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Nicholas Noinaj Publications


Noinaj N and Buchanan SK, Eds. (2018) Current Opinion in Structural Biology - Membranes (in press). 

Lundquist K, Bakelar J, Noinaj N, Gumbart JC. (2018) C-terminal kink formation is required for lateral gating in BamA. PNAS (in press).

Sikora AE, Wierzbicki IH, Zielke RA, Ryner RF, Korotkov KV, Buchanan SK, and Noinaj N. (2018) Structural and functional insights into the role of BamD and BamE within the b-barrel assembly machinery in Neisseria gonorrhoeae. JBC, 293(4):1106-1119.

O’ Neil P, Richardson LGL, Paila YD, Piszczek G, Chakravarthy S, Noinaj N, Schnell DJ. (2017). The POTRA domains of Toc75 exhibit chaperone-like function to facilitate import into chloroplasts. PNAS, 114(24):E4868-E4876.

Botos I, Noinaj N, and Buchanan SK. (2017). Insertion of proteins and lipopolysaccharide into the bacterial outer membrane. Royal Society Phil. Trans. B, 372(1726).

Noinaj N, Gumbart JC, and Buchanan SK. (2017). The b-barrel assembly machinery in motion. Nature Reviews Microbiology 15(4):197-204.

Bakelar J, Buchanan SK, and Noinaj N. (2016). Structural snapshots of the β-barrel assembly machinery. FEBS 2016 Nov 14. doi: 10.1111/febs.13960.

Celia H, Noinaj N, Zakharov SD, Bordignon E, Botos I, Cramer WA, Lloubes R, and Buchanan SK. (2016). Structural insight into the role of the Ton complex in energy transduction. Nature 538(7623):60-65.

Abeykoon AH, Noinaj N, Choi BE, Wise L, He Y, Chao CC, Wang G, Gucek M, Ching WM, Chock PB, Buchanan SK, Yang DC. (2016). Structural Insights into Substrate Recognition and Catalysis in OmpB by Protein Lysine Methyltransferases from Rickettsia. JBC 291(38):19962-74.

Tinoco AD, Saxena M, Sharma S, Noinaj N, Delgado Y, Quiñones González EP, Conklin SE, Zambrana N, Loza-Rosas SA, Parks TB. (2016). Unusual Synergism of Transferrin and Citrate in the Regulation of Ti(IV) Speciation, Transport, and Toxicity. J Am Chem Soc. 138(17):5659-65.

Bakelar J, Buchanan SK, Noinaj N. (2016). The structure of the β-barrel assembly machinery complex. Science. 351(6269):180-6.

Noinaj N, Mayclin S, Stanley AM, Jao C, Buchanan SK. (2016). From Constructs to Crystals – Towards Structure Determination of β-barrel Outer Membrane Proteins. J. Vis. Exp. (113), e53245, doi:10.3791/53245.

Noinaj N, Rollauer SE, and Buchanan SK. (2015). The b-barrel membrane protein insertase machinery from Gram-negative bacteria. Curr Opin Struct Biol. 2015 Apr;31:35-42.

Buchanan SK and Noinaj N (Eds). (2015). Methods in Molecular Biology: The BAM complex.

Noinaj N, Kuszak AK, and Buchanan SK. (2015). Heat modifiability of outer membrane proteins from Gram-negative bacteria. Methods in Molecular Biology: The BAM complex 1329:51-6.

Kuszak AK, Noinaj N, and Buchanan SK. (2015). Methods to characterize folding and function of BamA crosslink mutants. Methods in Molecular Biology: The BAM complex 1329:137-47.

Noinaj N, Buchanan SK. (2015). Summary and Future Directions. Methods Mol Biol. 1329:279-80.

Rollauer SE, Sooreshjani MA, Noinaj N, Buchanan SK. (2015). Outer membrane protein biogenesis in Gram-negative bacteria. Philos Trans R Soc Lond B Biol Sci. 370(1679).

O'Neil PK, Rollauer SE, Noinaj N, Buchanan SK. (2015). Fitting the Pieces of the β-Barrel Assembly Machinery Complex. Biochemistry 54(41):6303-11.

Cash DR, Noinaj N, Buchanan SK, Cornelissen CN. (2015). Beyond the Crystal Structure: Insight into the Function and Vaccine Potential of TbpA Expressed by Neisseria gonorrhoeae. Infect Immun 83(11):4438-49.

Noinaj N, Kuszak A, Balusek C, Gumbart JC, and Buchanan SK. (2014). Lateral opening and exit pore formation are required for BamA function. Structure, 8:22(7):1055-62.

Noinaj N, Buchanan SK. (2014). FhaC takes a bow to FHA in the two-partner do-si-do. Mol Micro, 92(6):1155-8.

Noinaj N, Buchanan SK. (2014). Structural insights into the transport of small molecules across membranes. Curr Opin Struct Biol., 26;27C:8-15.

Yu X, Strub MP, Barnard TJ, Noinaj N, Piszczek G, Buchanan SK, Taraska JW. (2014). An engineered palette of metal ion quenchable fluorescent proteins. PLoS One. 21;9(4):e95808.

Shen HH, Leyton DL, Belousoff MJ, Noinaj N, Lu J, Holt S, Tan K, Selkrig J, Shiota T, Webb CT, Buchanan SK, Martin L and Lithgow T. (2014). Reconstitution of a nanomachine driving protein assembly into bacterial outer membranes. Nature Communications 5:5078.

Noinaj N, Kuszak AJ, Gumbart JC, Lukacik P, Chang H, Easley NC, Lithgow T, and Buchanan SK. (2013). Structural insight into the biogenesis of b-barrel membrane proteins. Nature, 501(7467):385-90.

Bosserman MA, Downey T, Noinaj N, Buchanan SK, and Rohr J. (2013). Molecular Insight into Substrate Recognition and Catalysis of Baeyer-Villiger Monooxygenase MtmOIV. ACS Chem Biol. 15;8(11):2466-77.

Noinaj N, Cornelissen CN, Buchanan SK. (2013). Structural insight into the lactoferrin receptors from pathogenic Neisseria. J Struct Biol. 2013 184(1):83-92.

Roecker L, Aiyegbo M, Al-Haddad A, Fletcher E, Kc R, Hurst J, Lane T, Larsen R, Noinaj N, Teh SL, Wade SK, Parkin S. (2013). Synthesis and characterisation of [(en)2Co] 3+ complexes coordinated by substituted thiourea ligands. Aust J. Chem, 66(8) 944-951.

Noinaj N, Easley N, Oke M, Mizuno N, Gumbart JC, Boura E, Steere A, Zak O, Aisen P, Tajkhorshid E, Evans RW, Gorringe AR, Mason AB, Steven AC, and Buchanan SK. (2012). Structural basis for iron piracy in pathogenic Neisseria, Nature, 483 (7387):53-8.

White JF, Noinaj N, Shibata Y, Love J, Kloss B, Xu F, Gvozdenovic-Jeremic J, Shah P, Shiloach J, Tate CG, Grisshammer R. (2012). Structure of the agonist-bound neurotensin receptor NTS1. Nature, 490 (7421):508-513.

Noinaj N, Buchanan SK, and Cornelissen CN, (2012). The transferrin–iron import system from pathogenic Neisseria species. Mol Micro, 86 (2):246-257.

Noinaj N, Buchanan SK. (2012). Selenophosphate Synthetase. (Encyclopedia of Metalloproteins).

Noinaj N, Wattanasak R, Lee DY, Wally J, Piszczek G, Chock PB, Stadtman TC, and Buchanan SK. (2012). Structural insights into the catalytic mechanism of E. coli selenophosphate synthetase, J. Bacteriology, 194(2):499-508.

Noinaj N, Song ES, Bhasin S, Alper BJ, Schmidt WK, Hersh LB, and Rodgers DW. (2012). Anion activation site of insulin degrading enzyme, JBC, 287(1):48-57.

Webb C, Selkrig J, Perry A, Noinaj N, Buchanan SK, and Lithgow T. (2012) Dynamic association of BAM complex modules includes surface exposure of the lipoprotein BamC. JMB. 422(4):545-55.

Fairman JW, Dautin N, Wojtowicz, Liu W, Noinaj N, Barnard TJ, Przytycka T, Cherezov V, and Buchanan SK. (2012). Beta-domain structures of Escherichia coli 0157:H7 intimin and Yersinia pseudotuberculosis invasin. Structure, 3;20(7):1233-43.

Barnard T, Gumbart JC, Peterson JH, Noinaj N, Easley NC, Dautin N, Kuszak AJ, Tajkhorshid E, Bernstein HD, and Buchanan SK. (2012). Molecular basis for the activation of a catalytic asparagine residue in a self-cleaving bacterial autotransporter. JMB, 415(1):128-42.

Lukacik P, Barnard TJ, Keller PW, Chaturvedi KS, Seddiki N, Fairman JW, Noinaj N, Kirby TL, Henderson JP, Steven AC, Hinnebusch BJ, and Buchanan SK. (2012) Structural engineering of a phase lysin that targets Gram-negative pathogens. PNAS. 109(25):9857-62.

Noinaj N, Bhasin SK, Song ES, Scoggin KE, Juliano MA, Juliano L, Hersh LB, Rodgers DW. (2011). Identification of the Allosteric Regulatory Site of Insulysin. PLoS One, 6(6): e20864.

Noinaj N, Bosserman MA, Schickli MA, Piszczek G, Kharel MK, Pahari P, Buchanan SK, Rohr J. (2011). The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis. JBC, 286(26):23533-43.

Noinaj N, Fairman JW, Buchanan SK. (2011). The Crystal Structure of BamB Suggests Interactions with BamA and Its Role within the BAM Complex. JMB, 407(2):248-60.

Fairman JW, Noinaj N, Buchanan SK. (2011). The structural biology of b-barrel membrane proteins: a summary of recent reports. Current Opinion in Structural Biology, 21:1–9.

Yamashita, S., Lukacik, P., Barnard, T.J., Noinaj, N. Felek, S., Tsang, T.M., Krukonis, E.S., Hinnebusch, B.J. & Buchanan, S.K. (2011). Structural insights into Ail-mediated virulence in Yersinia pestis, Structure, 19(11):1672-82.

Noinaj N, Guillier M, Barnard T, and Buchanan SK. (2010). TonB-dependent transporters: regulation, structure, and function. Annu Rev Microbiol, 64:43-60.

Tong J, Dolezal P, Selkrig J, Crawford S, Simpson AG, Noinaj N, Buchanan SK, Gabriel K, Lithgow T. (2010). Ancestral and derived protein import pathways in the mitochondrion of Reclinomonas americana. Mol Biol Evol, 28(5):1581-91.

Anwari K, Poggio S, Perry A, Gatsos X, Ramarathinam SH, Williamson NA, Noinaj N, Buchanan S, Gabriel K, Purcell AW, Jacobs-Wagner C, Lithgow T. (2010). A modular BAM complex in the outer membrane of the alpha-proteobacterium Caulobacter crescentus. PLoS One, 5(1):e8619.

Beam MP, Bosserman MA, Noinaj N, Wehenkel M, Rohr J. (2009). Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway. Biochemistry, 48(21):4476-87.


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