Publications

Journal

Coon, B.G., DiRenzo, D.M., Konieczny, S.F., Aguilar, R.C. 2011. Epsins novel role in cancer cell invasion. Commun Integr Biol. 4: 95-97.

Shi, G., Zhu, L., Sun, Y., Bettencort, R., Damsz, B., Hruban, R. H., Konieczny, S. F. 2009. Loss of the acinar-restricted transcription factor Mist1 accelerates kras-induced pancreatic intraepithelial neoplasia.. Gastorenterology. 136: 1368-1378.

Nozaki, K., Ogawa, M., Williams, J. A., Lafleur, B. J., Ng, V., Drapkin, R. I., Mills, J. C., Konieczny, S. F., Nomura, S., Goldenring, J. R. 2008. A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology. 134: 511-522.

Rovira, M., Delaspre, F., Massumi, M., Serra, S. A., Valverde, M. A., Lloreta, J., Dufresne, M., Payre, B., Konieczny, S. F., Savatier, P., Real, F. X., Skoudy, A. 2008. Murine embryonic stem cell-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation. Gastroenterolgy. 135: 1301-1310.

Jia, D., Sun, Y., Konieczny, S. F. 2008. Mist1 regulates pancreatic acinar cell proliferation through p21^CIP1/WAF1. Gastroenterology. 135: 1687-1697.

Habbe, N., Shi, G., Meguid, R. A., Fendrich, V., Esni, F., Chen, H., Feldmann, G., Stoffers, D. A., Konieczny, S. F., Leach, S. D., Maitra, A. 2008. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci. 105: 18913-18918.

Sharma, R., Lee, J. -S., Bettencourt, R. C., Xiao, C., Konieczny, S. F., Won, Y. -Y. 2008. Effects of the incorporation of a hydrophobic middle block into a PEG-polycation diblock copolymer on the physicochemcial and cell interaction properties of the polymer-DNA complexes. Biomacromolecules. 9: 3294-3307.

Konieczny, S. F., Leach, S. D. 2007. Metaplastic metamorphoses in the mammalian pancreas. Gastroenterology. 133: 2056-2059.

Ramsey, V. G., Doherty, J. M., Chen, C. C., Stappenbeck, T. S., Konieczny, S. F., Mills, J. C. 2007. The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development. 134: 211-222.

Tran, T., Jia, D., Sun, Y., Konieczny, S. F. 2007. The bHLH domain of Mist1 is sufficient to activate gene transcription. Gene Expr. 13: 241-253.

Zhu, L., Shi, G., Schmidt, C. M., Hruban, R. H., Konieczny, S. F. 2007. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol. 171: 263-273. view article

Tuveson, D. A., Zhu, L., Gopinathan, A., Willis, N. A., Kachatrian, L., Grochow, R., Pin, C. L., Mitin, N. Y., Taparowsky, E. J., Gimotty, P. A., Hruban, R. H., Jacks, T., Konieczny, S. F. 2006. Mist1-Kras^G12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Cancer Res. 66: 242-247.

Zhao, Y., Johansson, C., Tran, T., Bettencourt, R., Itahana, Y., Desprez, P. -Y., Konieczny, S. F. 2006. Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required for maintenance of the differentiated state. Mol Endocrinol.

Konieczny, S. F. 2006. Mist1. AfCS-Nature Molecule Pages. doi:10.1038/mp.a003676.01.

Luo, X., Shin, D. M., Wang, X., Konieczny, S. F., Muallem, S. 2005. Aberrant localization of intracellular organelles, Ca²⁺ signaling, and exocytosis in Mist1 null mice. J Biol Chem. 280: 12668-12675.

Mitin, N., Konieczny, S. F., Taparowsky, E. J. 2005. RAS and the RAIN/RasIP1 Effector. Methods Enzymol. 407: 322-335.

Mitin, N. Y., Ramocki, M. B., Zullo, A. J., Der, C. J., Konieczny, S. F., Taparowsky, E. J. 2004. Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. J Biol Chem. 279: 22353-22361.

Zhu, L., Tran, T., Rukstalis, J. M., Sun, P., Damsz, B., Konieczny, S. F. 2004. Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia. Mol Cell Biol. 24: 2673-2681.

Rukstalis, J. M., Kowalik, A., Zhu, L., Lidington, D., Pin, C. L., Konieczny, S. F. 2003. Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1. J Cell Sci. 116: 3315-3325.

Flick, M. J., Konieczny, S. F. 2002. Identification of putative mammalian D-lactate dehydrogenase enzymes. Biochem Biophys Res Commun. 295: 910-916.

Pin, C. L., Konieczny, S. F. 2002. A fast fiber enhancer exists in the muscle regulatory factor 4 gene promoter. Biochem Biophys Res Commun. 299: 7-13.

Wyzykowski, J. C., Winata, T. I., Mitin, N., Taparowsky, E. J., Konieczny, S. F. 2002. Identification of novel MyoD gene targets in proliferating myogenic stem cells. Mol Cell Biol. 22: 6199-6208.

Mitin, N., Kudla, A. J., Konieczny, S. F., Taparowsky, E. J. 2001. Differential effects of Ras signaling through NFκB on skeletal myogenesis. Oncogene. 20: 1276-1286.

Pin, C. L., Rukstalis, J. M., Johnson, C., Konieczny, S. F. 2001. The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J Cell Biol. 155: 519-530.

Mitin, N., Ramocki, M. B., Konieczny, S. F., Taparowsky, E. J. 2001. Ras regulation of skeletal muscle differentiation and gene expression. Methods Enzymol. 333: 232-247.

Flick, M. J., Konieczny, S. F. 2000. The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of βI-spectrin. J Cell Sci. 113 ( Pt 9): 1553-1564.

Peña, T. L., Chen, S. H., Konieczny, S. F., Rane, S. G., . 2000. Ras/MEK/ERK Up-regulation of the fibroblast K_Ca channel FIK is a common mechanism for basic fibroblast growth factor and transforming growth factor-β suppression of myogenesis. J Biol Chem. 275: 13677-13682.

Pin, C. L., Bonvissuto, A. C., Konieczny, S. F. 2000. Mist1 expression is a common link among serous exocrine cells exhibiting regulated exocytosis. Anat Rec. 259: 157-167.

Pin, C. L., Lemercier, C., Konieczny, S. F. 1999. Cloning of the murine Mist1 gene and assignment to mouse chromosome band 5G2-5G3. Cytogenet Cell Genet. 86: 219-222.

Lemercier, C., To, R. Q., Carrasco, R. A., Konieczny, S. F. 1998. The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of MyoD. EMBO J. 17: 1412-1422.

Ramocki, M. B., White, M. A., Konieczny, S. F., Taparowsky, E. J. 1998. A role for RalGDS and a novel Ras effector in the Ras-mediated inhibition of skeletal myogenesis. J Biol Chem. 273: 17696-17701.

Kong, Y., Flick, M. J., Kudla, A. J., Konieczny, S. F. 1997. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol Cell Biol. 17: 4750-4760.

Lemercier, C., To, R. Q., Swanson, B. J., Lyons, G. E., Konieczny, S. F. 1997. Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern. Dev Biol. 182: 101-113.

Pin, C. L., Ludolph, D. C., Cooper, S. T., Klocke, B. J., Merlie, J. P., Konieczny, S. F. 1997. Distal regulatory elements control MRF4 gene expression in early and late myogenic cell populations. Dev Dyn. 208: 299-312.

Ramocki, M. B., Johnson, S. E., White, M. A., Ashendel, C. L., Konieczny, S. F., Taparowsky, E. J. 1997. Signaling through mitogen-activated protein kinase and Rac/Rho does not duplicate the effects of activated Ras on skeletal myogenesis. Mol Cell Biol. 17: 3547-3555.

Johnson, S. E., Wang, X., Hardy, S., Taparowsky, E. J., Konieczny, S. F. 1996. Casein kinase II increases the transcriptional activities of MRF4 and MyoD independently of their direct phosphorylation. Mol Cell Biol. 16: 1604-1613.

Mak, K. -L., Longcor, L. C., Johnson, S. E., Lemercier, C., To, R. Q., Konieczny, S. F. 1996. Examination of mammalian basic helix-loop-helix transcription factors using a yeast one-hybrid system. DNA Cell Biol. 15: 1-8.

Kong, Y., Johnson, S. E., Taparowsky, E. J., Konieczny, S. F. 1995. Ras p21^Val inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix-loop-helix factors. Mol Cell Biol. 15: 5205-5213.

Ludolph, D. C., Konieczny, S. F. 1995. Transcription factor families: muscling in on the myogenic program. FASEB J. 9: 1595-1604.

Naidu, P. S., Ludolph, D. C., To, R. Q., Hinterberger, T. J., Konieczny, S. F. 1995. Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis. Mol Cell Biol. 15: 2707-2718.

Hardy, S., Kong, Y., Konieczny, S. F. 1993. Fibroblast growth factor inhibits MRF4 activity independently of the phosphorylation status of a conserved threonine residue within the DNA-binding domain. Mol Cell Biol. 13: 5943-5956.

Smith, T. H., Block, N. E., Rhodes, S. J., Konieczny, S. F., Miller, J. B. 1993. A unique pattern of expression of the four muscle regulatory factor proteins distinguishes somitic from embryonic, fetal and newborn mouse myogenic cells. Development. 117: 1125-1133.

Voytik, S. L., Przyborski, M., Badylak, S. F., Konieczny, S. F. 1993. Differential expression of muscle regulatory factor genes in normal and denervated adult rat hindlimb muscles. Dev Dyn. 198: 214-224.

Epstein, H. F., Fischman, D. A., Bader, D., Changeux, J. P., Buckhold, K., Ordahl, C. P., Hoffman, E., Kedes, L. H., Konieczny, S. F., Leinwand, L. A. 1992. Myoblast therapy. Science. 257: 738.

Hinterberger, T. J., Mays, J. L., Konieczny, S. F. 1992. Structure and myofiber-specific expression of the rat muscle regulatory gene MRF4. Gene. 117: 201-207.

Lin, H., Konieczny, S. F. 1992. Identification of MRF4, myogenin, and E12 oligomer complexes by chemical cross-linking and two-dimensional gel electrophoresis. J Biol Chem. 267: 4773-4780.

Mak, K. L., To, R. Q., Kong, Y., Konieczny, S. F. 1992. The MRF4 activation domain is required to induce muscle-specific gene expression. Mol Cell Biol. 12: 4334-4346.

Vaidya, T. B., Rhodes, S. J., Moore, J. L., Sherman, D. A., Konieczny, S. F., Taparowsky, E. J. 1992. Isolation and structural analysis of the rat MyoD gene. Gene. 116: 223-230.

Yutzey, K. E., Konieczny, S. F. 1992. Different E-box regulatory sequences are functionally distinct when placed within the context of the troponin I enhancer. Nucleic Acids Res. 20: 5105-5113.

Hinterberger, T. J., Sassoon, D. A., Rhodes, S. J., Konieczny, S. F. 1991. Expression of the muscle regulatory factor MRF4 during somite and skeletal myofiber development. Dev Biol. 147: 144-156.

Lin, H., Yutzey, K. E., Konieczny, S. F. 1991. Muscle-specific expression of the troponin I gene requires interactions between helix-loop-helix muscle regulatory factors and ubiquitous transcription factors. Mol Cell Biol. 11: 267-280.

Enkemann, S. A., Konieczny, S. F., Taparowsky, E. J. 1990. Adenovirus 5 E1A represses muscle-specific enhancers and inhibits expression of the myogenic regulatory factor genes, MyoD1 and myogenin. Cell Growth Differ. 1: 375-382.

Yutzey, K. E., Rhodes, S. J., Konieczny, S. F. 1990. Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4. Mol Cell Biol. 10: 3934-3944.

Konieczny, S. F., Drobes, B. L., Menke, S. L., Taparowsky, E. J. 1989. Inhibition of myogenic differentiation by the H-ras oncogene is associated with the down regulation of the MyoD1 gene. Oncogene. 4: 473-481.

Rhodes, S. J., Konieczny, S. F. 1989. Identification of MRF4: a new member of the muscle regulatory factor gene family. Genes Dev. 3: 2050-2061.

Vaidya, T. B., Rhodes, S. J., Taparowsky, E. J., Konieczny, S. F. 1989. Fibroblast growth factor and transforming growth factor-β repress expression of the myogenic regulatory gene MyoD1. Mol Cell Biol. 9: 3576-3579.

Yutzey, K. E., Kline, R. L., Konieczny, S. F. 1989. An internal regulatory element controls troponin I gene expression. Mol Cell Biol. 9: 1397-1405.

Bucher, E. A., Maisonpierre, P. C., Konieczny, S. F., Emerson, C. P., Jr. 1988. Expression of the troponin complex genes: transcriptional coactivation during myoblast differentiation and independent control in heart and skeletal muscles. Mol Cell Biol. 8: 4134-4142.

Pinney, D. F., Pearson-White, S. H., Konieczny, S. F., Latham, K. E., Emerson, C. P., Jr. 1988. Myogenic lineage determination and differentiation: evidence for a regulatory gene pathway. Cell. 53: 781-793.

Konieczny, S. F., Emerson, C. P., Jr. 1987. Complex regulation of the muscle-specific contractile protein (troponin I) gene. Mol Cell Biol. 7: 3065-3075.

Konieczny, S. F., Emerson, C. P., Jr. 1985. Differentiation, not determination, regulates muscle gene activation: transfection of troponin I genes into multipotential and muscle lineages of 10T1/2 cells. Mol Cell Biol. 5: 2423-2432.

Konieczny, S. F., Emerson, C. P., Jr. 1984. 5-Azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: evidence for regulatory genes controlling determination. Cell. 38: 791-800.

Konieczny, S. F., Coleman, J. R. 1983. Analysis of myogenesis by somatic cell hybridization: III. Myogenic competence of hybrids derived from rat L6 myoblasts and mouse primary fibroblasts and myoblasts. Somatic Cell Genet. 9: 25-42.

Konieczny, S. F., Lawrence, J. B., Coleman, J. R. 1983. Analysis of muscle protein expression in polyethylene glycol-induced chicken: rat myoblast heterokaryons. J Cell Biol. 97: 1348-1355.

Konieczny, S. F., Coleman, J. R. 1982. Analysis of the expression of chicken and rat gene products in myoblast x myoblast cell hybrids. Exp Cell Res. 142: 247-260.

Konieczny, S. F., McKay, J., Coleman, J. R. 1982. Isolation and characterization of terminally differentiated chicken and rat skeletal muscle myoblasts. Dev Biol. 91: 11-26.

Lawrence, J. B., Konieczny, S. F., Shaffer, M., Coleman, A. W., Coleman, J. R. 1982. Analysis of myogenesis by somatic cell hybridization: I. Myogenic competence of homotypic hybrids derived from rat L6 myoblasts. Exp Cell Res. 142: 261-272.

Dexter, D. L., Konieczny, S. F., Lawrence, J. B., Shaffer, M., Mitchell, P., Coleman, J. R. 1981. Induction by butyrate of differentiated properties in cloned murine rhabdomyosarcoma cells. Differentiation. 18: 115-122.