Helpful References for Generating and Using Transgenic and Knock-Out Mice
Books/Manuals
Hogan, B., et al. Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring
Harbor Press. 1994
Wassarman, P.M. and DePamphilis, M.L. Guide to Techniques in Mouse Development.
Methods in Enzymology. Vol. 225. Academic Press. 1993.
Robertson, E.J. Teratocarcinomas and Embryonic Stem Cells; A Practical Approach.
IRL Press at Oxford University. 1987.
Transgenic Review Papers
Brinster, R.L. et al. Factors affecting the efficiency of introducing foreign
DNA into mice by microinjecting eggs. PNAS (USA) 82:4438-4442
Camper, S.A. Research applications of transgenic mice. Biotechniques 5,
638-650.
Landel, C.P. The production of transgenic mice by embryo microinjection. GATA,
8(3): 83-94. 1991.
Gene Targeting: General Reviews
Deng, C. Reexamination of gene targeting frequency as a function of the extent
of homology between the targeting vector and the target locus. MCB. 12:3365-3371.
1992
Galli-Taliadoros, L.A. Gene knockout technology: a methodological overview for
the interested novice. J. Immunol. Meth. 181:1-15
Koller, B.H. Altering genes in animals by gene targeting. Ann. Rev. Immunol. 10:705-730.
1992
Morrow, B. Gene targeting in mammalian cells by homologous recombination. Current
Biology. 4:577-582. 1993.
Ramirez-Solis, R. Gene targeting in Embryonic stem cells. Meth. Enzym. 225:855.
Rossant, J. Genome engineering: the new mouse genetics. Nature Medicine. 1:592-594.
1995.
Gene Targeting/ Techniques and Methodology
Doetshman, T.C. The in vitro development of blastocyst derived embryonic stem
cell lines: formation of visceral yolk sac, blood islands and myocardium. J.
Embryol. Exp. Morphol. 87:27-45.
Skarnes, W.C. The identification of new genes: gene trapping in transgenic mice. Current
Biology. 4:684-689.1993
Mansour, S.L. Introduction of a LacZ reporter gene into the mouse int-2 locus
by homologous recombination. PNAS (USA). 87:8424-8428.
Kuhn, R. Inducible gene targeting in mice. Science. 269:1427-1429.
Orban, P.C. Tissue-and site-specific recombination in transgenic mice. PNAS. 89:6861-6865.
Sauer, B. Manipulation of transgenes by site specific recombination: use of the
Cre recombinase. Methods Enzymol. 225:890-900.
Gu, H. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific
gene targeting. Science. 265:103-106.1994.