LAB PUBLICATIONS

Pin, C.L., Rukstalis, J.M., Johnson, C. and Konieczny, S.F. (2001) The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J. Cell Biol. 155: 519-530.

Mitin, N., Kudla, A.J., Konieczny, S.F. and Taparowsky, E.J. (2001) Differential effects of Ras signaling through NFkB on skeletal myogenesis. Oncogene 20: 1276 - 1286.

Mitin, N., Ramocki, M.B., Konieczny, S.F. and Taparowsky, E.J. (2001) Ras regulation of skeletal muscle differentiation and gene expression. In Methods of Enzymology, Regulation and Effectors of Small GTPases, 333: 232-247, C. Der, Editor, Academic Press.

Pin, C.L., Bonvissuto, A.C. and Konieczny, S.F. (2000) Mist1 expression is a common link among serous exocrine cells exhibiting regulated exocytosis. Anat. Record. 259: 157 -167.

Flick, M.J. and Konieczny, S.F. (2000) The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of BI-spectrin. J Cell Science. 113: 1553-1564.

Peña, T.L., Chen, S.H., Konieczny, S.F. and Rane, S.G. (2000) Ras/MEK/ERK upregulation of the fibroblast KCa channel FIK is a common mechanism for bFGF and TGF-ß suppression of myogenesis. J. Biol. Chem. 275: 13677-13682.

Pin, C.L., Lemercier, C. and Konieczny, S.F. (1999) Cloning of the murine Mist1 gene and assignment to mouse chromosome band 5G2-5G3. Cyogenetics and Cell Genetics. 86: 219-222.

Lemercier, C., To, R. Q., Carrasco, R. A. and Konieczny, S. F. (1998) The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of MyoD. EMBO J. 17: 1412-1422.

Ramocki, M. B., White, M. A., Konieczny, S. F. and Taparowsky, E. J. (1998) A role for RalGDS and a novel Ras effector in the Ras-mediated inhibition of skeletal myogenesis. J. Biol. Chem. 273: 17696-17701.

Pin, C. L., Ludolph, D. C., Cooper, S., Klocke, B. J., Merlie, J. P. and Konieczny, S. F. (1997) Distal regulatory elements control MRF4 gene expression in early and late myogenic cell populations. Dev. Dyn. 208:299-312.

Lemercier, C., To., R. Q., Swanson, B. J., Lyons, G. E. and Konieczny, S. F. (1997) Mist1: A novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern. Dev. Biol. 182: 101-113.

Ramocki, M. B., Johnson, S. E., White, M. A., Ashendel, C. L., Konieczny, S. F. and Taparowsky, E. J. (1997) Signaling through MAP kinase and Rac/Rho does not duplicate the effects of activated Ras on skeletal myogenesis. Mol. Cell Biol. 17:3547-3555.

Kong, Y., Flick, M. J., Kudla, A. J. and Konieczny, S. F. (1997) Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol. Cell Biol. 17: 4750-4760.

Mak, K.-L., Longcor, L. C., Johnson, S. E., Lemercier, C., To, R. and S. F. Konieczny, (1996) Examination of mammalian basic helix-loop-helix transcription factors using a yeast one-hybrid system. DNA and Cell Biology 15:1-8.

Johnson, S. E., Wang, X., Hardy, S., Taparowsky, E. J. and S. F. Konieczny, (1996) Casein kinase II increases the transcriptional activities of MRF4 and MyoD independently of their direct phosphorylation. Mol. Cell. Biol. 16:1604-1613.

Naidu, P. S., Ludolph, D. C., To, R. Q., Hinterberger, T. J. and S. F. Konieczny, (1995) Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis. Mol. Cell Biol. 15:2707-2718.

Ludolph, D. C. and S. F. Konieczny, (1995) Transcription factor families: muscling in on the myogenic program. FASEB J. 9:1595-1604.

Kong, Y., Johnson S. E., Taparowsky, E. J. and S. F. Konieczny, (1995) Ras p21val inhibits myogenesis without altering the DNA binding or transcriptional activities of the muscle regulatory factors. Mol. Cell. Biol. 15:5205-5213.

Smith, T. H., Block, N. E., Rhodes, S. J., Konieczny, S. F. and J. B. Miller, (1993) A unique pattern of expression of the four muscle regulatory factor proteins distinguishes somitic from embryonic, fetal and newborn mouse myogenic cells. Development. 117:1125-1133.

Hardy, S., Kong, Y. and S. F. Konieczny, (1993) FGF inhibits MRF4 activity independent of the phosphorylation status of a conserved threonine residue within the DNA-binding domain. Mol. Cell Biol. 13:5943-5956.

Voytik, S. L., Przyborski, M., Badylak, S. F. and S. F. Konieczny, (1993) Differential expression of muscle regulatory factor genes in normal and denervated adult rat hindlimb muscles. Dev. Dyn. 198:214-224.

Konieczny, S. F., (1992) Functional properties associated with MRF4 and other members of the bHLH muscle regulatory factor family. In Neuromuscular Development and Disease. pp 29-44. A. M. Kelly and H. M. Blau, eds. Raven Press, New York.

Lin, H. and Konieczny, S. F. (1992) Identification of MRF4, myogenin, and E12 oligomer complexes by chemical crosslinking and two-dimensional gel electrophoresis. J. Biol. Chem. 267:4773-4780.

Vaidya, T. B., Rhodes, S. J., Moore, J. L., Sherman, D. A., Konieczny, S. F. and E. J. Taparowsky, (1992) Isolation and structural analysis of the rat MyoD gene. Gene. 116:223-230.

Hinterberger, T. J., Mays, J. L. and S. F. Konieczny, (1992) Structure and myofiber-specific expression of the rat muscle regulatory gene MRF4. Gene. 117:201-207.

Mak, K.-L., To, R. Q., Kong, Y. and S. F. Konieczny, (1992) The MRF4 activation domain is required to induce muscle-specific gene expression. Mol. Cell Biol. 12:4334-4346.

Yutzey, K. E. and S. F. Konieczny, (1992) Different E-box regulatory sequences are functionally distinct when placed within the context of the troponin I enhancer. Nucleic Acids Research. 20:5105-5113.

Lin, H., Yutzey, K. E. and S. F. Konieczny, (1991) Muscle-specific expression of the troponin I gene requires interactions between muscle regulatory and ubiquitous transcription factors. Mol. Cell. Biol. 11:267-280.

Hinterberger, T. J., Sassoon, D. A., Rhodes, S. J. and S. F. Konieczny, (1991) Expression of the muscle regulatory factor MRF4 during somite and skeletal myofiber development. Dev. Biol. 147:144-156.

Yutzey, K. E., Rhodes, S. J. and S. F. Konieczny, (1990) Differential trans-activation associated with the muscle regulatory factors MyoD1, myogenin and MRF4. Mol. Cell. Biol. 10:3934-3944.

Enkemann, S. A., Konieczny, S. F. and E. J. Taparowsky, (1990) Adenovirus 5 E1A represses muscle-specific enhancers and inhibits expression of the myogenic regulatory factor genes, MyoD1 and myogenin. Cell Growth and Differentiation 1:375-382.

Pinney, D. F., Pearson-White, S. H., Konieczny, S. F., Latham, K. E. and C. P. Emerson, Jr., (1989) Evidence for a regulatory gene pathway of myogenic determination and differentiation. pp 67-74, In Cellular and Molecular Biology of Muscle Development, L. H. Kedes and F. E. Stockdale, eds. Alan R. Liss, Inc. New York.

Yutzey, K. E., Kline, R. L and S. F. Konieczny, (1989) An internal regulatory element controls troponin I gene expression. Mol. Cell Biol. 9:1397-1405.

Konieczny, S. F., Drobes, B. L. Menke, S. L. and E. J. Taparowsky, (1989) Inhibition of myogenic differentiation by the H-ras oncogene is associated with the down regulation of the MyoD1 gene. Oncogene 4:473-481.

Vaidya, T., Rhodes, S. J., Taparowsky, E. J. and S. F. Konieczny, (1989) Fibroblast growth factor and transforming growth factor-b repress expression of the myogenic regulatory gene MyoD1. Mol. Cell Biol. 9:3576-3579.

Rhodes, S. J. and S. F. Konieczny, (1989) Identification of MRF4: A new member of the muscle regulatory factor gene family. Genes and Development 3:2050-2061.

Pinney, D. F., Pearson-White, S. H., Konieczny, S. F., Latham, K. E. and C. P. Emerson, Jr., (1988) Myogenic lineage determination: Evidence for a regulatory gene pathway. Cell 53:781-793.

Bucher, E. A., Maisonpierre, P. C., Konieczny, S. F. and C. P. Emerson, Jr., (1988) Expression of the troponin complex genes: transcriptional coactivation during myoblast differentiation and independent control in heart and skeletal muscles. Mol. Cell Biol. 8:4134-4142.

Konieczny, S. F. and C. P. Emerson, Jr., (1987) Complex regulation of the muscle-specific contractile protein (troponin I) gene. Mol. Cell Biol. 7:3065-3075.

Konieczny, S. F., Baldwin, A. S. and C. P. Emerson, Jr., (1986) Myogenic determination and differentiation of 10T1/2 cell lineages: Evidence for a simple genetic regulatory system. pp 21-34, In Molecular Biology of Muscle Development, C. Emerson, D. Fischman, B. Nadal-Ginard and M.A.Q. Siddiqui, eds. Alan R. Liss, Inc. New York.

Konieczny, S. F., and C. P. Emerson, Jr., (1985) Differentiation not determination, regulates muscle gene activation: Transfection of troponin I genes into multipotential and muscle lineages of 10T1/2 cells. Mol. Cell Biol. 5:2423-2432.

Konieczny, S. F., and C. P. Emerson, Jr., (1984) 5-azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: Evidence for regulatory genes controlling determination. Cell 38:791-800.

Konieczny, S. F. and J. R. Coleman, (1983) Analysis of myogenesis by somatic cell hybridization: III. Myogenic competence of hybrids derived from rat L6 myoblasts and mouse primary fibroblasts and myoblasts. Somatic Cell Genetics 9:25-42.

Konieczny, S. F., Lawrence, J. B. and J. R. Coleman, (1983) Analysis of muscle protein expression in polyethylene glycol-induced chicken:rat myoblast heterokaryons. J. Cell Biol. 97:1348-1355.

Konieczny, S. F., McKay, J. and J. R. Coleman, (1982) Isolation and characterization of terminally differentiated chicken and rat skeletal muscle myoblasts. Dev. Biol. 91:11-26.

Lawrence, J. B., Konieczny, S. F., Shaffer, M., Coleman, A. W. and J. R. Coleman, (1982) Analysis of myogenesis by somatic cell hybridization: I. Myogenic competence of homotypic hybrids derived from rat L6 myoblasts. Exp. Cell Res. 142:261-272.

Konieczny, S. F. and J. R. Coleman, (1982) Analysis of the expression of chicken and rat gene products in myoblast x myoblast cell hybrids. Exp. Cell Res. 142:247-260.

Dexter, D. L., Konieczny, S. F., Lawrence, J. B., Shaffer, M., Mitchell, P. and J. R. Coleman, (1981) Induction by butyrate of differentiated properties in cloned murine rhabdomyosarcoma cells. Differentiation 18:115-122.