Picture of LEUNG

YUK FAI LEUNG

Associate Professor
LILY 2-236
Phone: 765-496-3153

Personal Site: Link

Drug discovery for retinal degeneration

Retinal degeneration is a group of inherited eye diseases including retinitis pigmentosa and age-related macular degeneration that impair our vision. Although much has been learned about the molecular basis of these diseases, they are still incurable. To expedite discovery of new drugs for these diseases, our group at Purdue University studies zebrafish retinal-degeneration models.

We are currently focused in two research directions:

1. Rapid drug discovey for retinal degeneration

2. Gene network for disease and drug action

Please visit our lab website for the most updated information.

Present appointments

2016–present    Affiliate Faculty Member, Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, USA
Aug 2014–present     Associate Professor, Department of Biological Sciences, Purdue University, West Lafayette, IN, USA
October 2013–present    Scientific Advisory Board Member, The Han Institute, West Lafayette, IN, USA                    
May 2013–present    Affiliate Faculty Member, Purdue Center for Drug Discovery, Purdue University, West Lafayette, IN, USA
March 2012–present    Visiting Professor, Shantou University Medical College, Shantou, China
March 2012–present    Scientific Advisor to Post-graduate Research, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China
May 2011–present     Adjunct Assistant Professor of Biochemistry and Molecular Biology, Indiana University School of Medicine—West Lafayette, West Lafayette, IN, USA
2010–present        Affiliate Faculty Member, Purdue Oncological Sciences Center, West Lafayette, IN, USA

Previous appointments

Jan 2008–Aug 2014     Assistant Professor, Department of Biological Sciences, Purdue University, West Lafayette, IN, USA

Education

Ph.D., Chinese University of Hong Kong, Hong Kong, 2002
M.Phil., Hong Kong University of Science and Technology, Hong Kong, 1998
B.Sc., Hong Kong University of Science and Technology, Hong Kong 1996

Awards

2017     Awarded by the first year medical students at the Indiana University School of Medicine—West Lafayette, Class of 2020 for his effective teaching.
2015    Favorite Faculty Award, Purdue University            
2014    J. Alfred and Martha Chiscon Award for Outstanding Undergraduate Teaching, Department of Biological Sciences, Purdue University
2014    Best Lecturer Award, selected by the first year medical students at the Indiana University School of Medicine—Lafayette
2011 International Travel Grant Award, Purdue Research Foundation
2009-2010 Hope for Vision Award
2009-2010, 2010-2011 Showalter Research Trust Award

Other Activities

External reviewer for the following research grants:

2016–present    Health and Medical Research Fund, the Food and Health Bureau, The Government of the Hong Kong Special Administrative Region
2015    Indiana Brain and Spinal Cord Injury Research Fund
2014    The Biotechnology Research Grant, the North Carolina Biotechnology Center, NC, USA
2011    Bank of America Jeffress Research Grant, Thomas F. and Kate Miller Jeffress Memorial Trust, USA
2009    Research Grant, Medical Research Council, United Kingdom
2007    University Research Fund, Research Council, University of Leuven, Belgium

Professional service—Editor:

2017    Co-Editor, Research Topic—“CRISPR Gene Editing in Relation to Eye Diseases and Development”, Frontiers for Cell and Developmental Biology
Oct 2015–present    Associate Editor of Genetic Disorders, a specialty section of Frontiers in Pediatrics and Frontiers in Genetics            
Sep 2015–present    Associate Editor of Systems Biology, a specialty section of Frontiers in Neuroscience, Frontiers in Physiology, Frontiers in Psychiatry, Frontiers in Bioengineering and Biotechnology, Frontiers in Cell and Developmental Biology and Frontiers in Genetics.
Sep 2015–present    Associate Editor of Bioinformatics and Computational Biology, a specialty section of Frontiers in Genetics, Frontiers in Bioengineering and Biotechnology and Frontiers in Plant Science.
2015–present     Review Editor, Frontiers in Bioinformatics and Computational Biology (a specialty section of Frontiers in Bioengineering and Biotechnology, and Genetics)
2012–present     Scientist Advisory Board Member, The National High School Journal of Science
2012–present     Editorial Board Member, PLOS ONE

Ad hoc reviewer for the following journals:

Bioinformatics, BMC Bioinformatics, BMC Developmental Biology, BMC Genomics, Briefings in Bioinformatics, CNS & Neurological Disorders—Drug Targets, Development, Developmental Biology, Expert Opinion for Drug Discovery, FEBS Letters, G3: Genes, Genomes, Genetics, Gene Expression Patterns, Genetics, IEEE Transactions on Image Processing, International Journal of Developmental Neuroscience, Investigative Ophthalmology & Visual Science, Journal of Anatomy, Journal of Neuroscience, Journal of VLSI Signal Processing, Journal of Real Time Imaging, Molecular Biotechnology, Molecular Therapy Nucleic Acids, Molecular Vision, Neurobiology of Disease, Physiological Genomics, PLOS Genetics, PLOS ONE, Protein & Cell, Scientific Reports, Thrombosis Research.

Invited Lectures (2015-2017; total since 2008:58):

11–12 September 2017    “Data, Data Collection and Data sharing” NIH Workshop: Zebrafish and Other Aquatic Models: Description of Extrinsic Environmental Factors for Rigorous Experiments and Reproducible Results, NIH, MD, USA.
24 May 2017    “Discover new drugs for retinal degeneration by zebrafish research”, Eye Hospital, Wenzhou Medical University, Wenzhou, China
22 May 2017    “Discover new drugs for retinal degeneration by zebrafish research”, Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong
20 April 2017    “Discover new drugs for retinal degeneration by zebrafish research”, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA
4 October 2016    Faculty seminar, Neuroscience Research Area, Departmental of Biological Sciences, Purdue University, IN, USA
30 September 2016    Institute for Drug Discovery 3rd Annual Symposium, Purdue University, IN, USA
20 July 2016    "Discover New Drugs for Retinal Degeneration by Zebrafish Research", School of Optometry, Hong Kong Polytechnic University, Hong Kong
19 July 2016    “Use Zebrafish Research to Discover New Drugs for Rod Degenerations", Eye Hospital, Wenzhou Medical University, Wenzhou, China
18 October 2015    "Discover new drugs for rod degeneration with zebrafish research", 2015 Symposium on Biology of Ophthalmology, Hong Kong

Teaching:

2016–Present    Lecturer, MED-X630, Molecules to Cells and Tissues (for medical students), Indiana University School of Medicine—West Lafayette, West Lafayette, IN, USA
2015  BIOL69600 Graduate Seminar Course—Genome Editing: Applications, Opportunities, and Societal Impacts
2009–Present  BIOL 36700 & 36701—Principles of Developmental Biology (Lecture and Lab)
2009–2016  LCME 504—Molecular Cell Biology for Indiana University School of Medicine—West Lafayette

Educational and outreach activities:

2016-07-18 Organizer and Lecturer, "Effective Scientific Communication",  Eye Hospital, Wenzhou Medical University, Wenzhou, China (invited)
2015-10-19–20 Organizer and Lecturer, “Genome Editing Seminar Course”, the Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong, Hong Kong
2015-03-18 Organizer, Zebrafish Research Session for the visit of students from Jefferson high school in Lafayette     
2014-01-09 Organizer and Lecturer, “Workshop on Genome Editing Tools for Medicine”, Joint Shantou International Eye Center of Shantou University and Chinese University of Hong Kong, Shantou, China
2014-01-08 Organizer and Lecturer, “Workshop on Genome Editing Tools for Medicine”, Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong
2013-03-13 “Studying traditional Chinese medicine for good vision with zebrafish”, Ho Yu College, Hong Kong
2012-08-07 Organizer and Lecturer, “Workshop on Immunohistochemistry and in situ hybridization”, Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong
2012-08-06–07 Organizer and Lecturer, “Journal clubs on human genetics and retinal development”, Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong
2012-08-03 Organizer and Lecturer, “Workshop on Immunohistochemistry and in situ hybridization”, Joint Shantou International Eye Center of Shantou University and Chinese University of Hong Kong, Shantou, China
2011-12-14–15 Organizer and Lecturer, Frontiers in human genetics and eye research workshop, Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong
2011-06  Guest Lecturer, OVSC 5580: Genetic Eye Disease, Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong
2010–Present    Facilitator & Lecturer, USA Biology Olympiad (USABO) National Finals, Purdue University, West Lafayette, IN, USA

Professional Faculty Research

(Development and Disease) Drug discovery for retinal degeneration

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