BIOL 53601 Biological & Structural Aspects of Drug Design & Action
Session Offered:Spring Credit
BIOL 23100 or 23000 and CHM 25600 or 26605 or MCMP 20500. Note: A course in Biochemistry such as BCHM 36100, 46200 or CHM 53300, and/or a course in Structural Biology such as BIOL 39500 (Macromolecules), BIOL 44207 or BCHM 46300 is also desired but not required.
This course will provide an overview of the modern day drug discovery pipeline process and an in-depth look at the basic biology, structure, and mechanisms-of actions behind currently marketed therapeutics. The course will start with a historical account of the discovery of natural product drugs such as aspirin and penicillin and will then venture into the modern day era of the drug discovery pipeline with an emphasis on the principles of target selection, assay development, high-throughput screening and structure-based drug design. We will explore different classes of antibiotics, antiviral, and anti-cancer drugs and their targets including small molecule drugs and modern biologics-based drugs.
No textbook required for the course. Instructor notes and additional reading material will be provided or available in the library for reference
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