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Course Descriptions

BIOL 69600 Development & Disease Seminar

Session Offered:

Spring Credit 1.0


None.  Course Restriction:  Permission of Department required.


It is well established that vesicle trafficking and signaling are functionally linked. For example, endocytosis can contribute to the regulation of ligand availability and receptor levels at the cell surface. It is through this mechanism that endocytosis leads to receptor downregulation  and shapes extracellular morphogen gradients. However, endocytosis is also required for signaling activation; it is now recognized that localization of ligand-receptor complexes at endosomal compartments (‘signaling endosomes’) is required for the initiation of specific signaling events. Although the exact mechanism is unknown, endocytosis also plays a crucial role in the activation of the Notch-DSL developmental pathway.

In this class, we will cover a series of topic that illustrate the link between vesicle trafficking & signaling and its potential applications. 

The seminar will be run as a journal club, with students making a 45 min. presentation of a recent paper from the literature.   The paper will be selected by the instructor and provided to the student at least 2 weeks prior to the seminar.



Ed Bartlett



~There is no textbook required for this course~

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