Lee, J., Woelke, S.A., Trela, S., LaPak, K., Yu, L., McElroy, J., Rosol, T.J., Shakya, R., Ludwig, L., Lesinski, G.B., Fernandez, S.A., Konieczny, S.F., Leone, G., Wu, J., and Ostrowski, M.C. 2016. Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia. Neoplasia 18:541-552. view article

Bi, P., Yue, F., Karki, A., Castro, B., Wirbisky, S.E., Wang, C., Durkes, A., Elzey, B.D., Andrisani, O.M., Bidwell, C.A., Freeman, J.L., Konieczny, S.F., and Kuang, S. 2016. Notch Activation Drives Adipocyte Dedifferentiation and Tumorigenic Transformation in Mice. J. Exp. Med. 213:2019-2037. view article

Li, J., Wang, R., Schweickert, P.G., Karki, A., Yang, Y., Kong, Y., Ahmad, N., Konieczny, S.F., and Liu, X. 2016. Plk1 Inhibition Enhances the Efficacy of Gemcitabine in Human Pancreatic Cancer. Cell Cycle 15:711-719. DOI: 10.1080/15384101.2016.1148838. view article

Karki, A., Humphrey, S.E., Steele, R.E., Hess, D.A., Taparowsky, E.A., and Konieczny, S.F. 2015. Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis. PLoS One 10(12):e0145724. DOI:10.1371/journal.pone.0145724. view article

Zhou, Z., Yang, Y., Konieczny, S.F., and Irudayaraj, J.M.K. 2015. Rapid and Unbiased Exraction of Chromatin Associated RNAs from Purified Native Chromatin. J. Chromatogr. A 1426:64-68. view article

Hayakawa, Y., Ariyama, H., Stancikova, J., Sakitani, K., Asfaha, S., Renz, B.W., Dubeykovskaya, Z.A., Shibata, W., Wang, H., Westphalen, C.B., Chen, X., Takemoto, Y., Kim, W., Khurana, S.S., Tailor, Y., Nagar, K., Tomita, H., Hara, A., Sepulveda, A.R., Setlik, W., Gershon, M.D., Saha, S., Ding, L., Shen, Z., Fox, J.G., Friedman, R.A., Konieczny, S.F., Worthley, D.L., Korinek, V., and Wang, T.C. 2015. Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell 28:800-814. view article

Li, J., Karki, A., Hodges, K.B., Ahmad, N., Zoubeidi, A., Strebhard, K., Ratliff, T.L., Konieczny, S.F., and Liu, X. 2015. Cotargeting Polo-Like Kinase 1 and the Wnt/β-Catenin Signaling Pathway in Castration-Resistant Prostate Cancer. Mol. Cell. Biol. 35:4185-4198. view article

Kim, S.W., Lahmy, R., Riha, C., Yang, C., Jakubison, B., van Niekerk, J., Staub, C., Wu, Y., Gates, K., Dong, D.S., Konieczny, S.F., and Itkin-Ansari, P. 2015. The Basic Helix-Loop-Helix Transcription Factor E47 Reprograms Human Pancreatic Cancer Cells to a Quiescent Acinar State with Reduced Tumorigenic Potential. Pancreas 44:718-727. view article

Aure, M.H., Konieczny, S.F., and Ovitt, C.E. 2015. Salivary Gland Homeostasis Is Maintained through Acinar Cell Self-Duplication. Dev. Cell 33:231-237. view article

Li, Z., Li, J., Bi, P., Lu, Y., Burcham, G., Elzey, B.D., Ratliff, T., Konieczny, S.F., Ahmad, N., Kuang, S., and Liu, X. 2014. Plk1 Phosphorylation of PTEN Causes a Tumor-Promoting Metabolic State. Mol. Cell Biol. 34:3642-3661. view article

Lee, H., Kim, Y., Schweickert, P.G., Koniezny, S.F., and Won, Y.-Y. 2014. A photo-degradable gene delivery sytem for enhanced nuclear gene transcription.  Biomaterials 35:1040-1049. view article

Shi, G., DiRenzo, D., Qu, C., Barney, D., Miley, D., and Konieczny, S.F. 2013. Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia. Oncogene 32:1950-1958. view article

Song, B., Liu, X.S., Rice, S., Elzey, B.D., Konieczny, S.F., Ratliff, T., Hazbun, T., Chiorean, E.G. and Liu, X.  2013.  Plk1 Phosphorylation of Orc2 and Hbo1 Contributes to Gemcitabine Resistance in Pancreatic Cancer.  Mol. Can. Therapeutics  12:58-68. view article

DiRenzo, D., Hess, D.A., Damsz, B., Hallett, J.E., Marshall, C.G., Liu, Y., Deering, T., MacDonald, R.J., and Konieczny, S.F. 2012. Induced Mist1 Expression Promotes Remodeling of Mouse Pancreatic Acinar Cells. Gastroenterology 143:469-80. view article

Godby, R.C., van den Berg, Y.W., Srinivasan, R., Sturm, R., Hui, D.Y., Konieczny, S.F., Aronow, B.J., Ozhegov, E., Ruf, W., Versteeg, H.H., and Bogdanov, V.Y. 2012. Nonproteolytic Properties of Murine Alternatively Spliced Tissue Factor: Implications for Integrin-Mediated Signaling in Murine Models. Molecular Medicine. 18:771-779. view article

Prévot, P-P., Simion, A., Grimont, A., Colletti, M., Khalaileh, A., Van den Steen, G., Sempoux, C., Xu, X., Roelants, V., Hald, J., Bertrand, L., Heimberg, H., Konieczny, S.F., Dor, Y., Lemaigre, F.P., Jacquemin, P. 2012. Role of the ductal transcrioption factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut 61:1723-1732. view article

Hess, D.A., Humphrey, S.E., Ishibashi, J., Damsz, B., Lee, A.-H., Glimcher, L.H. and Konieczny, S.F. 2011. Extensive Pancreas Regeneration Following Acinar-Specific Disruption of Xbp1 in Mice. Gastroenterology 141:1463-1472. view article

Liu, X.S., Song, B., Elzey, B., Ratliff, T.L., Konieczny, S.F., Cheng, L., Ahmad, N. and Liu, X. 2011. Polo-like Kinase 1 Facilitates Loss of Pten Tumor Suppressor-induced Prostate Cancer Formation. J. Biol. Chem. 286:35795-35800. view article

Gary, D.J., Lee, H., Sharma, R., Lee, J.-S., Kim, Y., Cui, Z.Y., Jia, D., Bowman, V.D., Chipman, P.R., Wan, L., Zou, Y., Mao, G., Park, K., Herbert, B.-S., Konieczny, S.F., Won, Y.-Y. 2011. Influence of Nano-Carrier Architecture on in Vitro siRNA Delivery Performance and in Vivo Biodistribution: Polyplexes vs. Miscelleplexes. ACA Nano 5:3493-3505. view article

Coon, B.G., DiRenzo, D.M., Konieczny, S.F., Aguilar, R.C. 2011. Epsins novel role in cancer cell invasion. Commun Integr Biol. 4: 95-97. view article

Nam, K.T., Lee, H.-J., Sousa, J.F., Weis, V.G., O'Neal, R.L., Finke, P.E., Romero-Gallo, J., Shi, G., Mills, J.C., Peek Jr., R.M., Konieczny, S.F., and Goldenring, J.R. 2010. Mature Chief Cells are Cryptic Progenitors for Metaplasia in the Stomach. Gastroenterology 139:2028-2037. view article

Huh, W.J., Esen E., Bredemeyer, A.J., Geahlen, J., Lee, A.-H., Shi, G., Konieczny, S.F., Glimcher, L.H. and Mills, J.C. 2010. XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum. Gastroenterology 139:2038-2049. view article

Garside, V.C., Kowalik, A., Johnson, C., DiRenzo, D., Konieczny, S.F. and Pin, C.L. 2010. MIST1 regulates the pancreatic acinar cell expression of Atp2c2, the gene encoding secretory pathway calcium ATPase2. Exp. Cell Res. 316:2859-2870. view article

Won, Y.-Y., Sharma, R., Konieczny, S.F. 2009. Missing pieces in understanding the intracelluar trafficking of polycation/DNA complexes. J. Controlled Release 139: 88-93. view article

Shi, G., Zhu, L., Sun, Y., Bettencort, R., Damsz, B., Hruban, R. H., Konieczny, S. F. 2009. Loss of the acinar-restricted transcription factor Mist1 accelerates kras-induced pancreatic intraepithelial neoplasia.. Gastorenterology. 136: 1368-1378. view article

Rovira, M., Delaspre, F., Massumi, M., Serra, S. A., Valverde, M. A., Lloreta, J., Dufresne, M., Payre, B., Konieczny, S. F., Savatier, P., Real, F. X., Skoudy, A. 2008. Murine embryonic stem cell-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation. Gastroenterolgy. 135: 1301-1310.

Jia, D., Sun, Y., Konieczny, S. F. 2008. Mist1 regulates pancreatic acinar cell proliferation through p21CIP1/WAF1. Gastroenterology. 135: 1687-1697.

Habbe, N., Shi, G., Meguid, R. A., Fendrich, V., Esni, F., Chen, H., Feldmann, G., Stoffers, D. A., Konieczny, S. F., Leach, S. D., Maitra, A. 2008. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci. 105: 18913-18918.

Sharma, R., Lee, J. -S., Bettencourt, R. C., Xiao, C., Konieczny, S. F., Won, Y. -Y. 2008. Effects of the incorporation of a hydrophobic middle block into a PEG-polycation diblock copolymer on the physicochemcial and cell interaction properties of the polymer-DNA complexes. Biomacromolecules. 9: 3294-3307.

Nozaki, K., Ogawa, M., Williams, J. A., Lafleur, B. J., Ng, V., Drapkin, R. I., Mills, J. C., Konieczny, S. F., Nomura, S., Goldenring, J. R. 2008. A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology. 134: 511-522.

Konieczny, S. F., Leach, S. D. 2007. Metaplastic metamorphoses in the mammalian pancreas. Gastroenterology. 133: 2056-2059.

Ramsey, V. G., Doherty, J. M., Chen, C. C., Stappenbeck, T. S., Konieczny, S. F., Mills, J. C. 2007. The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development. 134: 211-222.

Tran, T., Jia, D., Sun, Y., Konieczny, S. F. 2007. The bHLH domain of Mist1 is sufficient to activate gene transcription. Gene Expr. 13: 241-253.

Zhu, L., Shi, G., Schmidt, C. M., Hruban, R. H., Konieczny, S. F. 2007. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol. 171: 263-273. view article

Tuveson, D. A., Zhu, L., Gopinathan, A., Willis, N. A., Kachatrian, L., Grochow, R., Pin, C. L., Mitin, N. Y., Taparowsky, E. J., Gimotty, P. A., Hruban, R. H., Jacks, T., Konieczny, S. F. 2006. Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Cancer Res. 66: 242-247.

Zhao, Y., Johansson, C., Tran, T., Bettencourt, R., Itahana, Y., Desprez, P. -Y., Konieczny, S. F. 2006. Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required for maintenance of the differentiated state. Mol Endocrinol.

Konieczny, S. F. 2006. Mist1. AfCS-Nature Molecule Pages. doi:10.1038/mp.a003676.01.

Luo, X., Shin, D. M., Wang, X., Konieczny, S. F., Muallem, S. 2005. Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice. J Biol Chem. 280: 12668-12675.

Mitin, N., Konieczny, S. F., Taparowsky, E. J. 2005. RAS and the RAIN/RasIP1 Effector. Methods Enzymol. 407: 322-335.

Mitin, N. Y., Ramocki, M. B., Zullo, A. J., Der, C. J., Konieczny, S. F., Taparowsky, E. J. 2004. Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. J Biol Chem. 279: 22353-22361.

Zhu, L., Tran, T., Rukstalis, J. M., Sun, P., Damsz, B., Konieczny, S. F. 2004. Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia. Mol Cell Biol. 24: 2673-2681.

Rukstalis, J. M., Kowalik, A., Zhu, L., Lidington, D., Pin, C. L., Konieczny, S. F. 2003. Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1. J Cell Sci. 116: 3315-3325.

Flick, M. J., Konieczny, S. F. 2002. Identification of putative mammalian D-lactate dehydrogenase enzymes. Biochem Biophys Res Commun. 295: 910-916.

Pin, C. L., Konieczny, S. F. 2002. A fast fiber enhancer exists in the muscle regulatory factor 4 gene promoter. Biochem Biophys Res Commun. 299: 7-13.

Wyzykowski, J. C., Winata, T. I., Mitin, N., Taparowsky, E. J., Konieczny, S. F. 2002. Identification of novel MyoD gene targets in proliferating myogenic stem cells. Mol Cell Biol. 22: 6199-6208.

Mitin, N., Kudla, A. J., Konieczny, S. F., Taparowsky, E. J. 2001. Differential effects of Ras signaling through NFκB on skeletal myogenesis. Oncogene. 20: 1276-1286.

Pin, C. L., Rukstalis, J. M., Johnson, C., Konieczny, S. F. 2001. The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J Cell Biol. 155: 519-530.

Mitin, N., Ramocki, M. B., Konieczny, S. F., and Taparowsky, E. J. 2001. Ras regulation of skeletal muscle differentiation and gene expression. Methods Enzymol. 333: 232-247.

Flick, M. J., Konieczny, S. F. 2000. The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of βI-spectrin. J Cell Sci. 113 ( Pt 9): 1553-1564.

Peña, T. L., Chen, S. H., Konieczny, S. F., Rane, S. G., . 2000. Ras/MEK/ERK Up-regulation of the fibroblast KCa channel FIK is a common mechanism for basic fibroblast growth factor and transforming growth factor-β suppression of myogenesis. J Biol Chem. 275: 13677-13682.

Pin, C. L., Bonvissuto, A. C., Konieczny, S. F. 2000. Mist1 expression is a common link among serous exocrine cells exhibiting regulated exocytosis. Anat Rec. 259: 157-167.

Pin, C. L., Lemercier, C., Konieczny, S. F. 1999. Cloning of the murine Mist1 gene and assignment to mouse chromosome band 5G2-5G3. Cytogenet Cell Genet. 86: 219-222.

Lemercier, C., To, R. Q., Carrasco, R. A., Konieczny, S. F. 1998. The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of MyoD. EMBO J. 17: 1412-1422.

Ramocki, M. B., White, M. A., Konieczny, S. F., Taparowsky, E. J. 1998. A role for RalGDS and a novel Ras effector in the Ras-mediated inhibition of skeletal myogenesis. J Biol Chem. 273: 17696-17701.

Kong, Y., Flick, M. J., Kudla, A. J., Konieczny, S. F. 1997. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol Cell Biol. 17: 4750-4760.

Lemercier, C., To, R. Q., Swanson, B. J., Lyons, G. E., Konieczny, S. F. 1997. Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern. Dev Biol. 182: 101-113.

Pin, C. L., Ludolph, D. C., Cooper, S. T., Klocke, B. J., Merlie, J. P., Konieczny, S. F. 1997. Distal regulatory elements control MRF4 gene expression in early and late myogenic cell populations. Dev Dyn. 208: 299-312.

Ramocki, M. B., Johnson, S. E., White, M. A., Ashendel, C. L., Konieczny, S. F., Taparowsky, E. J. 1997. Signaling through mitogen-activated protein kinase and Rac/Rho does not duplicate the effects of activated Ras on skeletal myogenesis. Mol Cell Biol. 17: 3547-3555.

Johnson, S. E., Wang, X., Hardy, S., Taparowsky, E. J., Konieczny, S. F. 1996. Casein kinase II increases the transcriptional activities of MRF4 and MyoD independently of their direct phosphorylation. Mol Cell Biol. 16: 1604-1613.

Mak, K. -L., Longcor, L. C., Johnson, S. E., Lemercier, C., To, R. Q., Konieczny, S. F. 1996. Examination of mammalian basic helix-loop-helix transcription factors using a yeast one-hybrid system. DNA Cell Biol. 15: 1-8.

Kong, Y., Johnson, S. E., Taparowsky, E. J., Konieczny, S. F. 1995. Ras p21Val inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix-loop-helix factors. Mol Cell Biol. 15: 5205-5213.

Ludolph, D. C., Konieczny, S. F. 1995. Transcription factor families: muscling in on the myogenic program. FASEB J. 9: 1595-1604.

Naidu, P. S., Ludolph, D. C., To, R. Q., Hinterberger, T. J., Konieczny, S. F. 1995. Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis. Mol Cell Biol. 15: 2707-2718.

Hardy, S., Kong, Y., Konieczny, S. F. 1993. Fibroblast growth factor inhibits MRF4 activity independently of the phosphorylation status of a conserved threonine residue within the DNA-binding domain. Mol Cell Biol. 13: 5943-5956.

Smith, T. H., Block, N. E., Rhodes, S. J., Konieczny, S. F., Miller, J. B. 1993. A unique pattern of expression of the four muscle regulatory factor proteins distinguishes somitic from embryonic, fetal and newborn mouse myogenic cells. Development. 117: 1125-1133.

Voytik, S. L., Przyborski, M., Badylak, S. F., Konieczny, S. F. 1993. Differential expression of muscle regulatory factor genes in normal and denervated adult rat hindlimb muscles. Dev Dyn. 198: 214-224.

Epstein, H. F., Fischman, D. A., Bader, D., Changeux, J. P., Buckhold, K., Ordahl, C. P., Hoffman, E., Kedes, L. H., Konieczny, S. F., Leinwand, L. A. 1992. Myoblast therapy. Science. 257: 738.

Hinterberger, T. J., Mays, J. L., Konieczny, S. F. 1992. Structure and myofiber-specific expression of the rat muscle regulatory gene MRF4. Gene. 117: 201-207.

Lin, H., Konieczny, S. F. 1992. Identification of MRF4, myogenin, and E12 oligomer complexes by chemical cross-linking and two-dimensional gel electrophoresis. J Biol Chem. 267: 4773-4780.

Mak, K. L., To, R. Q., Kong, Y., Konieczny, S. F. 1992. The MRF4 activation domain is required to induce muscle-specific gene expression. Mol Cell Biol. 12: 4334-4346.

Vaidya, T. B., Rhodes, S. J., Moore, J. L., Sherman, D. A., Konieczny, S. F., Taparowsky, E. J. 1992. Isolation and structural analysis of the rat MyoD gene. Gene. 116: 223-230.

Yutzey, K. E., Konieczny, S. F. 1992. Different E-box regulatory sequences are functionally distinct when placed within the context of the troponin I enhancer. Nucleic Acids Res. 20: 5105-5113.

Hinterberger, T. J., Sassoon, D. A., Rhodes, S. J., Konieczny, S. F. 1991. Expression of the muscle regulatory factor MRF4 during somite and skeletal myofiber development. Dev Biol. 147: 144-156.

Lin, H., Yutzey, K. E., Konieczny, S. F. 1991. Muscle-specific expression of the troponin I gene requires interactions between helix-loop-helix muscle regulatory factors and ubiquitous transcription factors. Mol Cell Biol. 11: 267-280.

Enkemann, S. A., Konieczny, S. F., Taparowsky, E. J. 1990. Adenovirus 5 E1A represses muscle-specific enhancers and inhibits expression of the myogenic regulatory factor genes, MyoD1 and myogenin. Cell Growth Differ. 1: 375-382.

Yutzey, K. E., Rhodes, S. J., Konieczny, S. F. 1990. Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4. Mol Cell Biol. 10: 3934-3944.

Konieczny, S. F., Drobes, B. L., Menke, S. L., Taparowsky, E. J. 1989. Inhibition of myogenic differentiation by the H-ras oncogene is associated with the down regulation of the MyoD1 gene. Oncogene. 4: 473-481.

Rhodes, S. J., Konieczny, S. F. 1989. Identification of MRF4: a new member of the muscle regulatory factor gene family. Genes Dev. 3: 2050-2061.

Vaidya, T. B., Rhodes, S. J., Taparowsky, E. J., Konieczny, S. F. 1989. Fibroblast growth factor and transforming growth factor-β repress expression of the myogenic regulatory gene MyoD1. Mol Cell Biol. 9: 3576-3579.

Yutzey, K. E., Kline, R. L., Konieczny, S. F. 1989. An internal regulatory element controls troponin I gene expression. Mol Cell Biol. 9: 1397-1405.

Bucher, E. A., Maisonpierre, P. C., Konieczny, S. F., Emerson, C. P., Jr. 1988. Expression of the troponin complex genes: transcriptional coactivation during myoblast differentiation and independent control in heart and skeletal muscles. Mol Cell Biol. 8: 4134-4142.

Pinney, D. F., Pearson-White, S. H., Konieczny, S. F., Latham, K. E., Emerson, C. P., Jr. 1988. Myogenic lineage determination and differentiation: evidence for a regulatory gene pathway. Cell. 53: 781-793.

Konieczny, S. F., Emerson, C. P., Jr. 1987. Complex regulation of the muscle-specific contractile protein (troponin I) gene. Mol Cell Biol. 7: 3065-3075.

Konieczny, S. F., Emerson, C. P., Jr. 1985. Differentiation, not determination, regulates muscle gene activation: transfection of troponin I genes into multipotential and muscle lineages of 10T1/2 cells. Mol Cell Biol. 5: 2423-2432.

Konieczny, S. F., Emerson, C. P., Jr. 1984. 5-Azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: evidence for regulatory genes controlling determination. Cell. 38: 791-800.

Konieczny, S. F., Coleman, J. R. 1983. Analysis of myogenesis by somatic cell hybridization: III. Myogenic competence of hybrids derived from rat L6 myoblasts and mouse primary fibroblasts and myoblasts. Somatic Cell Genet. 9: 25-42.

Konieczny, S. F., Lawrence, J. B., Coleman, J. R. 1983. Analysis of muscle protein expression in polyethylene glycol-induced chicken: rat myoblast heterokaryons. J Cell Biol. 97: 1348-1355.

Konieczny, S. F., Coleman, J. R. 1982. Analysis of the expression of chicken and rat gene products in myoblast x myoblast cell hybrids. Exp Cell Res. 142: 247-260.

Konieczny, S. F., McKay, J., Coleman, J. R. 1982. Isolation and characterization of terminally differentiated chicken and rat skeletal muscle myoblasts. Dev Biol. 91: 11-26.

Lawrence, J. B., Konieczny, S. F., Shaffer, M., Coleman, A. W., Coleman, J. R. 1982. Analysis of myogenesis by somatic cell hybridization: I. Myogenic competence of homotypic hybrids derived from rat L6 myoblasts. Exp Cell Res. 142: 261-272.

Dexter, D. L., Konieczny, S. F., Lawrence, J. B., Shaffer, M., Mitchell, P., Coleman, J. R. 1981. Induction by butyrate of differentiated properties in cloned murine rhabdomyosarcoma cells. Differentiation. 18: 115-122.

Book Section

Mitin, N., Ramocki, M.B., Konieczny, S.F., and Taparowsky, E.J. 2001. Ras regulation of skeletal muscle differentiation and gene expression.  In Methods of Enzymology, Regulators and Effectors of Small GTPases.  Balch, W.E., Der, C.J., and Hall, A. (eds), Academic Press. Methods Enzymol. 333: 232-247.


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