BIOL 59500PD Pathways in Human Health and Disease
Session Offered:Fall Credit 3
This course is intended for both upper-level undergraduate and graduate students. It will cover major intracellular signaling pathways in eukaryotes and their roles in human disease, with an emphasis on cancer but also touching on other major modern diseases such as COVID-19. We will explore avenues being pursued to target signaling mechanisms for therapeutic benefit. Topics include G protein-coupled receptors, receptor tyrosine kinases, nuclear hormone receptors, protein kinases and phosphatases, mTOR, the Wnt/β-catenin pathway, cell cycle control, DNA damage checkpoint control, regulated proteolysis, and programmed cell death. The course will be taught from current primary literature using a textbook as a background resource. Students will learn how to read and interpret scientific data through regular lectures, extramural seminars, in-class presentations, and take-home assignments.
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