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Christopher Staiger Publications


Li, J., Staiger, C. J. 2018. Understanding cytoskeletal dynamics during the plant immune response. Annu Rev Phytopathol. 56:513-533. view article

Zhou, W., Cao, L., Jeffries, L., Zhu, X., Staiger, C. J., Deng, Q. 2018. Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish. Dis Model Mech. 11: pii: dmm033027.

Kijima, S. T., Staiger, C. J., Katoh, K., Nagasaki, A., Ito, K., Uyeda, T. Q. P. 2018. Arabidopsis vegetative actin isoforms, AtACT2 and AtACT7, generate distinct filament arrays in living plant cells. Sci Rep. 8:4381.

Szymanski, D., Staiger, C. J. 2018. The actin cytoskeleton: Functional arrays for cytoplasmic organization and cell shape control. Plant Physiol. 176:106-118.

Li, J., Cao, L., Staiger, C. J. 2017. Capping protein modulates actin remodeling in response to reactive oxygen species during plant innate immunity. Plant Physiol. 173:1125-1136.

Liu, Y., Zhu, W., Tan, Y., Nakayasu, E. S., Staiger, C. J., Luo, Z.-Q. 2017. A Legionella effector disrupts host cytoskeletal structure by cleaving actin. PLoS Pathog. 13:e1006186.

Shimonon, M., Lu, Y.-J., Porter, K., Kvitko, B. H., Henty-Ridilla, J., Creason, A., He, S. Y., Chang, J. H., Staiger, C. J., Day, B. 2016. The Pseudomonas syringae type III effector HopG1 induces actin remodeling to promote symptom development and susceptibility during infection. Plant Physiol. 171:2239-2255.

Zhang, S., Liu, C., Wang, J., Ren, Z., Staiger, C. J. and Ren, H. 2016. A processive Arabidopsis formin modulates actin filament dynamics in association with profilin. Mol Plant 9: 900-910.

Staiger, C. J. 2016. MAPping the function of phytopathogen effectors. Cell Host Microbe 19: 7-9.

Cao, L., Henty-Ridilla, J. L., Blanchoin, L. and Staiger, C. J. 2016. Profilin-dependent nucleation and assembly of actin filaments controls cell elongation in Arabidopsis. Plant Physiol. 170: 220-233.

Li, J., Henty-Ridilla, J. L., Staiger, B. H., Day, B. and Staiger, C. J. 2015. Capping protein integrates multiple MAMP signalling pathways to modulate actin dynamics during plant innate immunity. Nat Commun. 6:7206.

Li, J., Blanchoin, L. and Staiger, C. J. 2015. Signaling to actin stochastic dynamics. Annu Rev Plant Biol. 66: 415-440.

Jimenez-Lopez, J. C., Wang, X., Kotchoni, S. O., Huang, S., Szymanski, D. B. and Staiger, C. J. 2014. Heterodimeric capping protein from Arabidopsis is a membrane-associated, actin-binding protein. Plant Physiol. 166: 1312-1328.

Cai, C., Henty-Ridilla, J. L., Szymanski, D. B. and Staiger, C. J. 2014. Arabidopsis myosin XI: a motor rules the tracks. Plant Physiol. 166: 1359-1370.

Thomas, C. and Staiger, C. J. 2014. A dynamic interplay between membranes and the cytoskeleton critical for cell development and signaling. Front Plant Sci. 5: 335.

Li, J., Staiger, B. H., Henty-Ridilla, J. L., Abu-Abied, M., Sadot, E., Blanchoin, L., and Staiger, C. J. 2014. The availability of filament ends modulates actin stochastic dynamics in live plant cells. Mol Biol Cell. 25: 1263-1275.

Henty-Ridilla, J. L., Li, J., Day, B., and Staiger, C. J. 2014. ACTIN DEPOLYMERIZING FACTOR4 regulates actin dynamics during innate immune signaling in Arabidopsis. Plant Cell 26: 340-352.

Mukherjee, D., Sen, A., Boettner, D. R., Fairn, G. D., Schlam, D., Bonilla Valentin, F. J., Michael McCaffery, J., Hazbun, T., Staiger, C. J. Grinstein, S., Lemmon, S. K., and Aguilar, R. C. 2013. Bem3, a Cdc42 GTPase-activating protein, traffics to an intracellular compartment and recruits the secretory Rab GTPase Sec 4 to endomembranes.  J Cell Science. 126(Pt 20): 4560-4571.

Hou, X., Li Z., Huang, W., Li, J., Staiger, C., Kuang, S., Ratliff, T., and Liu, X. 2013. Plk1-Dependent Microtubule Dynamics Promotes Androgen Receptor Signaling in Prostate Cancer. Prostate. 73: 1352-1363.

Henty-Ridilla, J. L., Shimono, M., Li, J., Chang, J. H., Day, B., and Staiger, C. J. 2013. The Plant Actin Cytoskeleton Responds to Signals from Microbe-Associated Molecular Patterns. PLoS Pathog. 9(4): e1003290

Pleskot, R., Premysl P., Zárský, V., Staiger, C. J., and Potocký, M. 2012. Protein by Interactions with Phosphatidic Acid and Phosphatidylinosity (4,5)-Bisphosphate. PLoS Comput Biol. 8(11): e1002765. doi: 10.1372/journal.pcbi.1002765

Li, J., Henty-Ridilla, J. L., Huang, S., Wang, S., Blanchoin, L., and Staiger, C. J. 2012. Capping Protein Modulates the Dynamic Behavior of Actin Filaments in Response to Phosphatidic Acid in Arabidopsis. Plant Cell. 24: 3742-3754.

Pleskot, R., Pejchar, P., Staiger, C. J., and Potocký, M. 2014. When fat is not bad: the regulation of actin dynamics by phospholipid signaling molecules. Front Plant Sci. 5(5): 1-6.  doi: 10.3389/fpls.2014.00005

Henty-Ridilla, J. L., Li, J., Blanchoin, L., and Staiger, C. J.  2013.  Actin dynamics in the cortical array of plant cells.  Curr Opin Plant Biol 16(6): 678-687.

Pleskot, R., Li, J., Zárský, V., Potocký, M. and Staiger, C. J.  2013.  Regulation of cystoskeletal dynamics by phospholipase D and phosphatidic acid.  Trends Plant Sci. 18(9): 496-504.

Li, J., Pleskot, R., Henty-Ridilla, J. L., Blanchoin, L., Potocký, M., and Staiger, C. J.  2012.  Arabidopsis capping protein senses cellular phosphatidic acid levels and transduces these into changes in actin cytoskeleton dynamics.  Plant Signal Behav.  7(12): 1727-1730.

Whippo, C. W., Khurana, P., Davis, P. A., DeBlasio, S. L., DeSloover, D., Staiger, C. J., Hangarter, R. P. 2011. THRUMIN1 is a light-regulated actin-bundling protein involved in chloroplast motility. Curr Biol. 21: 59-64.

Reymann, A-C., Suarez, C., Guérin, C., Martiel, J-L., Staiger, C. J., Blanchoin, L., Boujemaa-Paterski, R. 2011. Turnover of branched actin filament networks by stochastic fragmentation with ADF/cofilin. Mol Biol Cell. 22: 2541-2550.

Day, B., Henty, J. L., Porter, K. J., Staiger, C. J. 2011. The pathogen-actin connection: a platform for defense signaling in plants. Annu Rev Phytopathol. 49: 483-506.

Henty, J. L., Bledsoe, S. W., Khurana, P., Meagher, R. B., Day, B., Blanchoin, L., Staiger, C. J. 2011. Arabidopsis actin depolymerizing factor4 modulates the stochastic dynamic behavior of actin filaments in the cortical array of epidermal cells. Plant Cell. 23: 3711-3726.

Blanchoin, L., Staiger, C. J. 2010. Plant formins: Diverse isoforms and unique molecular mechanism. Biochim Biophys Acta Mol Cell Res. 1803: 201-206.

Staiger, C. J., Poulter, N. S., Henty, J. L., Franklin-Tong, V. E., Blanchoin, L. 2010. Regulation of actin dynamics by actin-binding proteins in pollen. J Exp Bot. 61: 1969-1986.

Poulter, N. S., Staiger, C. J., Rappoport, J. Z., Franklin-Tong, V. 2010. Actin-binding proteins implicated in the formation of the punctate actin foci stimulated by the self-incompatibility response in Papaver. Plant Physiol. 152: 1274-1283.

Farquharson, K. L., Staiger, C. J. 2010. Dissecting the functions of class XI myosins in moss and Arabidopsis. Plant Cell. 22: 1649.

Blanchoin, L., Boujemaa-Paterski, R., Henty, J. L., Khurana, P., Staiger, C. J. 2010. Actin dynamics in plant cells: a team effort from multiple proteins orchestrates this very fast-paced game. Curr Opin Plant Biol. 13: 714-723.

Zhang, H., Qu, X., Bao, C., Khurana, P., Wang, Q., Xie, Y., Zheng, Y., Chen, N., Blanchoin, L., Staiger, C. J., Huang, S. 2010. Arabidopsis VILLIN5, an actin filament bundling and severing protein, is necessary for normal pollen tube growth. Plant Cell. 22: 2749-2767.

Khurana, P., Henty, J. L., Huang, S., Staiger, A. M., Blanchoin, L., Staiger, C. J. 2010. Arabidopsis VILLIN1 and VILLIN3 have overlapping and distinct activities in actin bundle formation and turnover. Plant Cell. 22: 2727-2748.

Staiger, C. J., Sheahan, M. B., Khurana, P., Wang, X., McCurdy, D. W., Blanchoin, L. 2009. Actin filament dynamics are dominated by rapid growth and severing activity in the Arabidopsis cortical array. J Cell Biol. 184: 269-280.

Tian, M., Chaudhry, F., Ruzicka, D. R., Meagher, R. B., Staiger, C. J., Day, B. 2009. Arabidopsis actin-depolymerizing factor AtADF4 mediates defense signal transduction triggered by the Pseudomonas syringae effector AvrPphB1. Plant Physiol. 150: 815-824.

Choi, Y., Lee, Y., Jeon, B. W., Staiger, C. J., Lee, Y. 2008. Phosphatidylinositol 3- and 4-phosphate modulate actin filament reorganization in guard cells of day flower. Plant Cell Environ. 31: 366-377.

Zhang, C., Mallery, E. L., Schlueter, J., Huang, S., Fan, Y., Brankle, S., Staiger, C. J., Szymanski, D. B. 2008. Arabidopsis SCARs function interchangeably to meet actin-related protein 2/3 activation thresholds during morphogenesis. Plant Cell. 20: 995-1011.

Lee, Y., Kim, E-S., Choi, Y., Hwang, I., Staiger, C. J., Chung, Y-Y., Lee, Y. 2008. The Arabidopsis phosphatidylinositol 3-kinase is important for pollen development. Plant Physiol. 147: 1886-1897.

Chang, J., Myeni, S. K., Lin, T. L., Wu, C. C., Staiger, C. J., Zhou, D. 2007. SipC multimerization promotes actin nucleation and contributes to Salmonella-induced inflammation. Mol Microbiol. 66: 1548-1556.

Chaudhry, F., Guérin, C., von Witsch, M., Blanchoin, L., Staiger, C. J. 2007. Identification of Arabidopsis cyclase-associated protein 1 as the first nucleotide exchange factor for plant actin. Mol Biol Cell. 18: 3002-3014.

Michelot, A., Berro, J., Guérin, C., Boujemaa-Paterski, R., Staiger, C. J., Martiel, J-L., Blanchoin, L. 2007. Actin-filament stochastic dynamics mediated by ADF/cofilin. Curr Biol. 17: 825-833.

Abu-Abied, M., Golomb, L., Belausov, E., Huang, S., Geiger, B., Kam, Z., Staiger, C. J., Sadot, E. 2006. Identification of plant cytoskeleton-interacting proteins by screening for actin stress fiber association in mammalian fibroblasts. Plant J. 48: 367-379.

Huang, S., Gao, L., Blanchoin, L., Staiger, C. J. 2006. Heterodimeric capping protein from Arabidopsis is regulated by phosphatidic acid. Mol Biol Cell. 17: 1946-1958.

Michelot, A., Derivery, E., Paterski-Boujemaa, R., Guérin, C., Huang, S., Parcy, F., Staiger, C. J., Blanchoin, L. 2006. A novel mechanism for the formation of actin-filament bundles by a nonprocessive formin. Curr Biol. 16: 1924-1930.

Staiger, C. J., Blanchoin, L. 2006. Actin dynamics: old friends with new stories. Curr Opin Plant Biol. 9: 554-562.

Thomas, S. G., Huang, S., Li, S., Staiger, C. J., Franklin-Tong, V. E. 2006. Actin depolymerization is sufficient to induce programmed cell death in self-incompatible pollen. J Cell Biol. 174: 221-229.

Basu, D., Le, J., El-Essal S. E-D., Huang, S., Zhang, C., Mallery, E. L., Koliantz, G., Staiger, C. J., Szymanski, D. B. 2005. DISTORTED3/SCAR2 is a putative Arabidopsis WAVE complex subunit that activates the Arp2/3 complex and is required for epidermal morphogenesis. Plant Cell. 17: 502-524.

Huang, S., Robinson, R. C., Gao, L. Y., Matsumoto, T., Brunet, A., Blanchoin, L., Staiger, C. J. 2005. Arabidopsis VILLIN1 generates actin filament cables that are resistant to depolymerization. Plant Cell. 17: 486-501.

Michelot, A., Guérin, C., Huang, S., Ingouff, M., Richard, S., Rodiuc, N., Staiger, C. J., Blanchoin, L. 2005. The formin homology 1 domain modulates the actin nucleation and bundling activity of Arabidopsis FORMIN1. Plant Cell. 17: 2296-2313.

Yokota, E., Tominaga, M., Mabuchi, I., Tsuji, Y., Staiger, C. J., Oiwa, K., Shimmen, T. 2005. Plant villin, lily P-135-ABP, possesses G-actin binding activity and accelerates the polymerization and depolymerization of actin in a Ca2+-sensitive manner. Plant Cell Physiol. 46: 1690-1703.

Yong, W., Link, B., O'Malley, R., Tewari, J., Hunter, C. T., Lu, C-A., Li, X., Bleecker, A. B., Koch, K. E., McCann, M. C., McCarty, D. R., Patterson, S. E., Reiter, W-D., Staiger, C., Thomas, S. R., Vermerris, W., Carpita, N. C. 2005. Genomics of plant cell wall biogenesis. Planta. 221: 747-751. view article

Fan, X., Hou, J., Chen, X., Chaudhry, F., Staiger, C. J., Ren, H. 2004. Identification and characterization of a Ca2+-dependent actin filament-severing protein from lily pollen. Plant Physiol. 136: 3979-3989.

Huang, S., Blanchoin, L., Chaudhry, F., Franklin-Tong, V. E., Staiger, C. J. 2004. A gelsolin-like protein from Papaver rhoeas pollen (PrABP80) stimulates calcium-regulated severing and depolymerization of actin filaments. J Biol Chem. 279: 23364-23375.

Klein, M. G., Shi, W., Ramagopal, U., Tseng, Y., Wirtz, D., Kovar, D. R., Staiger, C. J., Almo, S. C. 2004. Structure of the actin crosslinking core of fimbrin. Structure. 12: 999-1013.

Park, G., Bruno, K. S., Staiger, C. J., Talbot, N. J., Xu, J-R. 2004. Independent genetic mechanisms mediate turgor generation and penetration peg formation during plant infection in the rice blast fungus. Mol Microbiol. 53: 1695-1707.

Preuss, M. L., Kovar, D. R., Lee, Y-R., Staiger, C. J., Delmer, D. P., Liu, B. 2004. A plant-specific kinesin binds to actin microfilaments and interacts with cortical microtubules in cotton fibers. Plant Physiol. 136: 3945-3955.

Sheahan, M. B., Staiger, C. J., Rose, R. J., McCurdy, D. W. 2004. A green fluorescent protein fusion to actin-binding domain 2 of Arabidopsis fimbrin highlights new features of a dynamic actin cytoskeleton in live plant cells. Plant Physiol. 136: 3968-3978.

Drøbak, B. K., Franklin-Tong, V. E., Staiger, C. J. 2004. Tansley Review: The role of the actin cytoskeleton in plant cell signaling. New Phytol. 163: 13-30.

Huang, S., Blanchoin, L., Kovar, D. R., Staiger, C. J. 2003. Arabidopsis capping protein (AtCP) is a heterodimer that regulates assembly at the barbed ends of actin filaments. J Biol Chem. 278: 44832-44842.

McGough, A. M., Staiger, C. J., Min, J-K., Simonetti, K. D. 2003. The gelsolin family of actin regulatory proteins: modular structures, versatile functions. FEBS Lett. 552: 75-81.

Staiger, C. J., Franklin-Tong, V. E. 2003. The actin cytoskeleton is a target of the self-incompatibility response in Papaver rhoeas. J Exp Bot. 54: 103-113.

Snowman, B. N., Kovar, D. R., Shevchenko, G., Franklin-Tong, V. E., Staiger, C. J. 2002. Signal-mediated depolymerization of actin in pollen during the self-incompatibility response. Plant Cell. 14: 2613-2626.

Bruno, K. S., Morrell, J. L., Hamer, J. E., Staiger, C. J. 2001. SEPH, a Cdc7p orthologue from Aspergillus nidulans, functions upstream of actin ring formation during cytokinesis. Mol Microbiol. 42: 3-12.

Kovar, D. R., Drøbak, B. K., Collings, D. A., Staiger, C. J. 2001. The characterization of ligand-specific maize (Zea mays) profilin mutants. Biochem J. 358: 49-57.

Kovar, D. R., Gibbon, B. C., McCurdy, D. W., Staiger, C. J. 2001. Fluorescently-labeled fimbrin decorates a dynamic actin filament network in live plant cells. Planta. 213: 390-395.

Kovar, D. R., Yang, P., Sale, W. S., Drøbak, B. K., Staiger, C. J. 2001. Chlamydomonas reinhardtii produces a profilin with unusual biochemical properties. J Cell Sci. 114: 4293-4305.

McCurdy, D. W., Kovar, D. R., Staiger, C. J. 2001. Actin and actin-binding proteins in higher plants. Protoplasma. 215: 89-104.

Staiger, C. J. 2000. Signaling to the actin cytoskeleton in plants. Annu Rev Plant Physiol Plant Mol Biol. 51: 257-288.

Hu, S., Brady, S. R., Kovar, D. R., Staiger, C. J., Clark, G. B., Roux, S. J., Muday, G. K. 2000. Technical advance: identification of plant actin-binding proteins by F-actin affinity chromatography. Plant J. 24: 127-137.

Kovar, D. R., Drobak, B. K., Staiger, C. J. 2000. Maize profilin isoforms are functionally distinct. Plant Cell. 12: 583-598.

Kovar, D. R., Staiger, C. J., Weaver, E. A., McCurdy, D. W. 2000. AtFim1 is an actin filament crosslinking protein from Arabidopsis thaliana. Plant J. 24: 625-636.

Schobert, C., Gottschalk, M., Kovar, D. R., Staiger, C. J., Yoo, B-C., Lucas, W. J. 2000. Characterization of Ricinus communis phloem profilin, RcPRO1. Plant Mol Biol. 42: 719-730.

Snowman, B. N., Geitmann, A., Clarke, S.R., Staiger, C.J., Franklin, F.C.H., Emons, A.M.C., Franklin-Tong, V.E. 2000. Signalling and the cytoskeleton of pollen tubes of Papaver rhoeas. Ann Bot. 85: 49-57.

Gibbon, B. C., Kovar, D. R., Staiger, C. J. 1999. Latrunculin B has different effects on pollen germination and tube growth. Plant Cell. 11: 2349-2363.

Clarke, S. R., Staiger, C. J., Gibbon, B. C., Franklin-Tong, V. E. 1998. A potential signaling role for profilin in pollen of Papaver rhoeas. Plant Cell. 10: 967-979.

Gibbon, B. C., Zonia, L. E., Kovar, D. R., Hussey, P. J., Staiger, C. J. 1998. Pollen profilin function depends on interaction with proline-rich motifs. Plant Cell. 10: 981-993.

von Witsch, M., Baluska, F., Staiger, C. J., Volkmann, D. 1998. Profilin is associated with the plasma membrane in microspores and pollen. Eur J Cell Biol. 77: 303-312.

Xu, J. R., Staiger, C. J., Hamer, J. E. 1998. Inactivation of the mitogen-activated protein kinase Mps1 from the rice blast fungus prevents penetration of host cells but allows activation of plant defense responses. Proc Natl Acad Sci U S A. 95: 12713-12718.

Gibbon, B. C., Ren, H., Staiger, C. J. 1997. Characterization of maize (Zea mays) pollen profilin function in vitro and in live cells. Biochem J. 327 ( Pt 3): 909-915.

Ren, H., Gibbon, B. C., Ashworth, S. L., Sherman, D. M., Yuan, M., Staiger, C. J. 1997. Actin Purified from Maize Pollen Functions in Living Plant Cells. Plant Cell. 9: 1445-1457.

Karakesisoglou, I., Schleicher, M., Gibbon, B. C., Staiger, C. J. 1996. Plant profilins rescue the aberrant phenotype of profilin-deficient Dictyostelium cells. Cell Motil Cytoskeleton. 34: 36-47.

Staiger, C. J., Yuan, M., Valenta, R., Shaw, P. J., Warn, R. M., Lloyd, C. W. 1994. Microinjected profilin affects cytoplasmic streaming in plant cells by rapidly depolymerizing actin microfilaments. Curr Biol. 4: 215-219.

Staiger, C., Doonan, J. 1993. Cell division in plants. Curr Opin Cell Biol. 5: 226-231.

Staiger, C. J., Goodbody, K. C., Hussey, P. J., Valenta, R., Drobak, B. K., Lloyd, C. W. 1993. The profilin multigene family of maize: differential expression of three isoforms. Plant J. 4: 631-641.

Staiger, C. J., Cande, W. Z. 1992. Ameiotic, a gene that controls meiotic chromosome and cytoskeletal behavior in maize. Dev Biol. 154: 226-230.

Xu, P., Lloyd, C. W., Staiger, C. J., Drobak, B. K. 1992. Association of Phosphatidylinositol 4-Kinase with the Plant Cytoskeleton. Plant Cell. 4: 941-951.

Staiger, C. J., Cande, W. Z. 1991. Microfilament Distribution in Maize Meiotic Mutants Correlates with Microtubule Organization. Plant Cell. 3: 637-644.

Staiger, C. J., Lloyd, C. W. 1991. The plant cytoskeleton. Curr Opin Cell Biol. 3: 33-42.

Staiger, C. J., Cande, W. Z. 1990. Microtubule distribution in dv, a maize meiotic mutant defective in the prophase to metaphase transition. Dev Biol. 138: 231-242.

Book Section

Li, J., Arieti, R., and Staiger, C. J.  2014.  Actin filament dynamics and their role in plant cell expansion.  In: Plant Cell Shape, Fukuda, H. Springer (ed.).

Staiger, C. J., Hussey, P. J. 2004. Actin and actin-modulating proteins  . In: The Plant Cytoskeleton in Cell Differentiation and Development, P.J. Hussey (ed.), Blackwell Publishing, Sheffield, UK. 32-80.


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