Structural Biology and Biophysics
Bolin, Jeffrey
Professor of Biological Sciences
(Structural molecular biology; biochemistry) Protein structure and function; X-ray crystallography; metalloenzymes; biodegradation of PCBs and related compounds.
Chen, Jue
Professor of Biological Sciences
(X-ray crystallography and protein chemistry) ABC transporters and membranefusion proteins.
Cramer, William
Henry Koffler Distinguished Professor of Biological Sciences
(Biochemistry; Biophysics) Membrane biochemistry, biophysics; structure-function of membrane proteins.
Eggler, Aimee
Research Assistant Professor
(Molecular Biosciences: Structural Biology and Biophysics; Cancer Biology) Prevention of cancer and other diseases through upregulation of the Nrf2 transcription factor by botanicals and other therapeutic agents
Friedman, Alan
Associate Professor of Biological Sciences
Our research seeks to understand biological structure and its relationship to function by employing a combination of experimentation (structural biology/biophysics) and computation (computational biology/bioinformatics) to answer questions that neither computation nor experiment can answer alone. Questions needing this combined approach include elucidating structural information from challenging systems, where we combine multiple biophysical and biochemical tools to build coherent models.
Golden, Barbara
Pew Scholar & Associate Professor of Biochemistry
Structural Basis for RNA function.
Gribskov, Michael
Professor of Biological Sciences
My lab is interested in the relationship between sequence, structure, function and evolution. This covers a wide variety of specific topics ranging from the evolution of protein families such as protein kinases and prediction of protein kinases substrates, to changes in genomics structure over evolutionary time, and to the prediction and analysis of functional RNA structures.
Jiang, Wen
Associate Professor of Biological Sciences
Cryo-EM
Electron cryo-microscopy (cryo-EM) is an emerging technique that has
seen dramatic progresses and expansion of the field in recent years.
Our research focuses on the technique development and application of
cryo-EM, aiming at higher resolution (3-4 Angstrom), higher throughput
imaging and 3-D reconstruction, and broader applicability for new
target systems and by novice users.
Kuhn, Richard
Professor, Department Head
Gerald and Edna Mann Director of the Bindley Bioscience Center
(Molecular biology and animal virology) Viral gene expression; virus-host interactions; pathogenesis; virus receptors and virus assembly.
Mesecar, Andrew
Walther Professor in Cancer Structural Biology
The fundamental research interests of the Mesecar lab involve elucidating the molecular mechanisms and function of therapeutic enzymes and proteins. We wish to understand at the molecular level how enzymes and proteins recognize their substrates, catalyze their requisite chemical reactions, and trigger signal-transduction cascades. Our ultimate goal is to utilize this fundamental scientific knowledge to develop new therapeutics to treat cancer and infectious diseases.
Post, Carol
Professor
Medicinal Chemistry and Molecular Pharmacology Professor
(Structural biology; computational chemistry and biology) Signal transduction; viral protein structure and function; molecular recognition; enzymatic catalysis; protein dynamics; NMR structure determination.
Rossmann, Michael
Hanley Distinguished Professor of Biological Sciences;
National Academy of Science
(Molecular biology; biophysics) Structure of picornaviruses (rhinoviruses, Mengo virus, coxsackievirus, poliovirus), parvoviruses, alphaviruses and bacteriophages, fX174, f29, T4; molecular evolution.
Sanders, David
Associate Professor of Biological Sciences
(Molecular virology) Entry of retroviruses and other enveloped viruses into cells; mechanism of enzymatic phosphoryl transfer.
Stauffacher, Cynthia
(Biophysics; molecular biology; biochemistry) Macromolecular structure and assembly using X-ray crystallography; membrane associated proteins; enzyme structure and function.
Yernool, Dinesh
Assistant Professor of Biological Sciences
(Biophysics, Biochemistry and Structural Biology) Membrane protein structure and function; transport of ions and molecules across membranes; signal transduction.