Publications

Journal

Hasan, S. S., E. Yamashita, and W. A. Cramer. 2013. Trans-Membrane Signaling and Assembly of the Cytochrome b₆f-Lipidic Charge Transfer Complex. Biochem Biophys Acta (Bioenergetics) Review. in press.

Hasan, S. S., D. Baniulis, J. Stofleth, E. Yamashita, M. Zhalnina, S. D. Zakharov, and W. A. Cramer. 2013. Interactions of Detergents and Lipids with a α-Helical and β-Barrel Integral Membrane proteins, Current Protocols in Protein Science, in press.

Hasan. S. S., J. T. Stofleth, E. Yamashita, and W. A. Cramer. 2013. Lipid-Induced Conformational Changes within the Cytochrome b₆f Complex of Oxygenic Photosynthesis. Biochemistry, 52: 2649-2654.

Hasan, S. S.,  E. Yamashita, D. Baniulis, and W. A. Cramer.  2013.  Quinone-Dependent Proton Transfer Pathways in the Photosynthetic Cytochrome b₆f Complex. Proc. Natl. Acad. Sci., U. S. A., 110: 4297-4302.  PMID: 23440205

Hasan, S. S., E. Yamashita, D. Baniulis, and W. A. Cramer. 2013. An Anhydrous Proton Transfer Pathway in the Cytochrome b₆f Complex, 57^th Biophysical Society Annual Mtg. February 2013, Philadelphia, PA. (abstract)

Baniulis, D., J. T. Stofleth, S. S. Hasan, and W. A. Cramer. 2013. Increased Superoxide Production in the Cytochrome b₆f complex: A function for the enigmatic chlorophyll-A. 57^th Biophysical Society Annual Mtg.  February 2013, Philadelphia, PA. (abstract)

Zakharov, S. D., S. S. Hasan, A. Chauvet, S. Savikhin, and W. A. Cramer. 2013. Electrostatically Constrained Pathway of Intra/Monomer Electron Transfer in the Cytochrome b₆f Complex of Oxygenic Photosynthesis. 57^th Biophysical Society Annual Mtg.  February 2013, Philadelphia, PA. (abstract)

Zakharov, S. D., O. Sharma, M. Zhalnina, E. Yamashita, and W. A. Cramer. 2012. Pathways of Colicin Import: Utilization of BtuB, OmpF Porin, and the TolC Drug Export Protein, Biochemical Soc. Transactions, 40, 1463-1468. PMID:23176499 (in process)

Hasan, S. S. and W. A. Cramer.  2012.  On the Rate Limitations of Electron Transfer in the Photosynthetic Cytochrome b₆f Complex, Physical Chemistry Chemical Physics, 14:13853-13860. PMID: 22890107 (in process) PMCID: PMC3505453 (available 10/28/2013)

Hasan, S. S. and W. A. Cramer.  2012. Lipid Functions in Cytochrome bc Complexes: an Odd Evolutionary Transition in a Membrane Protein Structure, Structure and Dynamics of the Thylakoid Membrane Royal Society Philosophical Transactions B (P. Horton, ed.), 367, 3406-3411. PMID:23148267 (in process) PMCID: PMC3497066 (available 12/19/2013)

Jakes, K., Cramer, W. A. 2012. Border Crossings - Colicins and Transporters. Annual Reviews of Genetics. 46:209-231. PMID: 22934645 (in process)

Cramer, W. A., S. D. Zakharov, E. Yamashita, S. Saif Hasan, H. Zhang, D. Baniulis, M. V. Zhalnina, G. M. Soriano, J. C. Rochet, C. Ryan, and J. Whitelegge. 2011. Membrane Proteins in Four Acts: Function Precedes Structure Determination. For Methods: Membrane Protein Technologies for Structural Biology (ed., R. Stevens), 55, 415-420. Elsevier Press, San Diego. PMID:22079407 PMCID: PMC328554

Nowaczyk, M. M., Wulfhorst, H., Ryan, C. M., Souda, P., Zhang, H., Cramer, W. A., Whitelegge, J. P. 2011. NdhP and NdhQ. Two novel small subunits of the cyanobacterial NDH-1 complex. Biochemistry. 50: 1121-1124. PMID:21244052 PMCID: PMC3040284

Cramer, W. A., Hasan, S. S., Yamashita, E. 2011. The Q Cycle of Cytochrome bc Complexes: a Structure Perspective (a review). Biochim. Biophys. Acta-Bioenergetics. 1807: 788-802 . PMID: 21352799 PMCID: PMC3101715

Hasan, S. S., Yamashita, E., Ryan, C. M., Whitelegge, J. P., Cramer, W. A. 2011. Conservation of Lipid Sites in the Cytochrome bc Complexes. J. Mol. Biol. 414: 145-162. PMID: 21978667 PMCID: PMC3215850.

Ryan, C.M., Souda, P., Bassilian, S., Ujwal, R., Zhang, J., Abramson, J., Ping, P., Durazo, A., Bowie, J.U., Hasan, S.S., Baniulis, D., Cramer, W.A., Kym F. Faull, K.F., and J.P. Whitelegge. 2010. Post-translational Modifications of Integral Membrane Proteins Resolved by Top-down Fourier Transform Mass Spectrometry with Collisionally Activated Dissociation. Mol. Cell. Proteomics. 9: 791-803. PMID: 20093275 PMCID: PMC2871414

Spector, J., S. D. Zakharov, Y. Lill, O. Sharma, W. A. Cramer, and K. Ritchie. 2010. Mobility of the BtuB and OmpF Escherichia Coli Outer Membrane: Implications for dynamic formation of a Translocon Complex. Biophys. J. 99: 3880-3886. PMID: 21156129 PMCID:PMC3000481

Baniulis, D., E. Yamashita, J.P. Whitelegge, A. Zatsman, M.P. Hendrich, and W.A. Cramer. 2009. Structure-function and stability of the cyanobacterial cytochrome b₆f complex from Nostoc sp. PCC 7120. J. Biol. Chem. 284, 9861-9869. PMID: 19189962 PMCID: PMC2665108

Sharma, O., K. A. Datsenko, S. C. Ess, M. V. Zhalnina, B. L. Wanner, and W. A. Cramer. 2009. Genome-wide screens: novel mechanisms in colicin import and cytotoxicity. Molecular Microbiology. 73: 571-585. PMID:19650773 PMCID: PMC3100173

Twigg, A. I., Baniulis, W. A., Cramer, W. A., Hendrich, M. P. 2009. EPR Detection of an O2 Surrogate Bound to Heme c_n of the Cytochrome b₆f Complex. J. Amer. Chem Soc. 131: 12536-12537. PMID: 19681932 PMCID: PMC2806809

Yan, J., N. Dashdorj, D. Baniulis, E. Yamashita, S. Savikhin and W. A. Cramer. 2008. On the Structural Role of the Aromatic Residue Environment of the Chlorophyll a in the Cytochrome b₆f Complex. Biochemistry. 47: 3654-3661. PMID: 18302324

Yamashita, E., Zhalnina, M. V., Zakharov, S. D., Sharma, O., Cramer, W. A. 2008. Crystal structures of the OmpF porin: function in a colicin translocon. Embo J. 27: 2171-2180. PMID: 18636093 PMCID: PMC2516885

Baniulis, D., E. Yamashita, H. Zhang, S. S. Hasan, and W. A. Cramer. 2008. Structure-Function of the Cytochrome b₆f Complex. Photochemistry and Photobiology. 84: 1349-1358. PMID: 19067956

Zakharov, S. D., O. Sharma, O., M. Zhalnina, and W. A. Cramer. 2008. Primary Events in the Colicin Translocon: FRET Analysis of Colicin Unfolding Initiated by Binding to BtuB and OmpF. Biochemistry. 47: 12802-12809.PMID: 18986168

Dashdorj, N., Yamashita, E., Schaibley, J., Cramer, W. A., Savikhin, S. 2007. Ultrafast Optical Pump-Probe Studies of the Cytochrome b₆f Complex in Solution and Crystalline States. J Phys Chem B. 111: 14405-14410. PMID: 18047317

Sharma, O., Cramer, W. A. 2007. Minimum length requirement of the flexible N-terminal translocation subdomain of colicin E3. J Bacteriol. 189: 363-368. PMID: 17085563 PMCID: PMC1797411

Sharma, O., Yamashita, E., Zhalnina, M. V., Zakharov, S. D., Datsenko, K. A., Wanner, B. L., Cramer, W. A. 2007. Structure of the complex of the colicin E2 R-domain and its BtuB receptor. The outer membrane colicin translocon. J Biol Chem. 282: 23163-23170. PMID: 17548346

Yamashita, E., Zhang, H., Cramer, W. A. 2007. Structure of the cytochrome b₆f complex: quinone analogue inhibitors as ligands of heme cn. J Mol Biol. 370: 39-52. PMID: 17498743 PMCID: PMC1993820

Zakharov, S. D., Hulleman, J. D., Dutseva, E. A., Antonenko, Y. N., Rochet, J. C., Cramer, W. A. 2007. Helical alpha α-Synuclein Forms Highly Conductive Ion Channels. Biochemistry. 46: 14369-14379. PMID: 18031063

Adams, K. L., Tsoi, S., Yan, J., Durbin, S. M., Ramdas, A. K., Cramer, W. A., Sturhahn, W., Alp, E. E., Schulz, C. 2006. Fe vibrational spectroscopy of myoglobin and cytochrome f. J. Phys. Chem. B, 110: 530-536. PMID: 16471565

Cherezov, V., Yamashita, E., Liu, W., Zhalnina, M., Cramer, W. A., Caffrey, M. 2006. In meso structure of the cobalamin transporter, BtuB, at 1.95 A resolution. J Mol Biol. 364: 716-734. PMID: 17028020 PMID: PMC1808586

Cramer, W. A., Zhang, H. 2006. Consequences of the structure of the cytochrome b₆f complex for its charge transfer pathways. Biochim Biophys Acta. 1757: 339-345. PMID: 16787635

Cramer, W. A., Zhang, H., Yan, J., Kurisu, G., Smith, J. L. 2006. Transmembrane traffic in the cytochrome b(6)f complex. Annu Rev Biochem. 75: 769-790. PMID: 16756511

Sobko, A. A., Kotova, E. A., Antonenko, Y. N., Zakharov, S. D., Cramer, W. A. 2006. Lipid dependence of the channel properties of a colicin E1-lipid toroidal pore. J Biol Chem. 281: 14408-14416. PMID: 16556601

Sobko, A. A., Kotova, E. A., Zakharov, S. D., Cramer, W. A., Antonenko, Y. N. 2006. Lipid-mediated inactivation of colicin e1 channels by calcium ions. Biochemistry (Mosc). 71: 99-103. PMID: 16457626

Whitelegge, J. P., Laganowsky, A., Nishio, J., Souda, P., Zhang, H., Cramer, W. A. 2006. Sequencing covalent modifications of membrane proteins. J Exp. Bot. 57: 1515-1522. PMID: 16574746

Yan, J., Kurisu, G., Cramer, W. A. 2006. Intraprotein transfer of the quinone analogue inhibitor 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone in the cytochrome b₆f complex. Proc Natl Acad Sci U S A. 103: 69-74. PMID: 16371475 PMCID: PMC1324977

Zakharov, S. D., Zhalnina, M. V., Sharma, O., Cramer, W. A. 2006. The colicin E3 outer membrane translocon: immunity protein release allows interaction of the cytotoxic domain with OmpF porin. Biochemistry. 45: 10199-10207. PMID: 16922495

Zatsman, A. I., Zhang, H., Gunderson, W. A., Cramer, W. A., Hendrich, M. P. 2006. Heme-heme interactions in the cytochrome b₆f complex: EPR spectroscopy and correlation with structure. J. Am. Chem. Soc. 128: 14246-14247. PMID: 17076484 PMCID: PMC2812023

Cramer, W. A., Zhang, H., Yan, J., Kurisu, G. 2005. Binding sites of lipophilic quinone and quinone analogue inhibitors in the cytochrome b₆f complex of oxygenic photosynthesis. Biochem Soc Trans. 33: 921-923.

Dashdorj, N., Zhang, H., Kim, H., Yan, J., Cramer, W. A., Savikhin, S. 2005. The single chlorophyll a molecule in the cytochrome b₆f complex: unusual optical properties protect the complex against singlet oxygen. Biophys J. 88: 4178-4187.

Genji, K., Zakharov, S. D., Zhalnina, M. V., Cramer, W. A. 2005. Molecular mechanism of protein import through receptor complexes: implication of the complex structure of outer membrane receptor and colicin E3. Tanpakushitsu Kakusan Koso. 50: 356-361.

Kim, H., Dashdorj, N., Zhang, H., Yan, J., Cramer, W. A., Savikhin, S. 2005. An anomalous distance dependence of intraprotein chlorophyll-carotenoid triplet energy transfer. Biophys J. 89: L28-30.

Zhang, H., Cramer, W. A. 2005. Problems in obtaining diffraction-quality crystals of hetero-oligomeric integral membrane proteins. J Struct Funct Genomics. 6: 219-223.

Cramer, W. A., Yan, J., Zhang, H., Kurisu, G., Smith, J. L. 2005. Structure of the cytochrome b₆f complex: new prosthetic groups, Q-space, and the hors doeuvres hypothesis for assembly of the complex. Photosynth Res. 85: 133-143. PMID: 15977064

Cramer, W., Bondeau, A., Schaphoff, S., Lucht, W., Smith, B., Sitch, S. 2004. Tropical forests and the global carbon cycle: impacts of atmospheric carbon dioxide, climate change and rate of deforestation. Philos Trans R Soc Lond B Biol Sci. 359: 331-343.

Cramer, W. A. 2004. Ironies in photosynthetic electron transport: a personal perspective. Photosynth Res. 80: 293-305.

Cramer, W. A., Zhang, H., Yan, J., Kurisu, G., Smith, J. L. 2004. Evolution of photosynthesis: time-independent structure of the cytochrome b₆f complex. Biochemistry. 43: 5921-5929.

Kurisu, G., Zhang, H., Smith, J. L., Cramer, W. A. 2004. Structure and function of the cytochrome b₆f complex of oxygenic photosynthesis. Tanpakushitsu Kakusan Koso. 49: 1265-1273.

Misquitta, L. V., Misquitta, Y., Cherezov, V., Slattery, O., Mohan, J. M., Hart, D., Zhalnina, M., Cramer, W. A., Caffrey, M. 2004. Membrane protein crystallization in lipidic mesophases with tailored bilayers. Structure. 12: 2113-2124.

Smith, J. L., Zhang, H., Yan, J., Kurisu, G., Cramer, W. A. 2004. Cytochrome bc complexes: a common core of structure and function surrounded by diversity in the outlying provinces. Curr Opin Struct Biol. 14: 432-439.

Sobko, A. A., Kotova, E. A., Antonenko, Y. N., Zakharov, S. D., Cramer, W. A. 2004. Effect of lipids with different spontaneous curvature on the channel activity of colicin E1: evidence in favor of a toroidal pore. FEBS Lett. 576: 205-210.

Sobko, A. A., Vigasina, M. A., Rokitskaya, T. I., Kotova, E. A., Zakharov, S. D., Cramer, W. A., Antonenko, Y. N. 2004. Chemical and photochemical modification of colicin E1 and gramicidin A in bilayer lipid membranes. J Membr Biol. 199: 51-62.

Yan, J., Cramer, W. A. 2004. Molecular control of a bimodal distribution of quinone-analogue inhibitor binding sites in the cytochrome b(6)f complex. J Mol Biol. 344: 481-493.

Zakharov, S. D., Cramer, W. A. 2004. On the mechanism and pathway of colicin import across the E. Coli outer membrane. Front Biosci. 9: 1311-1317.

Zakharov, S. D., Eroukova, V. Y., Rokitskaya, T. I., Zhalnina, M. V., Sharma, O., Loll, P. J., Zgurskaya, H. I., Antonenko, Y. N., Cramer, W. A. 2004. Colicin occlusion of OmpF and TolC channels: outer membrane translocons for colicin import. Biophys J. 87: 3901-3911.

Zakharov, S. D., Kotova, E. A., Antonenko, Y. N., Cramer, W. A. 2004. On the role of lipid in colicin pore formation. Biochim Biophys Acta. 1666: 239-249.

Zhang, H., Cramer, W. A. 2004. Purification and crystallization of the cytochrome b₆f complex in oxygenic photosynthesis. Methods Mol Biol. 274: 67-78.

Zhang, H., Primak, A., Cape, J., Bowman, M. K., Kramer, D. M., Cramer, W. A. 2004. Characterization of the high-spin heme x in the cytochrome b₆f complex of oxygenic photosynthesis. Biochemistry. 43: 16329-16336.

Yan, J., Cramer, W. A. 2003. Functional insensitivity of the cytochrome b₆f complex to structure changes in the hinge region of the Rieske iron-sulfur protein. J Biol Chem. 278: 20925-20933.

Zhang, H., Kurisu, G., Smith, J. L., Cramer, W. A. 2003. A defined protein-detergent-lipid complex for crystallization of integral membrane proteins: The cytochrome b₆f complex of oxygenic photosynthesis. Proc Natl Acad Sci U S A. 100: 5160-5163.

Kurisu, G., Zakharov, S. D., Zhalnina, M. V., Bano, S., Eroukova, V. Y., Rokitskaya, T. I., Antonenko, Y. N., Wiener, M. C., and Cramer, W. A. 2003. The structure of BtuB with bound colicin E3 R-domain implies a translocon. Nat. Struct. Biol. 10: 948-954. PMID: 14528295

Kurisu, G., Zhang, H., Smith, J. L., Cramer, W. A. 2003. Structure of the cytochrome b₆f complex of oxygenic photosynthesis: tuning the cavity. Science. 302: 1009-1014. PMID: 14526088

Soriano, G. M., Guo, L. W., De Vitry, C., Kallas, T., Cramer, W. A. 2002. Electron transfer from the Rieske iron-sulfur protein (ISP) to cytochrome f in vitro. Is a guided trajectory of the ISP necessary for competent docking?. J Biol Chem. 277: 41865-41871.

Whitelegge, J. P., Zhang, H., Aguilera, R., Taylor, R. M., Cramer, W. A. 2002. Full subunit coverage liquid chromatography electrospray ionization mass spectrometry (LCMS+) of an oligomeric membrane protein: cytochrome b(6)f complex from spinach and the cyanobacterium Mastigocladus laminosus. Mol Cell Proteomics. 1: 816-827.

Zakharov, S. D., Cramer, W. A. 2002. Insertion intermediates of pore-forming colicins in membrane two-dimensional space. Biochimie. 84: 465-475.

Zakharov, S. D., Cramer, W. A. 2002. Colicin crystal structures: pathways and mechanisms for colicin insertion into membranes. Biochim Biophys Acta. 1565: 333-346.

Zakharov, S. D., Rokitskaya, T. I., Shapovalov, V. L., Antonenko, Y. N., Cramer, W. A. 2002. Tuning the membrane surface potential for efficient toxin import. Proc Natl Acad Sci U S A. 99:8654-8659. PMCID: PMC124348.

Soriano, G. M., Cramer, W. A. 2001. Deuterium kinetic isotope effects in the p-side pathway for quinol oxidation by the cytochrome b(6)f complex. Biochemistry. 40: 15109-15116.

Zhang, H., Whitelegge, J. P., Cramer, W. A. 2001. Ferredoxin:NADP+ oxidoreductase is a subunit of the chloroplast cytochrome b₆f complex. J Biol Chem. 276: 38159-38165.