Our lab integrates aspects of physiology, cell biology, and molecular biology to elucidate the mechanisms by which prolactin (PRL) and growth hormone (GH) regulate locally produced hormones, receptors and growth factors. The main goal of this research is to better understand the complex interactions between the mammary epithelia and stroma. These studies are critical to our understanding of breast cancer, given that circulating levels of GH and PRL can significantly influence mammary tumorigenesis. The study of normal mammary development will provide more specific roles for these hormones and can identify novel potential targets for cancer therapies.
Several hormones, including PRL and GH, are necessary for normal mammary gland development. Two primary components of the mammary gland are epithelial cells, which differentiate to produce milk, and stromal cells consisting primarily of adipocytes. The majority of studies examining PRL and GH action during mammary development have centered on their effects in epithelial cells. Recently, there has been increasing evidence indicating the mammary stroma is a rich source of lipids and growth factors that are critical for epithelial growth. The regulation of these stromal factors by PRL or GH is therefore an important question in mammalian physiology.
Ph.D., Wayne State University, 1996
- Endocrine Society
- Society for Experimental Biology and Medicine
- Society for the Advancement of Chicanos and Native Americans in Science (SACNAS)
- Purdue SACNAS Chapter Advisor
- American Physiology Society
- American Association of Cancer Research
- AACR-Minorities in Cancer Research
- Oncological Sciences Center, Purdue University
- NCI Designated Cancer Center, Purdue University
- Purdue Latino Faculty and Staff Association (Faculty Chair)
- Endocrine Society Conference Research Summaries Book (Top 100 newsworthy abstracts) (2006)
- FASEB MARC Travel Award, (2006)
- Purdue University Latino Staff & Faculty Association (LaFASA) Outstanding Faculty Award (2007)
Invited Lectures, 2006-2008:
- Obesity, leptin and breast cancer, Purdue Cancer Center-Directors Advisory Board Meeting, Purdue University, September 29, 2006.
- Defining the role of leptin and obesity in Breast Cancer, 14th Annual American Cancer Society Great Lakes Cancer Symposium, VanAndel Research Institute, Grand Rapids, Michigan, October 16, 2006.
- The role of obesity in breast cancer, Department of Biomedical Engineering, Purdue University, October 25, 2006.
- Multiphoton imaging to determine the influence of diet and obesity on mammary tumorigenesis Society for Advancement of Chicanos and Native Americans in Science (SACNAS) National Conference, Tampa, Florida, October 26-29, 2006.
- The role of obesity and leptin in breast cancer, Department of Biology Division of Life Sciences, University of Texas at San Antonio, San Antonio, Texas, April 27, 2007.
- Electro-Endocrine Therapy for Aggressive Breast Tumors, Electrostatics Society of America 35thAnnual Meeting, Purdue University, West Lafayette, IN, June 12-14, 2007. Abstract selected for an Invited Talk. An invitation to submit work for publication in Journal of Electrostatics resulted from this oral presentation.
- LSAMP Indiana and Midwest Crossroads AGEP Second Annual Joint Conference, Purdue University, West Lafayette, IN, November 3-4, 2006 . Graduate Student C. Rehrer gave an oral presentation. Camarillo served as judge for student presentations.
- Society for the Advancement of Chicanos and Native Americans National Conference, Tampa, Florida, October 26-29, 2006.
- Cancer Prevention and Control Retreat, Purdue University Oncological Sciences Center, Purdue University, West Lafayette, IN, September 8, 2006.
- Purdue Cancer Center, 8th Annual Scientific Retreat, University Inn, W. Lafayette, IN, September 7, 2006. Two posters presented.
- Annual Endocrine Society Conference, San Diego, California, June 3-6, 2006. 4 poster presentations. One abstract selected for Endocrine Society Conference Research Summaries Book-A listing of 100 newsworthy abstracts. Graduate student C. Perera Awarded Purdue Women in Science Travel Grant to Present Poster. FASEB/MARC Travel Awards provided support for graduate student C. Rehrer and I. Camarillo to present work. I. Camarillo served as Faculty Mentor in Minority Mentoring Session sponsored by Endocrine Society Minority Affairs Committee.
- Peachy Breast Cancer Conference, Indiana University Purdue University, Indianapolis, Indiana, February 11, 2006. Three posters presented.
- Abstract Writing Workshop Society for Advancement of Chicanos and Native Americans in Science (SACNAS) Purdue Chapter sponsored, Purdue University, W. Lafayette, IN, February 21, 2007.
- Graduate School 101 Workshop, Sponsored by Purdue Black Graduate Association LSAMP & AGEP, Purdue University, West Lafayette, IN, February 17, 2007. Served as a panel member in the round table discussion style career development session.
- Abstract Writing Workshop Society for Advancement of Chicanos and Native Americans in Science (SACNAS) National Conference, Tampa, Florida, October 26-29, 2006.
Professional Faculty Research
(Endocrine physiology) Hormonal regulation of mammary gland development; hormone binding protein function.