Picture of SUTER

DANIEL M. SUTER

Professor
LILY 2-239
Phone: 765-496-1562

Personal Site: Link

Understanding the molecular and cellular mechanisms of cell migration is a major goal in modern biology. Cell movements play a critical role during development, adult life, and in various diseases. Important examples include the growing tip of a nerve cell process, the neuronal growth cone, and the invasive behavior of cancer cells. Our laboratory is currently focusing on the mechanisms of neuronal growth cone motility and guidance. We use two main model systems, Aplysia and zebrafish. Using the large Aplysia neurons in culture, we investigate how the growth cone integrates its sensor, signaling, and motility functions to achieve directional movements towards target cells and establish functional connections. Specifically, we would like to understand how extracellular signals, such as from cell adhesion molecules, are transduced inside the cell to affect the underlying cytoskeleton. These changes ultimately determine speed and direction of growth cone movement. Our current studies aim at the understanding of two different types of chemical signaling, Src tyrosine kinases and reactive oxygen species (ROS) signaling, in addition to mechanical signaling in neurite growth. In the ROS project, we also take advantage of zebrafish embryo to image and manipulate early nervous system development in vivo. We use a combination of quantitative live cell imaging, cell biological, biophysical, molecular and biochemical techniques to investigate the dynamics and function of adhesion, signaling, and cytoskeletal proteins, and to quantify forces involved in cell migration. We hope that our research will not only improve our understanding of the basic cell biology of neuronal growth cones, but also assist in the development of treatments that support axonal regeneration in nervous system diseases and injuries.

Education

Postdoctoral Research in Cellular Neurobiology, Yale University, 1995-2000
Ph.D. in Biochemistry, University of Zurich, 1995

Awards

2017 Graduate Student Mentoring Award, Department of Biological Sciences
2016 J. Alfred and Martha Chiscon Award for Outstanding Undergraduate Teaching
2016 Purdue Research Foundation International Travel Award
2013 Purdue University Seed for Success Award
2012 Purdue Research Foundation International Travel Award
2011 Outstanding Faculty Mentor Award, LSAMP Indiana
2005 Purdue University Seed for Success Award
2003 Purdue Research Foundation International Travel Award

Grants

NSF IOS-1146944 “Nanomechanics of Src signaling in neuronal growth cones”
OVPR Incentive Grant Program "“An integrated AFM platform for cellular dynamics and mechanics”
PRF “NADPH oxidase-derived ROS in axonal growth and guidance”
EVPRP New NIH R01 program “NADPH oxidase-derived reactive oxygen species regulate axonal growth and guidance”

Other Activities

Professional Organizations:

The Biophysical Society 2014-present
The Society for Neuroscience, 2007-present
The American Society for Cell Biology, 1994-present
The Swiss Society for Biochemistry, 1992-present

 

Faculty Presentations, 2011-2016:

"Chemical and mechanical signaling in neuronal growth cones", Department of Biological Sciences, Purdue University, West Lafayette, IN, October 19, 2016.
“ROS signaling regulates neuronal development”, Department of Biology, IUPUI, Indianapolis, IN, September 23, 2016
“The role of traction force in neuronal growth cone advance”. Department of Cell and Developmental Biology, University of Illinois, Urbana-Champaign, IL, March 16, 2016.
“The role of traction force in neuronal growth cone advance”. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, February 17, 2016.
“NADPH oxidase-derived reactive oxygen species in axonal growth and guidance”, Department of Microbiology and Immunology, Montana State University, Bozeman, MT, January 19, 2016.
"Reactive Oxygen Species in Axonal Growth and Guidance", Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland, July 21, 2015.
"Reactive Oxygen Species in Axonal Growth and Guidance", Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, April 29, 2015.
"Src regulation of lamellipodia, filopodia, and substrate-cytoskeletal coupling in neuronal growth cones". Invited talk at virtual Neuroscience  BioConferenceLive, March 19, 2014.
"Src and cortactin regulate growth cone lamellipodia and filopodia", Chicago Cytoskeleton Meeting, Northwestern University, Chicago, IL, March 14, 2014.
"Src Regulation of Lamellipodia, Filopodia, and Substrate-Cytoskeletal Coupling in Neuronal Growth Cones", Department of Chemistry, Purdue University, West Lafayette, September 20, 2013.
"Src Regulation of Lamellipodia, Filopodia, and Substrate-Cytoskeletal Coupling in Neuronal Growth Cones", Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland, June 17, 2013.
"Src Regulation of Lamellipodia, Filopodia, and Substrate-Cytoskeletal Coupling in Neuronal Growth Cones". 2nd Meeting on Emerging Concepts on Neuronal Cytoskeleton. Marbella Resort, Maitencillo, Chile, May 26-30, 2013.
"A novel role for reactive oxygen species in axonal growth and guidance", Department of Biological Sciences, Purdue University, West Lafayette, IN, December 6, 2012.
"A novel role for reactive oxygen species in axonal growth and guidance", Indiana Spinal Cord and Brain Injury Research Forum, Indiana University School of Medicine, Indianapolis, IN, October 3, 2012.
"A Novel Role for ROS in Neuronal Growth Cone Migration", Invited talk at virtual Life Sciences BioConferenceLive, September 12-13, 2012
"The interplay between Src signaling and forces in adhesion-mediated neuronal growth cone migration", Conway Institute of Biomolecular and Biomedical research, University College Dublin, Dublin, Ireland, May 6, 2011.

 

Conferences, 2011-2016:

Organizer of Special Interest Subgroup Meeting “Emerging roles of ROS-related redox signaling in cell biology” at the 56th Annual Meeting of the American Society for Cell Biology, San Francisco, CA, December 3-7, 2016.
Co-Organizer of 622nd WE-Heraeus-Seminar on “Neuronal Mechanics” in Bad Honnef, Germany, August 17-19, 2016.
Gordon Research Conference on Nox Family NADPH Oxidases, Waterville Valley, NH, June 5-10, 2016.
55th Annual Meeting of the American Society for Cell Biology, San Diego, CA, December 12-16, 2015.
54th Annual Meeting of the American Society for Cell Biology, Philadelphia, PA, December 6-10, 2014.
Co-organizer of MBI workshop “Axonal transport and neuronal mechanics”, Mathematical Biosciences Institute (MBI), Ohio State University, November 3-7, 2014.
Virtual Neuroscience  BioConferenceLive, March 19, 2014.
Chicago Cytoskeleton Meeting, Northwestern University, Chicago, IL, March 14, 2014.
53th Annual Meeting of the American Society for Cell Biology, New Orleans, LA, December 14-18, 2013.
2nd Meeting on Emerging Concepts on Neuronal Cytoskeleton. Marbella Resort, Maitencillo, Chile, May 26-30, 2013.
52th Annual Meeting of the American Society for Cell Biology, San Francisco, CA, December 15-19, 2012.
Virtual Life Sciences BioConferenceLive, September 12-13, 2012.

 

Manuscript Reviewer for the following Journals:

ACS Applied Materials and Interfaces
ASN Neuro
Developmental Neurobiology
EMBO Journal
FASEB Journal
FEBS letters
Journal of Biological Chemistry
Journal of Cell Biology
Journal of Cell Science
Journal of Nanoscience and Nanotechnology
Journal of Neurobiology
Journal of Neurochemistry
Journal of Neuroscience
Journal of Neuroscience Methods
Journal of Visualized Experiments
Molecular Biology of the Cell
Molecular and Cellular Neuroscience
Nature Cell Biology
Nature Reviews Neuroscience
Neural Development
Neuron
PLoS ONE
PLoS Computational Biology
PNAS
Scientific Reports

 

Ad hoc Grant Reviewer for the following Agencies:

National Institutes of Health (NIH), SYN and NDPR study sections
National Science Foundation (NSF)
Canada Foundation for Innovation (CFI)
British Council
Vienna Science and Technology Fund
EVPRP Purdue University

Professional Faculty Research

(Cell biology; neurobiology) nervous system development, advanced light microscopy, neuronal growth cone motility and guidance, cell adhesion and migration, cytoskeletal dynamics, signal transduction, biomechanics

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