Picture of AGUILAR

R. CLAUDIO AGUILAR

Associate Professor, Assistant Head
HANS 321
Phone: 765-496-3547

My laboratory is focused in the study of protein trafficking and membrane transport in relation to the processes of cell polarity establishment (a feature that is key for animal development and crucial for physiological functions such as synaptic transmission and immune response) and carcinogenic transformation. In order to pursue our research goals we routinely use genetic, biochemistry and cell biology techniques with yeast and mammalian cells. We study protein-protein interactions at molecular level by using bioinformatics, biochemical and genetic tools (like the two-hybrid system) and we investigate the physiological relevance of these interactions by using functional assays, microscopy (of live and fixed cells) and genetic approaches.

Education

Ph.D., University of Buenos Aires, 1996

Awards

  • Sigma Xi Midcareer Research Award, 2017
  • Purdue College of Science Graduate Student Mentoring Award, 2016
  • Louis Stokes Alliance for Minority Participation-IN, Faculty Mentor of the Year, 2015
  • Purdue Research Foundation International Travel Grant, 2014
  • Purdue College of Science Diversity Award, 2014
  • Purdue College of Science Leadership Award, 2013
  • Purdue College of Science Team Award, 2012
  • Purdue Research Foundation International Travel Grant, 2012
  • Purdue University Seeds of Success Award, 2011
  • American Socity for Cell Biology, Minority Affairs Committee, Excellence in Research Award, 2011
  • American Society for Cell Biology: Annual Meeting, Travel Award, 2010
  • American Society for Cell Biology, Minority Affairs Committee, Excellence in Research Award, 2010
  • American Society for Cell Biology: Annual Meeting, Travel Award, 2009
  • American Society for Cell Biology: Annual Meeting, Travel Award, 2007
  • American Society for Cell Biology-Minority Affair Committee: Best Research presentation Award, December, 2007
  • Carl Storm Fellowship, Gordon Research Conference, June 24-30, 2006
  • American Society for Cell Biology: Annual Meeting, Travel Award, 2006
  • European Science Foundation - Research conference on membrane dynamics in endocytosis, Travel Award, 2005
  • American Society for Cell Biology, Travel Award, 2004
  • American Society for Cell Biology, Travel Award, 2002

Other Activities

Professional Organizations:

  • American Society for Cancer Research, 2009-present
  • American Society for Cell Biology, 2001-present

Invited Lectures:

  • "From Basic Cell Biology Research to Novel Therapeutic Approaches: The Case of Lowe Syndrome," the National Institutes of Health, Bethesda, MD. June 2, 2016.
  • "Intracellular Trafficking in Health and Disease," Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN. March 17, 2016.
  • "A Chimeric EGF-Target Bacterial Toxin as Therapeutic Agent Against Bladder Cancer," John P. Donohue Research Symposium, Department of Urology, Indiana University School of Medicine. February 26, 2016.
  • "From Basic Cell Biology Research to Novel Therapeutic Approaches: The Case of Lowe Syndrome," Division of Nephrology, Indiana Univiersity School of Medicine, Indianapolis, IN. January 13, 2016.
  • "Controlling the Notch Signaling Pathway: Saccharomyces cerevisiae to the Rescue," University of Seville, Seville, Spain. March 24, 2015.
  • "Lowe Syndrome: Cellular Phenotypes and Therapeutic Opportunities," Lowe Syndrome Symposium, Lowe Syndrome Trust/Royal Society of London, England. December 12, 2014.
  • "Epsin: A Conserved Multifaceted Protein Linking Endocytosis and Signaling," FIRC Institute of Molecular Oncology, Milan, Italy. June 16, 2014.
  • "Epsin: A Conserved Multifaceted Protein Linking Endocytosis and Signaling," University of Manchester, Manchester, England. June 12, 2014.
  • "Cell Biology of the Lowe Syndrome: Paradigm Shifts," Department of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina. January 9, 2012.
  • "The Syndrome of Lowe as a Ciliopathy: Role of Ocrl1 in Primary Cilia Assembly," American Society for Cell Biology, the 51st Annual Meeting, Denver, CO. December 5, 2011.
  • Department of Biology, Indiana University-Purdue University, Indianapolis, IN, February 18, 2011.
  • "Lowe Syndrom and Signaling: Coordination of Endocytosis and Rac1 Activation by the Inositol 5-phosphatase Ocrl1," Third International Symposium of the Lowe Syndrome Trust, London, England, December 3, 2010.
  • BioConference Live on Cancer Research, June 3, 2010.
  • "Cell Biology of the Lowe Syndrome," Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, May 24, 2010.
  • "Endocytosis and Membrane Remodeling in Cancer and Developmental Diseases," 4th International Symposium on the Membrane Biology of Cancer, Center for Basic and Applied Studies of Biological Membranes, Purdue University, West Lafayette, IN, May 6-8, 2010.
  • "OCRL1 Deficiency Leads to Cell Migration Defects in Low Syndrome Patient Cells," 49th Annual Meeting of The American Society for Cell Biology, San Diego, CA, December 5-9, 2009.
  • 48th Annual Midwest Regional Developmental Biology Meeting, University of Iowa, Iowa City, IA, May 29-31, 2009.

Conferences:

  • 47th Annual Meeting of the American Society for Cell Biology, Washington, DC, December 1-5, 2007.
  • EMBO Federation of European Biochemical Sciences Workshop, Endocytic Systems: Mechanism and Function, Villars-sur-ollon, Switzerland, September 18-23, 2007. Poster presentations: "Novel Role of the Endocytic Adaptor Epsin-2 in Cytokinesis Regulation" by Debarati Mukherjee, Brian G. Coon, and R. Claudio Aguilar from Purdue University; Silvia A. Longhi, J. Michael McCaffrey, and Beverly Wendland from Johns Hopkins University and Lilia A. Retegui from the Departamento de Farmacia y Bioquímica, Instituto de Química y Fisicoquímica Biológicas, Universidad de Buenos Aires.
  • 46th Annual Meeting of the American Society for Cell Biology, San Diego, California, December 9-13, 2006. Poster presentations: "Role of the Endocytic Protein Epsin in Cdc42 Regulation" (co-authored by C. Aguilar and Brian Coon) and "EHD1 regulates LDL Internalization and Cholesterol Homeostasis" (co-authored by C. Aguilar, Brian Coon, Dr. Steve Caplan, UNMC).
  • Gordon Conference on Endocytosis, Andover, New Hampshire, June 24-30, 2006. "Unsuspected Roles of the Endocytic Protein Epsin in Cell Polarity Regulation" (co-authored by C. Aguilar and B. Coon).

Professional Faculty Research

Cell, Molecular, and Developmental Biology

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